Differential Accumulation and Activation of Monocyte and Dendritic Cell Subsets in Inflamed Synovial Fluid Discriminates Between Juvenile Idiopathic Arthritis and Septic Arthritis

Autor: Maïlys Cren, Nadège Nziza, Aurélia Carbasse, Perrine Mahe, Emilie Dufourcq-Lopez, Marion Delpont, Hugues Chevassus, Mirna Khalil, Thibault Mura, Isabelle Duroux-Richard, Florence Apparailly, Eric Jeziorski, Pascale Louis-Plence

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Despite their distinct etiology, several lines of evidence suggest that innate immunity plays a pivotal role in both juvenile idiopathic arthritis (JIA) and septic arthritis (SA) pathophysiology. Indeed, monocytes and dendritic cells (DC) are involve

Externí odkaz: https://doaj.org/article/f962719554754742b4de90921afe6e56

Systemic LPS Translocation Activates Cross-Presenting Dendritic Cells but Is Dispensable for the Breakdown of CD8+ T Cell Peripheral Tolerance in Irradiated Mice.

Autor: Gabriel Espinosa-Carrasco, Marine Villard, Cecile Le Saout, Pascale Louis-Plence, Rita Vicente, Javier Hernandez

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0130041 (2015)

Lymphodepletion is currently used to enhance the efficacy of cytotoxic T lymphocyte adoptive transfer immunotherapy against cancer. This beneficial effect of conditioning regimens is due, at least in part, to promoting the breakdown of peripheral CD8

Externí odkaz: https://doaj.org/article/19a027b7957b48b0b92a397acd370340

Arthritis sensory and motor scale: predicting functional deficits from the clinical score in collagen-induced arthritis

Autor: Florence Apparailly, Maïlys Cren, Anne-Laure Mausset-Bonnefont, Pascale Louis-Plence, Julie Quentin, Christian Jorgensen, Rita Vicente

Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-12 (2019)
Arthritis Research and Therapy
Arthritis Research and Therapy, BioMed Central, 2019, 21 (264), ⟨10.1186/s13075-019-2047-z⟩
Arthritis Research & Therapy

Background In the collagen-induced arthritis (CIA) mouse model, inflammation readouts are usually quantified using operator-dependent clinical scoring systems, and no systematic relationship with functional deficits has been detected. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9df09937dcc93ec523ab7fd1b5174811
https://doaj.org/article/7e6282c152e643c895cebbeec9417994

Nonclassical CD4+CD49b+ Regulatory T Cells as a Better Alternative to Conventional CD4+CD25+ T Cells To Dampen Arthritis Severity

Autor: Paul Chuchana, Anne-Laure Mausset-Bonnefont, Rita Vicente, Delphine Martire, Pascale Louis-Plence, Christian Jorgensen, Julie Quentin, Maïlys Cren

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015, 196 (1), pp.298-309. ⟨10.4049/jimmunol.1501069⟩

supplementary data : https://www.jimmunol.org/content/suppl/2015/11/19/jimmunol.1501069.DCSupplemental; International audience; Promising immunotherapeutic strategies are emerging to restore tolerance in autoimmune diseases by triggering an increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a59aaa6619467184b86d107232004d
https://doi.org/10.4049/jimmunol.1501069

07.16 Nlrp1 mutations cause autoinflammatory diseases in human: implication of the nlrp1 inflammasome?

Autor: Florence Apparailly, Sylvie Grandemange, Elodie Sanchez, John C. Reed, David Geneviève, Pascale Louis-Plence, Yasamine El Ahmadi, Cécile Rittore, Isabelle Touitou

Publikováno v: Genes and environment.

Background Inflammation is a vital and complex process in response to diverse tissue damaging stimuli such as trauma, injury and pathogen. NLRP1, NLRP3 and NLRC4 belonging to the intracellular proteins Nod like receptor family, are capable of sensing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b52707d2b5e9b59e4a3b51ff362720fc
https://doi.org/10.1136/annrheumdis-2016-211054.16