Evaluation of the impact of the cancer therapy everolimus on the central nervous system in mice.

Autor: Martine Dubois, Vadim Le Joncour, Marie-Christine Tonon, Youssef Anouar, François Proust, Fabrice Morin, Pierrick Gandolfo, Florence Joly, Pascal Hilber, Hélène Castel

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113533 (2014)

Cancer and treatments may induce cognitive impairments in cancer patients, and the causal link between chemotherapy and cognitive dysfunctions was recently validated in animal models. New cancer targeted therapies have become widely used, and their i

Externí odkaz: https://doaj.org/article/3bef6c5b9e1346d3a919fc937d14f69a

The Role of the Cerebellar and Vestibular Networks in Anxiety Disorders and Depression: the Internal Model Hypothesis

Autor: Pascal Hilber

Publikováno v: Cerebellum (London, England). 21(5)

Clinical data and animal studies confirmed that the cerebellum and the vestibular system are involved in emotions. Nowadays, no real consensus has really emerged to explain the clinical symptoms in humans and behavioral deficits in the animal models.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e008aea5c0530a42c27e2e90827d99a
https://pubmed.ncbi.nlm.nih.gov/35414040

Familiarization effects on the behavioral disinhibition of the cerebellar Lurcher mutant mice: use of the innovative Dual Maze

Autor: Pascal Hilber, T. Lorivel, Jan Cendelin

Publikováno v: Behavioural Brain Research
Behavioural Brain Research, Elsevier, 2021, 398, pp.112972-. ⟨10.1016/j.bbr.2020.112972⟩
Behavioural Brain Research, Elsevier, 2021, 398, pp.112972. ⟨10.1016/j.bbr.2020.112972⟩

Anxiety-related behaviors in mice are often assessed over short periods starting immediately after introducing the animals in a dedicated apparatus. In these usual conditions (5−10 min periods), the cerebellar Lurcher mutants showed disinhibited be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87711cf4f4be6f39ddb56a76c0e918bb
https://hal.archives-ouvertes.fr/hal-03492693

Cooperation of the vestibular and cerebellar networks in anxiety disorders and depression

Autor: Anne Le Gall, Marie-Laure Machado, Stephane Besnard, Jan Cendelin, Jan Tuma, Pascal Hilber

Publikováno v: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2019, 89, pp.310-321. ⟨10.1016/j.pnpbp.2018.10.004⟩

International audience; The discipline of affective neuroscience is concerned with the neural bases of emotion and mood. The past decades have witnessed an explosion of research in affective neuroscience, increasing our knowledge of the brain areas i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42dfd1f752d5173938af4439b1e97ab
https://pubmed.ncbi.nlm.nih.gov/30292730

Impaired spatial performance in cerebellar-deficient Lurcher mice is not associated with their abnormal stress response

Autor: Jan Cendelin, Yaroslav Kolinko, Jan Tuma, Pascal Hilber, Dana Jelinkova

Publikováno v: Neurobiology of Learning and Memory
Neurobiology of Learning and Memory, Elsevier, 2017, 140, pp.62-70. ⟨10.1016/j.nlm.2017.02.009⟩

International audience; Both humans and laboratory animals suffering from cerebellar lesions exhibit cognitive as well as many emotional and behavioral abnormalities. These latter have been already observed in the cerebellar mutant mice currently use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a98329dc5ffc805039c8bd67905eb31
https://pubmed.ncbi.nlm.nih.gov/28213063