TLR7 Signaling Shapes and Maintains Antibody Diversity Upon Virus-Like Particle Immunization

Autor: Xinyue Chang, Pascal Krenger, Caroline C. Krueger, Lisha Zha, Jiami Han, Alexander Yermanos, Salony Roongta, Mona O. Mohsen, Annette Oxenius, Monique Vogel, Martin F. Bachmann

Publikováno v: Frontiers in Immunology, Vol 12 (2022)

Virus-like particles (VLPs) are used in different marketed vaccines and are able to induce potent antibody responses. The innate pattern recognition receptors TLR7/8 recognize single stranded (ss) RNA naturally packaged into some VLPs and have been s

Externí odkaz: https://doaj.org/article/a0cbcfa6cce04b98bd8fe8a4bb6bb77d

A scalable and highly immunogenic virus-like particle-based vaccine against SARS-CoV-2

Autor: Kevin Plattner, Anne-Cathrine S. Vogt, Aleksandra Nonic, Xinyue Chang, Romano Josi, Lee-Anne Brand, Villija Zeltina, Byron E. E. Martina, Katja Nuss, Xuelan Liu, Pascal Krenger, Thomas M. Kündig, Simon Zinkhan, Joana J. da Costa, Mona O. Mohsen, Senta M. Walton, Martin F. Bachmann, Ina Balke, Gary T. Jennings, Dominik Rothen, Jan M. Sobczak, Zahra Gharailoo, Gilles Sousa Augusto, Monique Vogel, Daniel E. Speiser, Marianne Zwicker, Andris Zeltins, Salony Roongta

Publikováno v: Allergy: European Journal of Allergy and Clinical Immunology, 77(1), 243-257. Wiley-Blackwell Publishing Ltd
Allergy
Mohsen, Mona O.; Balke, Ina; Zinkhan, Simon; Zeltina, Villija; Liu, Xuelan; Chang, Xinyue; Krenger, Pascal S.; Plattner, Kevin; Gharailoo, Zahra; Vogt, Anne-Cathrine S.; Augusto, Gilles; Zwicker, Marianne; Roongta, Salony; Rothen, Dominik A.; Josi, Romano; J. Da Costa, Joana; Sobczak, Jan M.; Nonic, Aleksandra; Brand, Lee-Anne; Nuss, Katja; ... (2022). A scalable and highly immunogenic virus-like particle-based vaccine against SARS-CoV-2. Allergy, 77(1), pp. 243-257. Wiley 10.1111/all.15080

Background SARS‐CoV‐2 caused one of the most devastating pandemics in the recent history of mankind. Due to various countermeasures, including lock‐downs, wearing masks, and increased hygiene, the virus has been controlled in some parts of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e264bb8109897f99484c42dcc0a2b6b
https://doi.org/10.1111/all.15080

AP205 VLPs Based on Dimerized Capsid Proteins Accommodate RBM Domain of SARS-CoV-2 and Serve as an Attractive Vaccine Candidate

Autor: Dominik Rothen, Mariliza Derveni, Kaspars Tars, Xuelan Liu, Salony Roongta, Xinyue Chang, Edward Wright, Pascal Krenger, Mona O. Mohsen, Martin F. Bachmann, Monique Vogel

Publikováno v: Vaccines
Volume 9
Issue 4
Vaccines, Vol 9, Iss 403, p 403 (2021)
Liu, Xuelan; Chang, Xinyue; Rothen, Dominik; Derveni, Mariliza; Krenger, Pascal; Roongta, Salony; Wright, Edward; Vogel, Monique; Tars, Kaspars; Mohsen, Mona O.; Bachmann, Martin F. (2021). AP205 VLPs Based on Dimerized Capsid Proteins Accommodate RBM Domain of SARS-CoV-2 and Serve as an Attractive Vaccine Candidate. Vaccines, 9(4) MDPI 10.3390/vaccines9040403

COVID-19 is a novel disease caused by SARS-CoV-2 which has conquered the world rapidly resulting in a pandemic that massively impacts our health, social activities, and economy. It is likely that vaccination is the only way to form “herd immunity�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa73c85c571d511a4a5c67df24b3e52
https://pubmed.ncbi.nlm.nih.gov/33921677

Dynamic 23S rRNA modification ho5C2501 benefits Escherichia coli under oxidative stress.

Autor: Fasnacht, Michel, Gallo, Stefano, Sharma, Puneet, Himmelstoß, Maximilian, Limbach, Patrick A, Willi, Jessica, Polacek, Norbert

Publikováno v: Nucleic Acids Research; 1/11/2022, Vol. 50 Issue 1, p473-489, 17p

Low‐affinity but high‐avidity interactions may offer an explanation for IgE‐mediated allergen cross‐reactivity.

Autor: Chang, Xinyue, Zha, Lisha, Wallimann, Alexandra, Mohsen, Mona O., Krenger, Pascal, Liu, Xuelan, Vogel, Monique, Bachmann, Martin F.

Publikováno v: Allergy; Aug2021, Vol. 76 Issue 8, p2565-2574, 10p