Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pascal Pucholt"'
Autor:
Henrik R. Hallingbäck, Pascal Pucholt, Pär K. Ingvarsson, Ann Christin Rönnberg-Wästljung, Sofia Berlin
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Sex chromosomes are in some species largely undifferentiated (homomorphic) with restricted sex determination regions. Homomorphic but different sex chromosomes are found in the closely related genera Populus and Salix indicating f
Externí odkaz:
https://doaj.org/article/f1988780e84c40db914cd1279856b4b3
Autor:
Elisabet Svenungsson, Iva Gunnarsson, Lars Rönnblom, Joanne Nititham, Lindsey A Criswell, Cristina M Lanata, Andreas Jönsen, Christopher Sjöwall, Solbritt Rantapää-Dahlqvist, Sule Yavuz, Dag Leonard, Maija-Leena Eloranta, Johanna K Sandling, Karin Bolin, Anders A Bengtsson, Juliana Imgenberg-Kreuz, Pascal Pucholt, Matteo Bianchi, Kerstin Lindblad-Toh, Sergey V Kozyrev
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss 1 (2022)
Objective Lupus nephritis (LN) is a common and severe manifestation of SLE. The genetic risk for nephritis and progression to end-stage renal disease (ESRD) in patients with LN remains unclear. Herein, we aimed to identify novel genetic associations
Externí odkaz:
https://doaj.org/article/0bc5209e6cae41659a006e2eac9c490d
Autor:
Pedro Almeida, Estelle Proux-Wera, Allison Churcher, Lucile Soler, Jacques Dainat, Pascal Pucholt, Jessica Nordlund, Tom Martin, Ann-Christin Rönnberg-Wästljung, Björn Nystedt, Sofia Berlin, Judith E. Mank
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-18 (2020)
Abstract Background Sex chromosomes have evolved independently multiple times in eukaryotes and are therefore considered a prime example of convergent genome evolution. Sex chromosomes are known to emerge after recombination is halted between a homol
Externí odkaz:
https://doaj.org/article/7f179dc3f8074d93a4be7aa36059b0ee
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-11 (2020)
Abstract Objective Patients with systemic lupus erythematosus (SLE) have an ongoing interferon (IFN) production due to an activation of plasmacytoid dendritic cells (pDCs), which can be triggered to type I IFN synthesis by RNA containing immune compl
Externí odkaz:
https://doaj.org/article/b893a44d534e463f8a6c8c524aa64ac7
Autor:
Christian Lundtoft, Pascal Pucholt, Juliana Imgenberg-Kreuz, Jonas Carlsson-Almlöf, Maija-Leena Eloranta, Ann-Christine Syvänen, Gunnel Nordmark, Johanna K Sandling, Ingrid Kockum, Tomas Olsson, Lars Rönnblom, Niklas Hagberg
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009199 (2020)
Interferons (IFNs) are cytokines that are central to the host defence against viruses and other microorganisms. If not properly regulated, IFNs may contribute to the pathogenesis of inflammatory autoimmune, or infectious diseases. To identify genetic
Externí odkaz:
https://doaj.org/article/84e1ff3a682f4b78bec23eda995a9815
Autor:
Helena Idborg, Arash Zandian, Elena Ossipova, Edvard Wigren, Charlotta Preger, Fariborz Mobarrez, Antonio Checa, Azita Sohrabian, Pascal Pucholt, Johanna K. Sandling, Cátia Fernandes-Cerqueira, Johan Rönnelid, Vilija Oke, Giorgia Grosso, Marika Kvarnström, Anders Larsson, Craig E. Wheelock, Ann-Christine Syvänen, Lars Rönnblom, Kim Kultima, Helena Persson, Susanne Gräslund, Iva Gunnarsson, Peter Nilsson, Elisabet Svenungsson, Per-Johan Jakobsson
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease, which currently lacks specific diagnostic biomarkers. The diversity within the patients obstructs clinical trials but may also reflect differences in underlying pathogenesis. O
Externí odkaz:
https://doaj.org/article/6f325af014d94b0386831770ead16b27
Autor:
Andrius Serva, Pranas Grigaitis, Ursula Kummer, Vytaute Starkuviene, Ursula Rost, Pascal Pucholt
Publikováno v:
RNA Biol
Grigaitis, P, Starkuviene, V, Rost, U, Serva, A, Pucholt, P & Kummer, U 2020, ' miRNA target identification and prediction as a function of time in gene expression data ', RNA Biology, vol. 17, no. 7, pp. 990-1000 . https://doi.org/10.1080/15476286.2020.1748921
RNA Biology, 17(7), 990-1000. Landes Bioscience
Grigaitis, P, Starkuviene, V, Rost, U, Serva, A, Pucholt, P & Kummer, U 2020, ' miRNA target identification and prediction as a function of time in gene expression data ', RNA Biology, vol. 17, no. 7, pp. 990-1000 . https://doi.org/10.1080/15476286.2020.1748921
RNA Biology, 17(7), 990-1000. Landes Bioscience
The understanding of miRNA target interactions is still limited due to conflicting data and the fact that high-quality validation of targets is a time-consuming process. Faster methods like high-throughput screens and bioinformatics predictions are e
Autor:
Robert G. Cooper, Ingrid E. Lundberg, Simon Rothwell, Lina Hultin Rosenberg, Maryam Dastmalchi, Anna Tjärnlund, Øyvind Molberg, Jennifer R. S. Meadows, Antonella Notarnicola, Matteo Bianchi, Sergey V. Kozyrev, Helena Andersson, Lars Rönnblom, Hector Chinoy, Johanna K. Sandling, Louise C. Pyndt Raun Diederichsen, Kerstin Lindblad-Toh, Andrei Alexsson, Pascal Pucholt, Leonid Padyukov, Janine A. Lamb, Åsa Karlsson
Publikováno v:
Bianchi, M, Kozyrev, S V, Notarnicola, A, Hultin Rosenberg, L, Karlsson, Å, Pucholt, P, Rothwell, S, Alexsson, A, Sandling, J K, Andersson, H, Cooper, R G, Padyukov, L, Tjärnlund, A, Dastmalchi, M, Meadows, J R S, Pyndt Diederichsen, L, Molberg, Ø, Chinoy, H, Lamb, J, Rönnblom, L, Lindblad-Toh, K, Lundberg, I E & ImmunoArray Development Consortium 2022, ' Contribution of Rare Genetic Variation to Disease Susceptibility in a Large Scandinavian Myositis Cohort ', Arthritis & Rheumatology, vol. 74, no. 2, pp. 342-352 . https://doi.org/10.1002/art.41929
OBJECTIVE: Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of complex autoimmune conditions characterized by inflammation in skeletal muscle and extramuscular compartments, and interferon (IFN) system activation. We undertook this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a1d4271de81ae3e380011e6f6c7321
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458674
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458674
Autor:
Sofia Berlin, Ann-Christin Rönnberg-Wästljung, Pascal Pucholt, Henrik R. Hallingbäck, Pär K. Ingvarsson
Publikováno v:
BMC Genomics
BMC Genomics, Vol 22, Iss 1, Pp 1-14 (2021)
BMC Genomics, Vol 22, Iss 1, Pp 1-14 (2021)
Background Sex chromosomes are in some species largely undifferentiated (homomorphic) with restricted sex determination regions. Homomorphic but different sex chromosomes are found in the closely related genera Populus and Salix indicating flexible s
Autor:
Ann-Christine Syvänen, Anne Troldborg, Christopher Sjöwall, Dag Leonard, Sarah Reid, Anne Voss, Niklas Hagberg, Elisabet Svenungsson, Anders A. Bengtsson, Andreas Jönsen, Søren Jacobsen, Lars Rönnblom, Øyvind Molberg, Pascal Pucholt, Iva Gunnarsson, Karoline Lerang, Andrei Alexsson, Johanna K. Sandling
Publikováno v:
Reid, S, Hagberg, N, Sandling, J K, Alexsson, A, Pucholt, P, Sjöwall, C, Lerang, K, Jönsen, A, Gunnarsson, I, Syvänen, A-C, Troldborg, A M, Voss, A, Bengtsson, A A, Molberg, Ø, Jacobsen, S, Svenungsson, E, Rönnblom, L & Leonard, D 2021, ' Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus ', Annals of the Rheumatic Diseases, vol. 80, no. 9, pp. 1183-1189 . https://doi.org/10.1136/annrheumdis-2020-219727
Reid, S, Hagberg, N, Sandling, J K, Alexsson, A, Pucholt, P, Sjöwall, C, Lerang, K, Jönsen, A, Gunnarsson, I, Syvänen, A C, Troldborg, A M, Voss, A, Bengtsson, A A, Molberg, Ø, Jacobsen, S, Svenungsson, E, Rönnblom, L & Leonard, D 2021, ' Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus ', Annals of the rheumatic diseases, vol. 80, no. 9, pp. 1183-1189 . https://doi.org/10.1136/annrheumdis-2020-219727
Reid, S, Hagberg, N, Sandling, J K, Alexsson, A, Pucholt, P, Sjöwall, C, Lerang, K, Jönsen, A, Gunnarsson, I, Syvänen, A C, Troldborg, A M, Voss, A, Bengtsson, A A, Molberg, Ø, Jacobsen, S, Svenungsson, E, Rönnblom, L & Leonard, D 2021, ' Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus ', Annals of the Rheumatic Diseases, vol. 80, no. 9, pp. 1183–1189 . https://doi.org/10.1136/annrheumdis-2020-219727
Annals of the Rheumatic Diseases
Reid, S, Hagberg, N, Sandling, J K, Alexsson, A, Pucholt, P, Sjöwall, C, Lerang, K, Jönsen, A, Gunnarsson, I, Syvänen, A C, Troldborg, A M, Voss, A, Bengtsson, A A, Molberg, Ø, Jacobsen, S, Svenungsson, E, Rönnblom, L & Leonard, D 2021, ' Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus ', Annals of the rheumatic diseases, vol. 80, no. 9, pp. 1183-1189 . https://doi.org/10.1136/annrheumdis-2020-219727
Reid, S, Hagberg, N, Sandling, J K, Alexsson, A, Pucholt, P, Sjöwall, C, Lerang, K, Jönsen, A, Gunnarsson, I, Syvänen, A C, Troldborg, A M, Voss, A, Bengtsson, A A, Molberg, Ø, Jacobsen, S, Svenungsson, E, Rönnblom, L & Leonard, D 2021, ' Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus ', Annals of the Rheumatic Diseases, vol. 80, no. 9, pp. 1183–1189 . https://doi.org/10.1136/annrheumdis-2020-219727
Annals of the Rheumatic Diseases
ObjectiveTo investigate how genetics influence the risk of smoking-related systemic lupus erythematosus (SLE) manifestations.MethodsPatients with SLE (ndiscovery cohort=776, nreplication cohort=836) were genotyped using the 200K Immunochip single nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ef27ed8961933399a4cb6353c326e1
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-178731
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-178731