Using Experimental Models to Decipher the Effects of Acetaminophen and NSAIDs on Reproductive Development and Health

Autor: Brigitte Boizet-Bonhoure, Stéphanie Déjardin, Moïra Rossitto, Francis Poulat, Pascal Philibert

Publikováno v: Frontiers in Toxicology, Vol 4 (2022)

Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin (acetylsalicylic acid), diclofenac and ibuprofen (IBU), and analgesic drugs, such as acetaminophen (APAP, or paracetamol), are widely used to treat inflammation and pain. APAP and IBU are

Externí odkaz: https://doaj.org/article/1b4812b367d548a1a7a2710bf47344e2

Screening of MAMLD1 mutations in 70 children with 46,XY DSD: identification and functional analysis of two new mutations.

Autor: Nicolas Kalfa, Maki Fukami, Pascal Philibert, Francoise Audran, Catherine Pienkowski, Jacques Weill, Graziella Pinto, Sylvie Manouvrier, Michel Polak, Totsumo Ogata, Charles Sultan

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32505 (2012)

More than 50% of children with severe 46,XY disorders of sex development (DSD) do not have a definitive etiological diagnosis. Besides gonadal dysgenesis, defects in androgen biosynthesis, and abnormalities in androgen sensitivity, the Mastermind-lik

Externí odkaz: https://doaj.org/article/b6739948cbb944c5b011f68027fa6ca8

How Far Should We Explore Hypospadias? Next-generation Sequencing Applied to a Large Cohort of Hypospadiac Patients

Autor: Charles Sultan, Jean Breaud, Nicolas Kalfa, Alice Faure, Nadège Servant-Fauconnet, Françoise Paris, Laura Gaspari, Anne Bergougnoux, Vuthy Ea, Pascal Philibert

Publikováno v: European Urology. 79:507-515

Background Next-generation sequencing (NGS) is generally used for patients with severe disorders of sex development (DSD). However, NGS has not been applied extensively for patients with hypospadias only, and most affected children do not benefit fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5b477a1ce012291d58bcd879880ac58
https://doi.org/10.1016/j.eururo.2020.12.036

The quantitative ultrasound method for assessing low bone mass in women with anorexia nervosa

Autor: Laura Gaspari, Denis Mariano-Goulart, Rémi Doré, Patrick Lefebvre, Maude Seneque, Eric Renard, Philippe Courtet, Didier Laux, Sébastien Guillaume, Pascal Philibert, Laurent Maïmoun, Krishna Kunal Mahadea, Charles Sultan, Ariane Sultan, Marie Picot, Helena Huguet, Vincent Boudousq

Publikováno v: Archives of Osteoporosis
Archives of Osteoporosis, Springer Verlag, 2021, 16 (1), ⟨10.1007/s11657-020-00870-w⟩
Archives of Osteoporosis, 2021, 16 (1), ⟨10.1007/s11657-020-00870-w⟩

International audience; This study investigated the potential role of quantitative ultrasound (QUS) to assess low bone mass in anorexia nervosa patients (AN). Bone parameters from QUS and DXA were positively correlated and significantly reduced in AN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbac278b8fde4287e924c29b26e163b8
https://hal.archives-ouvertes.fr/hal-03112259

In the mouse, prostaglandin D2 signalling protects the endometrium against adenomyosis

Autor: Francis Poulat, Alain Pruvost, Stephanie Dejardin, Nelly Pirot, Anvi Laetitia Nguyen, Pascal Philibert, Brigitte Boizet-Bonhoure, Florence Bernex

Publikováno v: Molecular Human Reproduction
Molecular Human Reproduction, Oxford University Press (OUP), 2021, 27 (5), ⟨10.1093/molehr/gaab029⟩
Molecular Human Reproduction, Oxford University Press (OUP), 2021, 27 (5), ⟨10.1093/molehr/gaab029/6225287⟩
Molecular Human Reproduction, 2021, 27 (5), ⟨10.1093/molehr/gaab029⟩

Adenomyosis is characterised by epithelial gland and mesenchymal stroma invasion of the uterine myometrium. Adenomyosis is an oestrogen-dependent gynaecological disease in which a number of factors, such as inflammatory molecules, prostaglandins (PGs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eabca8efd52208d0eb65fc4307abf06
https://doi.org/10.1093/molehr/gaab029