Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Pascale Plas"'
Autor:
Pascale Plas, Lorenzo Limana, Denis Carré, Amath Thiongane, Olivier Raguin, Rosalba Mansi, Florence Meyer-Losic, Stéphane Lezmi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1085 (2022)
Limited experiments have compared the treatment effects of repetitive cycles of radiolabelled somatostatin (SST) analogues. In vitro and in vivo experiments were conducted in an AR42J cancer cell model, comparing the antagonist [177Lu]Lu-satoreotide
Externí odkaz:
https://doaj.org/article/9b5dea50747d4fda984a66cc498c85c7
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1265 (2021)
Treatment of neuroendocrine tumours with the radiolabelled somatostatin receptor subtype 2 (SST2) peptide agonist [177Lu]Lu-DOTA-TATE is effective and well-established. Recent studies suggest improved therapeutic efficacy using the SST2 peptide antag
Externí odkaz:
https://doaj.org/article/5a186935420d48688f6b9b644c5edc80
Autor:
Olivier Raguin, Marcel Krüger, Peggy Provent, Funda Cay, Elodie Marie dit chatel, Marie Lux, Stéphane Lezmi, Florence Meyer-Losic, Pascale Plas, Ben Pais, Cyril Berthet
Publikováno v:
Cancer Research. 83:5044-5044
Only a limited number of studies have compared the therapeutic effects of repetitive cycles of radiolabeled somatostatin (SST) analogues or assessed potential synergy of these analogues with chemotherapy agents. Hence, a comparison was conducted in a
Tasquinimod inhibits prostate cancer growth in bone through alterations in the bone microenvironment
Autor:
Malin Hagberg Thulin, Lisa U. Magnusson, Pascale Plas, Karin Welén, Anders Olsson, Jan-Erik Damber
Publikováno v:
The Prostate. 76:383-393
BACKGROUND Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that inhibits occurrence of experimental metastasis and delays disease progression of castration resistant prostate cancer in humans. Its mechanism of action is no
Autor:
Anette Sundstedt, Marie Törngren, Valérie Pierron, David Liberg, Jessica Nakhle, Anne-Laure Bauchet, Adnan Deronic, Pascale Plas, Luce Bruetschy, Tomas Leanderson, Fabien Schmidlin, Anders Olsson
Publikováno v:
Journal for Immunotherapy of Cancer
Background Tasquinimod (a quinoline-3-carboxyamide) is a small molecule immunotherapy with demonstrated effects on the tumor microenvironment (TME) involving immunomodulation, anti-angiogenesis and inhibition of metastasis. A target molecule of tasqu
Autor:
Valerie Brault, Sonia Bernetiere, José Camara, Pascale Plas, Pierre Roubert, Lydie Poitout, Carole Sackur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4464-4470
A novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood-brain barrier after intravenous do
Tasquinimod inhibits prostate cancer growth in bone through alterations in the bone microenvironment
Autor:
Lisa U, Magnusson, Malin, Hagberg Thulin, Pascale, Plas, Anders, Olsson, Jan-Erik, Damber, Karin, Welén
Publikováno v:
The Prostate. 76(4)
Tasquinimod (ABR-215050) is an orally active quinoline-3-carboxamide analog that inhibits occurrence of experimental metastasis and delays disease progression of castration resistant prostate cancer in humans. Its mechanism of action is not fully elu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3555-3559
Novel 3-thio-1,2,4-triazoles have been obtained via a solution-phase parallel synthesis strategy, affording potent non-peptidic human somatostatin receptor subtypes 2 and 5 agonists.
Autor:
Pierre Roubert, Christophe Thurieau, Dennis Bigg, Lydie Poitout, Christophe Moinet, Jacques Pommier, Pascale Plas, Marie-Odile Contour-Galcera, Lannoy Jacques
Publikováno v:
Journal of Medicinal Chemistry. 44:2990-3000
Using a solution-phase parallel synthesis strategy, a series of non-peptide somatostatin analogues were prepared, and their binding affinities to the five human somatostatin receptor subtypes (sst(1-5)) were determined. Imidazolyl derivatives 2 were
Autor:
Laurence Abadie, Pierre Roubert, Marina Charbit, Isabelle Blazy, Michèle Dechaux, Pascale Plas, Pierre Etienne Chabrier
Publikováno v:
Pediatric Nephrology. 10:185-189
Endothelin-1 (Et1), like angiotensin II, is implicated in postnatal maturation and development. The present study was designed to identify Et1 receptors and subtype Et1 receptors present in rat kidney between 1 and 30 days of postnatal life. On day 1