Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pascale Klopp"'
Autor:
Céline Pomié, Vincent Blasco-Baque, Pascale Klopp, Simon Nicolas, Aurélie Waget, Pascale Loubières, Vincent Azalbert, Anthony Puel, Frédéric Lopez, Cédric Dray, Philippe Valet, Benjamin Lelouvier, Florence Servant, Michael Courtney, Jacques Amar, Rémy Burcelin, Lucile Garidou
Publikováno v:
Molecular Metabolism, Vol 5, Iss 6, Pp 392-403 (2016)
Objective: To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota crosstalk. Methods: We triggered the immune system with microbial extracts specifically from the inte
Externí odkaz:
https://doaj.org/article/e5665fbf701e453c8a5af6d69022b99a
Autor:
Simon Nicolas, Vincent Blasco‐Baque, Audren Fournel, Jerome Gilleron, Pascale Klopp, Aurelie Waget, Franck Ceppo, Alysson Marlin, Roshan Padmanabhan, Jason S Iacovoni, François Tercé, Patrice D Cani, Jean‐François Tanti, Remy Burcelin, Claude Knauf, Mireille Cormont, Matteo Serino
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 3, Pp n/a-n/a (2017)
Abstract Gut microbiota dysbiosis has been implicated in a variety of systemic disorders, notably metabolic diseases including obesity and impaired liver function, but the underlying mechanisms are uncertain. To investigate this question, we transfer
Externí odkaz:
https://doaj.org/article/b955560a33e845d1b23e5d096d6e2b27
Autor:
Thi-Mai Anh Dao, Aurélie Waget, Pascale Klopp, Matteo Serino, Christelle Vachoux, Laurent Pechere, Daniel J Drucker, Serge Champion, Sylvain Barthélemy, Yves Barra, Rémy Burcelin, Eric Sérée
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20700 (2011)
Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV remain unclear. We used a formulation that increases oral bioavailability to assess the mec
Externí odkaz:
https://doaj.org/article/8b96eb10e8834befa95800ee2058fc4c
Autor:
Estelle Grasset, Rémy Burcelin, Florence Servant, Jeffrey E. Christensen, Vincent Blasco-Baque, Anthony Puel, Pascale Klopp, Benjamin Lelouvier, Julie Charpentier, François Tercé
Publikováno v:
Acta diabetologica. 59(2)
The gut–brain–beta cell glucagon-like peptide-1 (GLP-1)-dependent axis and the clock genes both control insulin secretion. Evidence shows that a keystone of this molecular interaction could be the gut microbiota. We analyzed in mice the circadian
Autor:
Aurélie Waget, Pascale Klopp, Rémy Burcelin, Shin J. Lee, Céline Cruciani-Guglielmacci, Estelle Grasset, Christophe Magnan, Julie Charpentier
Publikováno v:
AJP-Gastrointestinal and Liver Physiology
AJP-Gastrointestinal and Liver Physiology, American Physiological Society, 2018, 315 (5), pp.G671-G684. ⟨10.1152/ajpgi.00348.2017⟩
AJP-Gastrointestinal and Liver Physiology, 2018, 315 (5), pp.G671-G684. ⟨10.1152/ajpgi.00348.2017⟩
AJP-Gastrointestinal and Liver Physiology, American Physiological Society, 2018, 315 (5), pp.G671-G684. ⟨10.1152/ajpgi.00348.2017⟩
AJP-Gastrointestinal and Liver Physiology, 2018, 315 (5), pp.G671-G684. ⟨10.1152/ajpgi.00348.2017⟩
Endogenous glucagon-like peptide-1 (GLP-1) regulates glucose-induced insulin secretion through both direct β-cell-dependent and indirect gut-brain axis-dependent pathways. However, little is known about the mode of action of the GLP-1 receptor agoni
Autor:
Thierry Sulpice, Rémy Burcelin, François Briand, Aurélie Waget, Vincent Azalbert, Lucile Garidou, Céline Garret, Céline Pomié, Benjamin Lelouvier, Julie Charpentier, Pascale Klopp, Florence Servant, Victorine Douin-Echinard
Publikováno v:
Acta Diabetologica.
The intestinal microbiota to immune system crosstalk is a major regulator of metabolism and hence metabolic diseases. An impairment of the chemokine receptor CX3CR1, as a key regulator shaping intestinal microbiota under normal chow feeding, could be
Autor:
Frédéric Lopez, Céline Pomié, Anthony Puel, Vincent Blasco-Baque, Lucile Garidou, Philippe Valet, Michael Courtney, Rémy Burcelin, Aurélie Waget, Jacques Amar, Vincent Azalbert, Benjamin Lelouvier, Florence Servant, Pascale Klopp, Simon Nicolas, Cédric Dray, Pascale Loubieres
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 5, Iss 6, Pp 392-403 (2016)
Molecular Metabolism, Vol 5, Iss 6, Pp 392-403 (2016)
Objective To demonstrate that glycemia and insulin resistance are controlled by a mechanism involving the adaptive immune system and gut microbiota crosstalk. Methods We triggered the immune system with microbial extracts specifically from the intest
Autor:
Pascale Klopp, Simon Nicolas, Matteo Serino, Pascale Loubieres, Rémy Burcelin, Céline Pomié, André Colom, Martine Bonnaure-Mallet, Vincent Blasco-Baque, Sandrine Le Gall-David, Vincent Azalbert, Mathieu Lemaitre, Quentin Escoula, Aurélie Waget, Lucile Garidou, Philippe Kémoun
Publikováno v:
Gut
Gut, BMJ Publishing Group, 2017, 66 (5), pp.872-885. ⟨10.1136/gutjnl-2015-309897⟩
Gut, 2017, 66 (5), pp.872-885. ⟨10.1136/gutjnl-2015-309897⟩
Gut, BMJ Publishing Group, 2017, 66 (5), pp.872-885. ⟨10.1136/gutjnl-2015-309897⟩
Gut, 2017, 66 (5), pp.872-885. ⟨10.1136/gutjnl-2015-309897⟩
International audience; OBJECTIVE: To identify a causal mechanism responsible for the enhancement of insulin resistance and hyperglycaemia following periodontitis in mice fed a fat-enriched diet. DESIGN: We set-up a unique animal model of periodontit
Autor:
Mathieu Bergé, Aurélie Waget, Philippe J. Sansonetti, Natalia F. Smirnova, Thierry Sulpice, Rémy Burcelin, Philippe Langella, Luis G. Bermúdez-Humarán, Nina Rautonen, Christelle Vachoux, Jacques Amar, Pascale Klopp, Chantal Chabo, Arthur C. Ouwehand, Sampo J. Lahtinen
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, 2011, 3 (9), pp.559-72. ⟨10.1002/emmm.201100159⟩
EMBO Molecular Medicine; Vol 3
EMBO Molecular Medicine, Wiley Open Access, 2011, 3 (9), pp.559-72. ⟨10.1002/emmm.201100159⟩
EMBO Molecular Medicine 9 (3), 559-572. (2011)
EMBO Molecular Medicine, 2011, 3 (9), pp.559-72. ⟨10.1002/emmm.201100159⟩
EMBO Molecular Medicine; Vol 3
EMBO Molecular Medicine, Wiley Open Access, 2011, 3 (9), pp.559-72. ⟨10.1002/emmm.201100159⟩
EMBO Molecular Medicine 9 (3), 559-572. (2011)
International audience; A fat-enriched diet modifies intestinal microbiota and initiates a low-grade inflammation, insulin resistance and type-2 diabetes. Here, we demonstrate that before the onset of diabetes, after only one week of a high-fat diet
Autor:
Florence Servant, Philippe Valet, Jacques Amar, Matteo Serino, Julie Charpentier, Meryem Aloulou, Nicolas Fazilleau, Anaïs Giry, Michael Courtney, Gérard Eberl, Céline Pomié, Rémy Burcelin, Benjamin Lelouvier, Pascale Klopp, Xavier Collet, Lotta Stenman, Sampo J. Lahtinen, Victorine Douin-Echinard, Christophe Heymes, Cédric Dray, Aurélie Waget, Jason S. Iacovoni, Lucile Garidou
Publikováno v:
Cell Metabolism
Cell Metabolism, Elsevier, 2015, 22 (1), pp.100-112. ⟨10.1016/j.cmet.2015.06.001⟩
Cell Metabolism, 2015, 22 (1), pp.100-112. ⟨10.1016/j.cmet.2015.06.001⟩
Cell Metabolism, Elsevier, 2015, 22 (1), pp.100-112. ⟨10.1016/j.cmet.2015.06.001⟩
Cell Metabolism, 2015, 22 (1), pp.100-112. ⟨10.1016/j.cmet.2015.06.001⟩
SummaryA high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in response to changes in the intestinal microbiota through as-yet-unknown mechanisms. Here, we show that a HFD-derived ileum microbiota is responsible for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20825fa1044e18e8e2a526d77f047bc3
https://www.hal.inserm.fr/inserm-02439884
https://www.hal.inserm.fr/inserm-02439884