Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Pascal Wodtke"'
Autor:
Martin Grashei, Pascal Wodtke, Jason G. Skinner, Sandra Sühnel, Nadine Setzer, Thomas Metzler, Sebastian Gulde, Mihyun Park, Daniela Witt, Hermine Mohr, Christian Hundshammer, Nicole Strittmatter, Natalia S. Pellegata, Katja Steiger, Franz Schilling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract pH alterations are a hallmark of many pathologies including cancer and kidney disease. Here, we introduce [1,5-13C2]Z-OMPD as a hyperpolarized extracellular pH and perfusion sensor for MRI which allows to generate a multiparametric fingerpri
Externí odkaz:
https://doaj.org/article/e47e9472da1b44daad591e0e237537be
Measuring extracellular human brain pH and amino acid metabolism with hyperpolarized [1-13C]pyruvate
Autor:
Alixander S Khan, Mary A McLean, Joshua D Kaggie, Ines Horvat-Menih, Tomasz Matys, Rolf F Schulte, Matthew J Locke, Ashley Grimmer, Pascal Wodtke, Elizabeth Latimer, Amy Frary, Martin J Graves, Ferdia A Gallagher
Hyperpolarized carbon-13 MRI has shown promise for non-invasive assessment of the cerebral metabolism of [1-13C]pyruvate in both healthy volunteers and in patients. Exchange of pyruvate to lactate catalyzed by lactate dehydrogenase (LDH), and pyruvat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::475fb61069e14bbd5845c656f7dff61a
https://doi.org/10.1101/2023.03.23.23287579
https://doi.org/10.1101/2023.03.23.23287579
