Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Pascal Kienlen-Campard"'
Autor:
Emilien Boyer, Louise Deltenre, Marion Dourte, Lise Colmant, Esther Paître, Kristel Sleegers, Nuria Suelves, Bernard Hanseeuw, Pascal Kienlen-Campard
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Amyloid-β (Aβ) and tau are brain hallmarks of Alzheimer’s disease (AD), also present in blood as soluble biomarkers or encapsulated in extracellular vesicles (EVs). Our goal was to assess how soluble plasma biomarkers of AD pa
Externí odkaz:
https://doaj.org/article/e06a306f8fb548a7be1621092c910e71
Autor:
Nathalie Kyalu Ngoie Zola, Clémence Balty, Sébastien Pyr dit Ruys, Axelle A. T. Vanparys, Nicolas D. G. Huyghe, Gaëtan Herinckx, Manuel Johanns, Emilien Boyer, Pascal Kienlen-Campard, Mark H. Rider, Didier Vertommen, Bernard J. Hanseeuw
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The tau isoforms observed in post mortem human brain aggregates is used to classify tauopathies. However, distinguishing tauopathies ante mortem remai
Externí odkaz:
https://doaj.org/article/4e8b82b43d3a464a834a3b43efbae384
Autor:
Nuria Suelves, Shirine Saleki, Tasha Ibrahim, Debora Palomares, Sebastiaan Moonen, Marta J. Koper, Céline Vrancx, Devkee M. Vadukul, Nicolas Papadopoulos, Nikenza Viceconte, Eloïse Claude, Rik Vandenberghe, Christine A. F. von Arnim, Stefan N. Constantinescu, Dietmar Rudolf Thal, Anabelle Decottignies, Pascal Kienlen-Campard
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-26 (2023)
Abstract Aging is the main risk factor for Alzheimer’s disease (AD) and other neurodegenerative pathologies, but the molecular and cellular changes underlying pathological aging of the nervous system are poorly understood. AD pathology seems to cor
Externí odkaz:
https://doaj.org/article/5f4fdaf58fee4378a6e15e3c44d2238d
Autor:
Lise Colmant, Emilien Boyer, Thomas Gerard, Kristel Sleegers, Renaud Lhommel, Adrian Ivanoiu, Philippe Lefèvre, Pascal Kienlen-Campard, Bernard Hanseeuw
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1173 (2024)
Alzheimer’s disease (AD) is characterized by amyloid beta (Aβ) plaques and hyperphosphorylated tau in the brain. Aβ plaques precede cognitive impairments and can be detected through amyloid-positron emission tomography (PET) or in cerebrospinal f
Externí odkaz:
https://doaj.org/article/84ac648d4ab4470999642a9997b16bea
Autor:
Anna Kreis, Jana Desloovere, Nuria Suelves, Nathalie Pierrot, Xavier Yerna, Farah Issa, Olivier Schakman, Roberta Gualdani, Marie de Clippele, Nicolas Tajeddine, Pascal Kienlen-Campard, Robrecht Raedt, Jean-Noël Octave, Philippe Gailly
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The function of the amyloid precursor protein (APP) is not fully understood, but its cleavage product amyloid beta (Aβ) together with neurofibrillary tangles constitute the hallmarks of Alzheimer’s disease (AD). Yet, imbalance of excitato
Externí odkaz:
https://doaj.org/article/8573bf1d0f514383a0caa67d43212752
Autor:
Devkee M. Vadukul, Céline Vrancx, Pierre Burguet, Sabrina Contino, Nuria Suelves, Louise C. Serpell, Loïc Quinton, Pascal Kienlen-Campard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract A key hallmark of Alzheimer’s disease is the extracellular deposition of amyloid plaques composed primarily of the amyloidogenic amyloid-β (Aβ) peptide. The Aβ peptide is a product of sequential cleavage of the Amyloid Precursor Protein
Externí odkaz:
https://doaj.org/article/cffde72cfd7a458c9a29c038453f9d37
Autor:
Nicolas Papadopoulos, Nuria Suelves, Florian Perrin, Devkee M. Vadukul, Céline Vrancx, Stefan N. Constantinescu, Pascal Kienlen-Campard
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2753 (2022)
Most neurodegenerative diseases have the characteristics of protein folding disorders, i.e., they cause lesions to appear in vulnerable regions of the nervous system, corresponding to protein aggregates that progressively spread through the neuronal
Externí odkaz:
https://doaj.org/article/0eaccee654984de88c7b6d0588f1e379
Autor:
Florian Perrin, Nicolas Papadopoulos, Nuria Suelves, Rémi Opsomer, Devkee M. Vadukul, Céline Vrancx, Steven O. Smith, Didier Vertommen, Pascal Kienlen-Campard, Stefan N. Constantinescu
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102057- (2021)
Externí odkaz:
https://doaj.org/article/f665fef4c70b4f3dab58560ad815f4ab
Autor:
Sabrina Contino, Nuria Suelves, Céline Vrancx, Devkee M. Vadukul, Valery L. Payen, Serena Stanga, Luc Bertrand, Pascal Kienlen-Campard
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
Presenilin 1 (PS1) and Presenilin 2 (PS2) are predominantly known as the catalytic subunits of the γ-secretase complex that generates the amyloid-β (Aβ) peptide, the major constituent of the senile plaques found in the brain of Alzheimer's disease
Externí odkaz:
https://doaj.org/article/b607f326c9de489090109092167bf221
Autor:
Florian Perrin, Nicolas Papadopoulos, Nuria Suelves, Rémi Opsomer, Devkee M. Vadukul, Céline Vrancx, Steven O. Smith, Didier Vertommen, Pascal Kienlen-Campard, Stefan N. Constantinescu
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101887- (2020)
Summary: Amyloid precursor protein (APP) cleavage by the β-secretase produces the C99 transmembrane (TM) protein, which contains three dimerization-inducing Gly-x-x-x-Gly motifs. We demonstrate that dimeric C99 TM orientations regulate the precise c
Externí odkaz:
https://doaj.org/article/0dd44fb254d34538a6340aed44bc05be