Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Pascale Mauvais"'
Autor:
Michel Murer, Michel Klich, Fabienne Chatreaux, Anne Ferreira, Véronique Loyau, Alain Bonnefoy, Laurent Schio, Pascale Mauvais
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1461-1464
A novel series of novobiocin analogues has been synthesised by removing the lipophilic aryl chain in novobiocin and introducing an amino substituent. The structural modifications have been dictated by the control of lipophilicity and the dissociation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dac3ebec8474199aeaee8eb6e7247d1
https://doi.org/10.1016/s0960-894x(01)00257-8
https://doi.org/10.1016/s0960-894x(01)00257-8
Publikováno v:
Douthwaite, S, Hansen, L H & Mauvais, P 2000, ' Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA ', Molecular Microbiology, vol. 36, no. 1, pp. 183-193 . https://doi.org/10.1046/j.1365-2958.2000.01841.x
Udgivelsesdato: 2000-Apr The macrolide antibiotic erythromycin and its 6-O-methyl derivative (clarithromycin) bind to bacterial ribosomes primarily through interactions with nucleotides in domains II and V of 23S rRNA. The domain II interaction occur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ebd8306578490a44a01e430402ce68
https://doi.org/10.1046/j.1365-2958.2000.01841.x
https://doi.org/10.1046/j.1365-2958.2000.01841.x
Autor:
Patrick Laurin, Pascale Mauvais, Alain Bonnefoy, Michel Klich, Patrice Lassaigne, Claudine Dupuis-Hamelin, Branislav Musicki, Christophe Peixoto
Publikováno v:
Tetrahedron Letters. 41:1741-1745
The design, synthesis and in vitro biological evaluation of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide analogues of coumarin inhibitors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzooxathiin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3061360d1ba9cf6259ea4012083b9848
https://doi.org/10.1016/s0040-4039(00)00044-7
https://doi.org/10.1016/s0040-4039(00)00044-7
Autor:
Periers Anne-Marie, Alain Bonnefoy, Didier Ferroud, Michel Klich, Patrice Lassaigne, Pascale Mauvais, Branislav Musicki, Jean-Luc Haesslein, Patrick Laurin, Claudine Dupuis-Hamelin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:161-165
The synthesis and biological profile in vitro of a series of coumarin inhibitors of gyrase B bearing a N-propargyloxycarbamate at C-3' of noviose is presented. Replacement of the 5-methylpyrrole-2-carboxylate of coumarin drugs with an N-propargyloxyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7759aba47e7200be6016886f62b04427
https://doi.org/10.1016/s0960-894x(99)00654-x
https://doi.org/10.1016/s0960-894x(99)00654-x
Autor:
Nathalie Evrard-Todeschi, Pascale Mauvais, Jean-Pierre Girault, Laurent Verdier, Gildas Bertho, Josyane Gharbi-Benarous
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :2363-2371
This paper characterises low-affinity antibiotic binding interactions by the T2 (CPMG) method. Three different compounds, a ketolide ‘telithromycin’ (HMR 3647), a macrolide ‘roxithromycin’ and a lincosamide ‘clindamycin’ belonging to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::831b9c0d0f2b5d927c9e6e42d09b9f0f
https://doi.org/10.1039/b007666j
https://doi.org/10.1039/b007666j
Autor:
Michel Klich, Claudine Dupuis-Hamelin, Jeannine Collard, Patrice Lassaigne, Pascale Mauvais, Didier Ferroud, Alain Bonnefoy, Branislav Musicki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2881-2886
A series of novobiocin-like coumarincarboxylic acids has been prepared bearing the L-rhamnosyl moiety as the sugar portion of the molecule. The similar DNA gyrase inhibitory activity of the novel class of coumarins to that of novobiocin demonstrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6d231e9b554c2dc069f0da68c586cf
https://doi.org/10.1016/s0960-894x(99)00493-x
https://doi.org/10.1016/s0960-894x(99)00493-x
Autor:
Alain Bonnefoy, Pascale Mauvais, Laurent Schio, Claudine Dupuis-Hamelin, Patrick Laurin, Michael Klich, Didier Ferroud, Patrice Lassaigne, Branislav Musicki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2875-2880
Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8317ecf0f78a79b58fec6c034c268203
https://doi.org/10.1016/s0960-894x(99)00492-8
https://doi.org/10.1016/s0960-894x(99)00492-8
Publikováno v:
Molecular Microbiology. 31:633-639
Ketolides represent a new generation of macrolide antibiotics. In order to identify the ketolide-binding site on the ribosome, a library of Escherichia coli clones, transformed with a plasmid carrying randomly mutagenized rRNA operon, was screened fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f98d2a61a097cdf943b041f37ac6345
https://doi.org/10.1046/j.1365-2958.1999.01203.x
https://doi.org/10.1046/j.1365-2958.1999.01203.x
Autor:
Pascale Mauvais, Didier Ferroud, Alain Bonnefoy, Patrice Lassaigne, Michel Klich, Branislav Musicki, Claudine Dupuis-Hamelin, Patrick Laurin
Publikováno v:
ChemInform. 30
The design, synthesis, and in vitro biological activity of a series of novel coumarin inhibitors of gyrase B is presented. Replacement of the 3-acylamino residue (3-NHCOR) of coumarin drugs with reversed isosteres C(=O)R, C(=N-OR)R', COOR, CONHR and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a749e5802e55302ecc6f9d527999646b
https://doi.org/10.1002/chin.199944288
https://doi.org/10.1002/chin.199944288
Autor:
Michel Klich, Pascale Mauvais, Alain Bonnefoy, Branislav Musicki, Didier Ferroud, Claudine Dupuis-Hamelin, Patrice Lassaigne, Jeannine Collard
Publikováno v:
ChemInform. 31
A series of novobiocin-like coumarincarboxylic acids has been prepared bearing the L-rhamnosyl moiety as the sugar portion of the molecule. The similar DNA gyrase inhibitory activity of the novel class of coumarins to that of novobiocin demonstrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e71bbc622902f7dadd832b46af3fdf4b
https://doi.org/10.1002/chin.200006212
https://doi.org/10.1002/chin.200006212