Výsledky vyhledávání - "Pascale Gaillard"

AS601245, a c-Jun NH2 -terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils

Autor: Sonia Carboni, Pascale Gaillard, P-A Vitte, U Boschert, J-Y Gillon, J-P Gotteland

Publikováno v: British Journal of Pharmacology. 153:157-163

Based on their proven ability, in animal models of stroke, to reduce damage to brain grey matter, many drugs have been tested in clinical trials but without success. Failure to save axons from injury and to protect functional outcome has been propose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09ca0f0984090646b1baa9f6f1c0bed3
https://doi.org/10.1038/sj.bjp.0707574

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A Cellular Assay for Measuring the Inhibition of Glycogen Synthase Kinase-3 via the Accumulation of β-Catenin in Chinese Hamster Ovary Clone K1 Cells

Autor: Alexander Scheer, Paul Lang, Pascale Gaillard, Jean-Pierre Gotteland, Laurence Novo-Perez, Patrick Page, Karen Yeow

Publikováno v: ASSAY and Drug Development Technologies. 4:451-460

Glycogen synthase kinase-3 (GSK3) is a serine-threonine protein kinase that exists as two isozymes, GSK3alpha and GSK3beta. It plays important roles in regulating cell structure, function, and survival, and dysregulation of its function is linked to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd65c3dfaaa014652d73b9b357dd5568
https://doi.org/10.1089/adt.2006.4.451

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Synthesis of Novel C-Methylflavones

Autor: Mourad Kaouadji, Pascale Gaillard, Marcelle Hauteville, Marie-Christine Duclos

Publikováno v: Liebigs Annalen. 1996:1217-1222

If the Baker-Venkataraman rearrangement of C-methylphloracetophenone triaroyl esters is carried out in DMSO with powdered NaOH, the result greatly depends on the substitution pattern both of the phloracetophenone moiety possessing either one or two C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea5d68e168c4888f3beb8ed13facefcf
https://doi.org/10.1002/jlac.199619960724

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Design and Synthesis of the First Generation of Novel Potent, Selective, and in Vivo Active (Benzothiazol-2-yl)acetonitrile Inhibitors of the c-Jun N-Terminal Kinase

Autor: Steve Arkinstall, Pascale Gaillard, Denise Gretener, Cedric Szyndralewiez, Dennis Church, Christian Chabert, Vittoria Ardissone, Rocco Cirillo, Jean-Pierre Gotteland, Isabelle Jeanclaude-Etter, Montserrat Camps, Serge Halazy, Yves Cambet, Anthony Nichols, Pierre-Alain Vitte

Publikováno v: Journal of Medicinal Chemistry. 48:4596-4607

Several lines of evidence support the hypothesis that c-Jun N-terminal kinase (JNKs) plays a critical role in a wide range of diseases including cell death (apoptosis)-related disorders (neurodegenerative diseases, brain, heart, and renal ischemia, e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593ef4b1117216c3b2a9c68228a20564
https://doi.org/10.1021/jm0310986

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Control of death receptor and mitochondrial-dependent apoptosis by c-Jun N-terminal kinase in hippocampal CA1 neurones following global transient ischaemia

Autor: Jean-Pierre Gotteland, Sonia Carboni, Bruno Antonsson, Pascale Gaillard, Jean-Yves Gillon, Pierre-Alain Vitte

Publikováno v: Journal of Neurochemistry. 92:1054-1060

c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase family, is activated in response to a number of extracellular stimuli, including inflammatory cytokines, UV irradiation and ischaemia. A large body of evidence supports a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ae51301d83d3f10c218daeed06d4e99
https://doi.org/10.1111/j.1471-4159.2004.02925.x

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Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats

Autor: Pierre-Alain Vitte, Sonia Carboni, Jean-Pierre Gotteland, Claudio Giachetti, Rocco Cirillo, Pascale Gaillard, Rossana Ballerio, Chiara Ferrandi

Publikováno v: British Journal of Pharmacology. 142:953-960

1 Myocardial ischemia/reperfusion is associated with inflammation, apoptosis and necrosis. During this process, c-jun N-terminal kinase is activated in cardiac myocytes resulting in apoptosis. 2 This study investigates the effects of AS601245, a nonp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d5926de72f89b3a706103b60215daf4
https://doi.org/10.1038/sj.bjp.0705873

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ChemInform Abstract: A Novel Synthesis of 1-(2,4,6-Trihydroxy-3,5-dimethylphenyl)ethanone ( Di-C-methylphloracetophenone) and Two New Non-Aromatic C-Benzylated Derivatives

Autor: Marie-Christine Duclos, Pascale Gaillard, M. Hauteville, Rolf Stomberg

Publikováno v: ChemInform. 26

The synthesis of the title compound 1e was achieved by an easy three-step procedure from 1,3,5-benzenetriol (1a, phloroglucinol). Compound 1a was C-methylated using MeI. The crude mixture obtained was acetylated to give 1d which was converted into 1e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb99c881db0ae5cb2e882087a3ad9340
https://doi.org/10.1002/chin.199550070

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ChemInform Abstract: Selective Inhibition of Rat Heart cAMP Phosphodiesterases by Lipophilic C-Methyl-2-phenyl-4H-1-benzopyran-4-ones (C-Methylflavones)

Autor: Pascale Gaillard, Annie-France Prigent, Marcelle Hauteville, Madeleine Picq, Marie-Christine Duclos, Madeleine Dubois

Publikováno v: ChemInform. 28

A series of eight methoxylated C-methyl-2-phenyl-4H-1-benzopyran-4-ones 3, 6, 10-15 was evaluated as inhibitors of rat heart cytosolic cyclic nucleotide phosphodiesterase (PDE). The 2-(3, 4-dimethoxyphenyl)-5, 7-dimethoxy-3, 8-dimethyl-4H-1-benzopyra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d240d2cf2b90de47ea433f58ec0fb05f
https://doi.org/10.1002/chin.199711114

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