Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Pascal Schulthess"'
Autor:
Federico Bolognani, Matthias Machacek, Annelieke Kruithof, Marieke de Kam, Kirsten Bergmann, Max van Gent, Matthias Moerland, Pascal Crenn, Christian Meyer, Gerard Greig, Pim Gal, Pascal Schulthess
Publikováno v:
Transplantation. 106:S544-S544
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Drug dosing regimen can significantly impact drug effect and, thus, the success of treatments. Nevertheless, trial and error is still the most commonly used method by conventional pharmacometric approaches to optimize dosing regimen. In this tutorial
Autor:
Federico Bolognani, L. Santarelli, Pim Gal, Christian Meyer, Annelieke C. Kruithof, Pascal Schulthess, Matthijs Moerland, M. Machacek, M. van Gent, Gerard Greig
Publikováno v:
Clinical Nutrition ESPEN. 40:413-414
Autor:
Gerard Greig, Pascal Schulthess, Matthias Machacek, Federico Bolognani, Max van Gent, Marieke L. de Kam, Pascal Crenn, Pim Gal, Annelieke C. Kruithof, Matthijs Moerland, Kirsten R. Bergmann, Christian Meyer
Publikováno v:
Gastroenterology. 160:S-738
Publikováno v:
Chemie Ingenieur Technik. 89:440-446
Autor:
Piet H. van der Graaf, Rob C. van Wijk, James W.T. Yates, Pascal Schulthess, Herman P. Spaink, Elke H. J. Krekels
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
To advance the systems approach in pharmacology, experimental models and computational methods need to be integrated from early drug discovery onward. Here, we propose outside‐in model development, a model identification technique to understand and
Publikováno v:
The AAPS Journal
Thorough exploration of alternative dosing frequencies is often not performed in conventional pharmacometrics approaches. Quantitative systems pharmacology (QSP) can provide novel insights into optimal dosing regimen and drug behaviors which could ad
Autor:
Pascal, Schulthess, Rob C, van Wijk, Elke H J, Krekels, James W T, Yates, Herman P, Spaink, Piet H, van der Graaf
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
To advance the systems approach in pharmacology, experimental models and computational methods need to be integrated from early drug discovery onward. Here, we propose outside‐in model development, a model identification technique to understand and
Autor:
Albert Braeuning, Pascal Schulthess, Alexandra Löffler, Michael Schwarz, Nils Blüthgen, Silvia Vetter, Luisa Kreft
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 43(11), 5318--5330
Nucleic Acids Research, 43(11), 5318--5330
Genes involved in detoxification of foreign compounds exhibit complex spatiotemporal expression patterns in liver. Cytochrome P450 1A1 (CYP1A1), for example, is restricted to the pericentral region of liver lobules in response to the interplay betwee
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Drug dosing regimen can significantly impact drug effect and, thus, the success of treatments. Nevertheless, trial and error is still the most commonly used method by conventional pharmacometric approaches to optimize dosing regimen. In this tutorial