Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Pascal Kessler"'
Autor:
Justine Hadjerci, Anne Billet, Pascal Kessler, Gilles Mourier, Marine Ghazarian, Anthony Gonzalez, Christian Wunder, Nesrine Mabrouk, Eric Tartour, Denis Servent, Ludger Johannes
Publikováno v:
Cells, Vol 12, Iss 9, p 1291 (2023)
Many molecular targets for cancer therapy are located in the cytosol. Therapeutic macromolecules are generally not able to spontaneously translocate across membranes to reach these cytosolic targets. Therefore a strong need exists for tools that enha
Externí odkaz:
https://doaj.org/article/7e3ce7fe20a4467496df4c2ec0b3aca2
Autor:
Jelena Scekic-Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa Kan, Salim Megat, Pierre De Rossi, Stéphane Dieterlé, Raphaelle Cassel, Marguerite Jamet, Pascal Kessler, Diana Wiesner, Laura Tzeplaeff, Valérie Demais, Sonu Sahadevan, Katharina M. Hembach, Hans-Peter Muller, Gina Picchiarelli, Nibha Mishra, Stefano Antonucci, Sylvie Dirrig-Grosch, Jan Kassubek, Volker Rasche, Albert Ludolph, Anne-Laurence Boutillier, Francesco Roselli, Magdalini Polymenidou, Clotilde Lagier-Tourenne, Sabine Liebscher, Luc Dupuis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Mutations in the RNA binding protein FUS are associated with ALS. Here the authors show that in FUS knock-in mice there is a progressive increase in neuronal activity in the frontal cortex which is associated with altered synaptic gene expression.
Externí odkaz:
https://doaj.org/article/81d53965ba1c4f5cbe4fa11bc13113fd
Autor:
Anne-Cécile Van Baelen, Xavier Iturrioz, Marion Chaigneau, Pascal Kessler, Catherine Llorens-Cortes, Denis Servent, Nicolas Gilles, Philippe Robin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2330 (2023)
The renin-angiotensin system (RAS) is one of the main regulatory systems of cardiovascular homeostasis. It is mainly composed of angiotensin-converting enzyme (ACE) and angiotensin II receptors AT1 and AT2. ACE and AT1 are targets of choice for the t
Externí odkaz:
https://doaj.org/article/f36726fc73e648369fb9448908d3a905
Autor:
Anne-Cécile Van Baelen, Philippe Robin, Pascal Kessler, Arhamatoulaye Maïga, Nicolas Gilles, Denis Servent
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Peptide toxins from venoms have undergone a long evolutionary process allowing host defense or prey capture and making them highly selective and potent for their target. This has resulted in the emergence of a large panel of toxins from a wide divers
Externí odkaz:
https://doaj.org/article/5dbe36a627e94a97bf66bffda05673ae
Autor:
Alice Karam, Lars Tebbe, Chantal Weber, Nadia Messaddeq, Laurette Morlé, Pascal Kessler, Uwe Wolfrum, Yvon Trottier
Publikováno v:
Neurobiology of Disease, Vol 80, Iss , Pp 15-28 (2015)
Huntington's disease (HD) is a neurodegenerative disorder caused by the toxic expansion of polyglutamine in the Huntingtin (HTT) protein. The pathomechanism is complex and not fully understood. Increasing evidence indicates that the loss of normal pr
Externí odkaz:
https://doaj.org/article/5ea3b120b8c14d8da8a1153622d2761e
Autor:
Helena Moreira-Tabaka, Jean Peluso, Jean-Luc Vonesch, Didier Hentsch, Pascal Kessler, Jean-Marie Reimund, Serge Dumont, Christian D Muller
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34184 (2012)
Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine today identified as a key mediator of several chronic inflammatory diseases. TNF-α, initially synthesized as a membrane-anchored precursor (pro-TNF-α), is processed by proteolytic
Externí odkaz:
https://doaj.org/article/f35f80021e1e40aa821afba47761124d
Autor:
Nathalie Dereuddre-Bosquet, Laurence Morellato-Castillo, Joachim Brouwers, Patrick Augustijns, Kawthar Bouchemal, Gilles Ponchel, Oscar H P Ramos, Carolina Herrera, Martha Stefanidou, Robin Shattock, Leo Heyndrickx, Guido Vanham, Pascal Kessler, Roger Le Grand, Loïc Martin
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12, p e1003071 (2012)
In complement to an effective vaccine, development of potent anti-HIV microbicides remains an important priority. We have previously shown that the miniCD4 M48U1, a functional mimetic of sCD4 presented on a 27 amino-acid stable scaffold, inhibits a b
Externí odkaz:
https://doaj.org/article/0589cd679b414475b3cbd112e8baf239
Autor:
Antu K Dey, Brian Burke, Yide Sun, Klara Sirokman, Avishek Nandi, Karin Hartog, Ying Lian, Anthony R Geonnotti, David Montefiori, Michael Franti, Grégoire Martin, Andrea Carfi, Pascal Kessler, Loïc Martin, Indresh K Srivastava, Susan W Barnett
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30233 (2012)
The identification of HIV-1 envelope glycoprotein (Env) structures that can generate broadly neutralizing antibodies (BNAbs) is pivotal to the development of a successful vaccine against HIV-1 aimed at eliciting effective humoral immune responses. To
Externí odkaz:
https://doaj.org/article/8de4cde9f4c94164b95e696ae0582869
Autor:
Coralie Spiegelhalter, Valérie Tosch, Didier Hentsch, Marc Koch, Pascal Kessler, Yannick Schwab, Jocelyn Laporte
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9014 (2010)
BACKGROUND: In cell biology, the study of proteins and organelles requires the combination of different imaging approaches, from live recordings with light microscopy (LM) to electron microscopy (EM). METHODOLOGY: To correlate dynamic events in adher
Externí odkaz:
https://doaj.org/article/d2afcbf059564ac1adbc2dee50a68090
Autor:
Màté A Demény, Evi Soutoglou, Zita Nagy, Elisabeth Scheer, Agnes Jànoshàzi, Magalie Richardot, Manuela Argentini, Pascal Kessler, Laszlo Tora
Publikováno v:
PLoS ONE, Vol 2, Iss 3, p e316 (2007)
TFIID plays a role in nucleating RNA polymerase II preinitiation complex assembly on protein-coding genes. TFIID is a multisubunit complex comprised of the TATA box binding protein (TBP) and 14 TBP-associated factors (TAFs). Another class of multipro
Externí odkaz:
https://doaj.org/article/eafceda573f64921a4c463284e00d77e