Výsledky vyhledávání - "Pascal Mettens"

Akademický článek

Heterologous prime-boost regimens with a recombinant chimpanzee adenoviral vector and adjuvanted F4 protein elicit polyfunctional HIV-1-specific T-Cell responses in macaques.

Autor: Clarisse Lorin, Yannick Vanloubbeeck, Sébastien Baudart, Michaël Ska, Babak Bayat, Geoffroy Brauers, Géraldine Clarinval, Marie-Noëlle Donner, Martine Marchand, Marguerite Koutsoukos, Pascal Mettens, Joe Cohen, Gerald Voss

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0122835 (2015)

HIV-1-specific CD4+ and CD8+ T lymphocytes are important for HIV-1 replication control. F4/AS01 consists of F4 recombinant fusion protein (containing clade B Gag/p24, Pol/RT, Nef and Gag/p17) formulated in AS01 Adjuvant System, and was shown to induc

Externí odkaz: https://doaj.org/article/a7095b2a8d4e4a7c8d855ef71a5c01ac

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Akademický článek

Quais (im)posturas intelectuais? O erro de Darwin

Autor: Pascal Mettens, Roland Gori

Publikováno v: Revista Latinoamericana de Psicopatologia Fundamental, Vol 3, Iss 3, Pp 46-72

Neste texto busca-se uma teorização do sujeito a partir da psicanálise, do estruturalismo e da noção de pós-modernidade. Os autores propõem-se, aqui, a mostrar como e por que um ocultamento da questão do sujeito incessantemente retorna e cond

Externí odkaz: https://doaj.org/article/068b53f376e84fb0847cfeb6245d0505

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Induction and Regulation of T-Cell Immunity by the Novel Tuberculosis Vaccine M72/AS01 in South African Adults

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 188:492-502

Tuberculosis (TB) is a major cause of morbidity and mortality worldwide, thus there is an urgent need for novel TB vaccines.We investigated a novel TB vaccine candidate, M72/AS01, in a phase IIa trial of bacille Calmette-Guérin-vaccinated, HIV-uninf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06519a172be42be28697eb56ca0831b
https://doi.org/10.1164/rccm.201208-1385oc

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Toxicology, biodistribution and shedding profile of a recombinant measles vaccine vector expressing HIV-1 antigens, in cynomolgus macaques

Autor: Gerald Voss, Nicolas Dumey, Johann Mols, Olga Rovira, Clarisse Lorin, Frédérick Le Goff, Patricia Bourguignon, Pascal Mettens, Frédéric Tangy, Jérémy Silvano, Lawrence Segal, Marguerite Koutsoukos, Danielle Morelle

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology

As a new human immunodeficiency virus type 1 (HIV-1) vaccine approach, the live-attenuated measles virus (MV) Schwarz vaccine strain was genetically engineered to express the F4 antigen (MV1-F4). F4 is a fusion protein comprising HIV-1 antigens p17 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a175799767cd4316d5942ae3fc71817c

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Les impasses de la dernière nosographie freudienne

Autor: Pascal Mettens

Publikováno v: Cahiers de psychologie clinique. :59-83

Resume Apres un examen minutieux des textes psychopathologiques du dernier Freud (de 1924 a 1938), l’auteur demontre, outre l’existence de psychoses sexuelles dans la derniere nosographie freudienne, que cette derniere englobe potentiellement tou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d73e55d518fd8a2a0428cf602f6161a
https://doi.org/10.3917/cpc.038.0059

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Identification and characterization of novel recombinant vaccine antigens for immunization against genitalChlamydia trachomatis

Autor: Peter Probst, Steven G. Reed, Joe Cohen, Pascal Mettens, Yves Lobet, Ajay Bhatia, Hang Fang, Pamela J. Ovendale, Rhea N. Coler, Brenda Barth, Jean-Francois Maisonneuve, Mark R. Alderson

Publikováno v: FEMS Immunology & Medical Microbiology. 55:258-270

Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection worldwide, with over 91 million cases estimated annually. An effective subunit vaccine against Chlamydia may require a multivalent subunit cocktail of antigen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a9004ead19ddf8fe5617784ec32ca4
https://doi.org/10.1111/j.1574-695x.2008.00527.x

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Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys

Autor: Steven G, Reed, Rhea N, Coler, Wilfried, Dalemans, Wilifred, Dalemans, Esterlina V, Tan, Eduardo C, DeLa Cruz, Randall J, Basaraba, Ian M, Orme, Yasir A W, Skeiky, Mark R, Alderson, Karen D, Cowgill, Jean-Paul, Prieels, Rodolfo M, Abalos, Marie-Claude, Dubois, Joe, Cohen, Pascal, Mettens, Yves, Lobet

Publikováno v: Proceedings of the National Academy of Sciences. 106:2301-2306

The development of a vaccine for tuberculosis requires a combination of antigens and adjuvants capable of inducing appropriate and long-lasting T cell immunity. We evaluated Mtb72F formulated in AS02A in the cynomolgus monkey model. The vaccine was i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71bfc80263994c93e638ff058fd9e781
https://doi.org/10.1073/pnas.0712077106

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Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS,S vaccine antigen

Autor: Nathalie Garçon, Patrice M. Dubois, Babak Bayat, V. Ann Stewart, Joe Cohen, D. Gray Heppner, Patricia Bourguignon, Marie-Ange Demoitié, Marie-Noelle Renelle Donner, Pascal Mettens

Publikováno v: Vaccine. 26:1072-1082

Protection against Plasmodium falciparum sporozoite infection can be achieved by vaccination with the recombinant circumsporozoite protein-based vaccine RTS,S formulated with the AS02A Adjuvant System. Since this protection is only partial and wanes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffa0f1c50d6da162426eca34123787a
https://doi.org/10.1016/j.vaccine.2007.12.018

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Preclinical Evaluation of the Safety and Immunogenicity of a Vaccine Consisting ofPlasmodium falciparumLiver-Stage Antigen 1 with Adjuvant AS01B Administered Alone or Concurrently with the RTS,S/AS01B Vaccine in Rhesus Primates

Autor: M. Gettayacamin, Kosol Yongvanitchit, Joe Cohen, Pascal Mettens, W. R. Ballou, U. Kum-Arb, M. M. Fukuda, Amporn Limsalakpetch, David E. Lanar, D. G. Heppner, V. A. Stewart, Lisa A. Ware, Sathit Pichyangkul

Publikováno v: Infection and Immunity. 76:229-238

Several lines of evidence suggest that targeting pre-erythrocytic-stage parasites for malaria vaccine development can provide sterile immunity. The objectives of this study were (i) to evaluate preclinically the safety and immunogenicity of a new rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7834f34f2a7f15b4ba6f245bcbd00b6b
https://doi.org/10.1128/iai.00977-07

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Priming with an Adenovirus 35-Circumsporozoite Protein (CS) Vaccine followed by RTS,S/AS01B Boosting Significantly Improves Immunogenicity to Plasmodium falciparum CS Compared to That with Either Malaria Vaccine Alone

Autor: Marie-Ange Demoitié, Maria G. Pau, Patrice M. Dubois, V. Ann Stewart, J. Robert Burge, Shannon McGrath, Babak Bayat, D. Gray Heppner, Pascal Mettens, Marie-Claude Dubois, Gerrit Jan Weverling, Jerome Custers, Jaap Goudsmit, Lisa A. Ware, Joseph P. Shott, David Larson, Michelle Cobb, Joe Cohen

Publikováno v: Infection and immunity, 75(5), 2283-2290. American Society for Microbiology

The RTS,S/AS02A protein-based vaccine consistently demonstrates significant protection against infection with Plasmodium falciparum malaria and also against clinical malaria and severe disease in children in areas of endemicity. Here we demonstrate w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2409965a85d401f75827a202e783dbfd
https://doi.org/10.1128/iai.01879-06

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