Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Pascale G. Charest"'
Autor:
Hannah R. Ortiz, Paola Cruz Flores, Julia Podgorski, Aaron Ramonett, Tasmia Ahmed, Nadine Hempel, Pascale G. Charest, Nathan A. Ellis, Paul R. Langlais, William R. Montfort, Karthikeyan Mythreye, Sanjay Kumar, Nam Y. Lee
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 53, Iss , Pp 101003- (2024)
Dynamic changes in the endoplasmic reticulum (ER) morphology are central to maintaining cellular homeostasis. Microtubules (MT) facilitate the continuous remodeling of the ER network into sheets and tubules by coordinating with many ER-shaping protei
Externí odkaz:
https://doaj.org/article/274b38172af341548cf9d7362df38b4a
Autor:
Shannon E. Collins, Mollie E. Wiegand, Alyssa N. Werner, Isabella N. Brown, Mary I. Mundo, Douglas J. Swango, Ghassan Mouneimne, Pascale G. Charest
Publikováno v:
Molecular Biology of the Cell. 34
Ras regulation of mTORC2 in breast epithelial and cancer cells promotes their migration, and mTORC2 mediates the invasion but not the proliferation of breast epithelial cells transformed with oncogenic Ras.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2550605d9677bf085c56a2993abd9e
https://doi.org/10.1091/mbc.e22-06-0236
https://doi.org/10.1091/mbc.e22-06-0236
Autor:
Mollie E. Wiegand, Shannon E. Collins, Isabella N. Brown, Alyssa N. Werner, Isabelle M. Mundo, Ghassan Mouneimne, Pascale G. Charest
Publikováno v:
Cancer Research. 82:2416-2416
We previously identified the mechanistic Target of Rapamycin Complex 2 (mTORC2) as an effector of Ras for the control of directed cell migration in Dictyostelium. Recently, this relationship was found to be conserved in mammalian cells, and mTORC2 wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a434e4fc0a0e5db1dff2c0d3a354d071
https://doi.org/10.1158/1538-7445.am2022-2416
https://doi.org/10.1158/1538-7445.am2022-2416
Publikováno v:
J Cell Sci
The Ras oncogene is notoriously difficult to target with specific therapeutics. Consequently, there is interest to better understand the Ras signaling pathways to identify potential targetable effectors. Recently, the mechanistic target of rapamycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4df18f5a31590bd70abf9c6c1ae3c0
https://europepmc.org/articles/PMC7561475/
https://europepmc.org/articles/PMC7561475/
Autor:
Wouter-Jan Rappel, Margarethakay Scavello, Pearce Haldeman, Haicen Yue, Pascale G. Charest, A. F. M. Tariqul Islam
Publikováno v:
Cellular Signalling. 48:25-37
To study the dynamics and mechanisms controlling activation of the heterotrimeric G protein Gα2βγ in Dictyostelium in response to stimulation by the chemoattractant cyclic AMP (cAMP), we monitored the G protein subunit interaction in live cells us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eee96ac4ccb4b95b95728bb0651b4a
https://doi.org/10.1016/j.cellsig.2018.04.005
https://doi.org/10.1016/j.cellsig.2018.04.005
Autor:
Inbal Hecht, Monica L Skoge, Pascale G Charest, Eshel Ben-Jacob, Richard A Firtel, William F Loomis, Herbert Levine, Wouter-Jan Rappel
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 6, p e1002044 (2011)
Many eukaryotic cells are able to crawl on surfaces and guide their motility based on environmental cues. These cues are interpreted by signaling systems which couple to cell mechanics; indeed membrane protrusions in crawling cells are often accompan
Externí odkaz:
https://doaj.org/article/afb2ea48273a404fadbf0be2a0267721
Autor:
Pascale G. Charest, Dustin Daniel, Margarethakay Scavello, Pouya Lotfi, Pearce Haldeman, A. F. M. Tariqul Islam
Publikováno v:
Mol Cell Biochem
Caffeine is commonly used in Dictyostelium to inhibit the synthesis of the chemoattractant cAMP and, therefore, its secretion and the autocrine stimulation of cells, in order to prevent its interference with the study of chemoattractant-induced respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1de42535b94d1c460f9057e31cbcb0
https://pubmed.ncbi.nlm.nih.gov/30879206
https://pubmed.ncbi.nlm.nih.gov/30879206
Autor:
Pouya Lotfi, Margarethakay Scavello, Ramya Ramesh, Pascale G. Charest, Alexandra R. Petlick, Valery F. Thompson
Publikováno v:
Journal of Cell Science.
Efficient directed migration requires tight regulation of chemoattractant signal transduction pathways in both space and time, but the mechanisms involved in such regulation are not well understood. Here, we investigated the role of Protein Kinase A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31fc28ecc3acf2a6a50bc74ec5be8535
https://doi.org/10.1242/jcs.177170
https://doi.org/10.1242/jcs.177170
Autor:
John M. Asara, Hirofumi Yoshino, Kosuke Takeda, Mika Sasaki, Pascale G. Charest, Dimitrios Anastasiou, Nazanin Majd, Kazutaka Sumita, Hidenori Takahashi, Atsuo T. Sasaki, Emily Rose Kahoud, Koh Takeuchi, Richard A. Firtel, Susan Lee, Taruho S. Kuroda
Publikováno v:
Journal of Biological Chemistry. 289:3950-3959
Mammalian cells encode three closely related Ras proteins, H-Ras, N-Ras, and K-Ras. Oncogenic K-Ras mutations frequently occur in human cancers, which lead to dysregulated cell proliferation and genomic instability. However, mechanistic role of the R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9687a62ec86b68bb66e2f236b07912
https://doi.org/10.1074/jbc.m113.531178
https://doi.org/10.1074/jbc.m113.531178
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1407
Understanding the dynamics of chemoattractant signaling is key to our understanding of the mechanisms underlying the directed migration of cells, including that of neutrophils to sites of infections and of cancer cells during metastasis. A model freq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::870701eb13e5dd17a06db4c72bdf7fc5
https://pubmed.ncbi.nlm.nih.gov/27271894
https://pubmed.ncbi.nlm.nih.gov/27271894