Partial deletion of eNOS gene causes hyperinsulinemic state, unbalance of cardiac insulin signaling pathways and coronary dysfunction independently of high fat diet.

Autor: Cecilia Vecoli, Michela Novelli, Anna Pippa, Daniela Giacopelli, Pascale Beffy, Pellegrino Masiello, Antonio L'Abbate, Danilo Neglia

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104156 (2014)

Abnormalities in eNOS gene, possibly interacting with high fat diet (HFD), affect peripheral vascular function and glucose metabolism. The relative role of eNOS gene, HFD and metabolic derangement on coronary function has not been fully elucidated. W

Externí odkaz: https://doaj.org/article/1073de880fac4fc4bd5fb8502819b65f

Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets.

Autor: Luisa Martino, Matilde Masini, Michela Novelli, Pascale Beffy, Marco Bugliani, Lorella Marselli, Pellegrino Masiello, Piero Marchetti, Vincenzo De Tata

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36188 (2012)

We have investigated the in vitro effects of increased levels of glucose and free fatty acids on autophagy activation in pancreatic beta cells. INS-1E cells and isolated rat and human pancreatic islets were incubated for various times (from 2 to 24 h

Externí odkaz: https://doaj.org/article/2c7e460aeba2416fb7ed563c023705c1

Protective role of st. John’s wort and its components hyperforin and hypericin against diabetes through inhibition of inflammatory signaling: Evidence from in vitro and in vivo studies

Autor: Michela Novelli, Pellegrino Masiello, Pascale Beffy, Marta Menegazzi

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 8108, p 8108 (2020)

Diabetes mellitus is a very common chronic disease with progressively increasing prevalence. Besides the well-known autoimmune and inflammatory pathogenesis of type 1 diabetes, in many people, metabolic changes and inappropriate lifestyle favor a sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6f9602edb93d6b2f5cc305a993d988
http://hdl.handle.net/11568/1059057

Activation of the interferon type I response rather than autophagy contributes to myogenesis inhibition in congenital DM1 myoblasts

Autor: Virginia Pretini, Andrea Stoccoro, Milena Rizzo, Annalisa Botta, Renata Del Carratore, Marcella Simili, Monica Evangelista, Fabio Coppedè, Pascale Beffy, Romina D'Aurizio, Alessandra Falleni, Denis Furling

Publikováno v: Cell death and disease 9 (2018). doi:10.1038/s41419-018-1080-1
info:cnr-pdr/source/autori:Rizzo M, Beffy P, Del Carratore R, Falleni A, Pretini V, D'Aurizio R, Botta A, Evangelista M, Stoccoro A, Coppedè F, Furling D, Simili M/titolo:Activation of the interferon type I response rather than autophagy contributes to myogenesis inhibition in congenital DM1 myoblasts/doi:10.1038%2Fs41419-018-1080-1/rivista:Cell death and disease/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:9
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2018, 9, ⟨10.1038/s41419-018-1080-1⟩
Cell Death and Disease, Vol 9, Iss 11, Pp 1-16 (2018)
Cell Death & Disease

Congenital myotonic dystrophy type 1 (CDM1) is characterized by severe symptoms that affect patients from birth, with 40% mortality in the neonatal period and impaired skeletal muscle development. In this paper, we examined the relationship between a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa0b8e5c274eb8c088167b6e7726ff8

The aryl receptor inhibitor epigallocatechin-3-gallate protects INS-1E beta-cell line against acute dioxin toxicity

Autor: Pascale Beffy, Luisa De Martino, Daniela Giacopelli, Matilde Masini, Michela Novelli, Pellegrino Masiello, V. De Tata

Publikováno v: Chemosphere. 93:1447-1455

The aim of this research was to investigate the mechanism(s) underlying the acute toxicity of dioxin in pancreatic beta cells and to evaluate the protective effects of epigallocatechin-3-gallate (EGCG), the most abundant of the green tea’s catechin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50aebf982cd69b3b1b9c69386cf3830b
https://doi.org/10.1016/j.chemosphere.2013.06.026