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Autor:
Etienne Sonveaux, Michel Claesen, Pascal Scrève, Isabelle Paternotte, Hua Juan Fan, Paul M. Tulkens
Publikováno v:
Bioorganicmedicinal chemistry. 9(2)
Readily hydrolysable basic and dibasic esters of ampicillin were synthesised by alkylation of the carboxylate function of ampicillin to obtain prodrugs that may accumulate in cells and allow for an intracellular delivery of ampicillian (Fan et al., B