Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Pascale Legault"'
High-yield production of human Dicer by transfection of human HEK293-EBNA1 cells grown in suspension
Autor:
Jonathan Bouvette, Dursun Nizam Korkut, Aurélien Fouillen, Soumiya Amellah, Antonio Nanci, Yves Durocher, James G. Omichinski, Pascale Legault
Publikováno v:
BMC Biotechnology, Vol 18, Iss 1, Pp 1-13 (2018)
Abstract Background Dicer is a 219-kDa protein that plays key roles in gene regulation, particularly as the ribonuclease III enzyme responsible for cleaving precursor miRNA substrates. Its enzymatic activity is highly regulated by protein factors, an
Externí odkaz:
https://doaj.org/article/a05d2271830643e2a4a1d9e1303d4e19
Publikováno v:
Nucleic Acids Research
The divide-and-conquer strategy is commonly used for protein structure determination, but its applications to high-resolution structure determination of RNAs have been limited. Here, we introduce an integrative approach based on the divide-and-conque
Publikováno v:
Ribozymes. :463-485
Autor:
Eric Bareke, Ze'ev Melamed, Laurie Destroimaisons, Lorne Zinman, Geneviève Di Tomasso, Elizabeth M. H. Tank, Martine Tétreault, Pascale Legault, Anaïs Aulas, Jade-Emmanuelle Deshaies, Sami J. Barmada, Shangxi Xiao, J. Alex Parker, Janice Robertson, Hana Fakim, Christine Vande Velde, Hadjara Sidibé, Paul M. McKeever, Nicolás B. Gómez, Yousra Khalfallah
Publikováno v:
Brain
TDP-43 nuclear depletion and concurrent cytoplasmic accumulation in vulnerable neurons is a hallmark feature of progressive neurodegenerative proteinopathies such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cellular stre
Autor:
Clélia Florence, Alix Salvail-Lacoste, Guillaume Fortin, Willemieke M. Kouwenhoven, Louis-Eric Trudeau, Benoît Delignat-Lavaud, Christian Rosenmund, Anna-Maija Penttinen, Pascale Legault, Raj Awatramani, Thorsten Trimbuch, Milagros Pereira Luppi, Marie-Josée Bourque, Jean-François Poulin
Publikováno v:
J Neurosci
A subset of adult ventral tegmental area dopamine (DA) neurons expresses vesicular glutamate transporter 2 (VGluT2) and releases glutamate as a second neurotransmitter in the striatum, while only few adult substantia nigra DA neurons have this capaci
Autor:
Yousra Khalfallah, Janice Robertson, Lorne Zinman, Nicolás B. Gómez, G. Di Tomasso, Elizabeth M. H. Tank, Laurie Destroismaisons, Shangxi Xiao, Paul M. McKeever, C. Vande Velde, Z. Melamed, Sami J. Barmada, Martine Tétreault, Anaïs Aulas, Pascale Legault, Eric Bareke, Hadjara Sidibé, J. A. Parker, Jade-Emmanuelle Deshaies
TDP-43 nuclear depletion and concurrent cytoplasmic accumulation in vulnerable neurons is a hallmark feature of progressive neurodegenerative proteinopathies such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cellular stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d06a91b9e2f40672fe5ec256cb9016e6
https://doi.org/10.1101/2020.09.15.298455
https://doi.org/10.1101/2020.09.15.298455
Autor:
Pascale Legault, Pierre Dagenais
Publikováno v:
Methods in Molecular Biology ISBN: 9781071607152
In vitro selection is an established approach to create artificial ribozymes with defined activities or to modify the properties of naturally occurring ribozymes. For the Varkud satellite ribozyme of Neurospora, an in vitro selection protocol based o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12b05c71367e1e07f4fc8457045f23b5
https://doi.org/10.1007/978-1-0716-0716-9_5
https://doi.org/10.1007/978-1-0716-0716-9_5
Akademický článek
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Autor:
Lauriane Lecoq, Pascale Legault, Philippe R. Chabot, James G. Omichinski, Geneviève Arseneault, Normand Cyr, Luca Raiola
Publikováno v:
Nucleic Acids Research
p65 is a member of the NF-κB family of transcriptional regulatory proteins that functions as the activating component of the p65–p50 heterodimer. Through its acidic transactivation domain (TAD), p65 has the capacity to form interactions with sever
Publikováno v:
Nucleic Acids Research
Investigating the dynamics of structural elements in functional RNAs is important to better understand their mechanism and for engineering RNAs with novel functions. Previously, we performed rational engineering studies with the Varkud satellite (VS)