Modulating uranium binding affinity in engineered calmodulin EF-hand peptides: effect of phosphorylation.

Autor: Romain Pardoux, Sandrine Sauge-Merle, David Lemaire, Pascale Delangle, Luc Guilloreau, Jean-Marc Adriano, Catherine Berthomieu

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e41922 (2012)

To improve our understanding of uranium toxicity, the determinants of uranyl affinity in proteins must be better characterized. In this work, we analyzed the contribution of a phosphoryl group on uranium binding affinity in a protein binding site, us

Externí odkaz: https://doaj.org/article/ade5323594064ee59dabc4e14c12339b

A Series of Ni Complexes Based on a Versatile ATCUN-Like Tripeptide Scaffold to Decipher Key Parameters for Superoxide Dismutase Activity

Autor: Jérémy Domergue, Pawel Guinard, Magali Douillard, Jacques Pécaut, Sarah Hostachy, Olivier Proux, Colette Lebrun, Alan Le Goff, Pascale Maldivi, Carole Duboc, Pascale Delangle

Publikováno v: Inorganic Chemistry.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f28e2c15f62afdb0e75f90cb3c73022
https://doi.org/10.1021/acs.inorgchem.3c00766

A Simple Fluorescence Affinity Assay to Decipher Uranyl-Binding to Native Proteins

Autor: Fanny Laporte, Yves Chenavier, Alexandra Botz, Christelle Gateau, Colette Lebrun, Sarah Hostachy, Claude Vidaud, Pascale Delangle

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2022, 61 (26), ⟨10.1002/anie.202203198⟩

Determining the affinity of proteins for uranyl is key to understand the toxicity of this cation and to further develop decorporation strategies. However, usual techniques to achieve that goal often require specific equipment and expertise. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a581505611dcfcacc59daa662acdff69
https://pubmed.ncbi.nlm.nih.gov/35466512

Determination of the affinity of biomimetic peptides for uranium through the simultaneous coupling of HILIC to ESI-MS and ICP-MS

Autor: Lana Abou-Zeid, Albert Pell, Marta Garcia Cortes, Hélène Isnard, Pascale Delangle, Carole Bresson

Publikováno v: Analytica Chimica Acta
Analytica Chimica Acta, 2023, 1242, pp.340773. ⟨10.1016/j.aca.2022.340773⟩

International audience; Several proteins have been identified in the past decades as targets of uranyl (UO$_2$$^{2+}$) in vivo. However, the molecular interactions responsible for this affinity are still poorly known which requires the identification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5438b0b92bd9f731a56b9a49dce8cf75
https://doi.org/10.1016/j.aca.2022.340773

Citrulline stimulates muscle protein synthesis, by reallocating ATP consumption to muscle protein synthesis

Autor: Eric Fontaine, Pascale Delangle, Christophe Moinard, A. Goron, Uwe Schlattner, Frédéric Lamarche, Sandrine Blanchet

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 4, Pp 919-928 (2019)
Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle, 2019, 10 (4), pp.919-928. ⟨10.1002/jcsm.12435⟩
Journal of Cachexia, Sarcopenia and Muscle, Wiley Open Access/Springer Verlag, 2019, 10 (4), pp.919-928. ⟨10.1002/jcsm.12435⟩

Background Animal studies and clinical data support the interest of citrulline as a promising therapeutic for sarcopenia. Citrulline is known to stimulate muscle protein synthesis, but how it affects energy metabolism to support the highly energy‐d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58daae20819de067a6dca74c1418f49c
https://doaj.org/article/cba6b4c746494e7eaf8270a526e88f65