Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Pascal H G, Duijf"'
Autor:
Parastoo Shahrouzi, Youness Azimzade, Wioletta Brankiewicz-Kopcinska, Sugandha Bhatia, David Kunke, Derek Richard, Xavier Tekpli, Vessela N. Kristensen, Pascal H. G. Duijf
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-19 (2024)
Abstract Breast cancer (BCa) is a major global health challenge. The BCa genome often carries extensive somatic copy number alterations (CNAs), including gains/amplifications and losses/deletions. These CNAs significantly affect tumor development, dr
Externí odkaz:
https://doaj.org/article/7e2f096c8a0445e396e26529cad85b30
Autor:
Jaikrishna Balakittnen, Chameera Ekanayake Weeramange, Daniel F. Wallace, Pascal H. G. Duijf, Alexandre S. Cristino, Gunter Hartel, Roberto A. Barrero, Touraj Taheri, Liz Kenny, Sarju Vasani, Martin Batstone, Omar Breik, Chamindie Punyadeera
Publikováno v:
International Journal of Oral Science, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers for the early detection of OC. This study aims to discover, develop, and valid
Externí odkaz:
https://doaj.org/article/94699367a2c44a619577d6a67c6cf402
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-18 (2023)
Abstract The Eyes Absent (EYA) family of proteins is an atypical group of four dual-functioning protein phosphatases (PP), which have been linked to many vital cellular processes and organogenesis pathways. The four family members of this PP family p
Externí odkaz:
https://doaj.org/article/84a501a5d1624c18945c54c7315e35a6
Autor:
Xiaomin Huang, Pascal H. G. Duijf, Sharath Sriram, Ganganath Perera, Sarju Vasani, Lizbeth Kenny, Paul Leo, Chamindie Punyadeera
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-19 (2023)
Abstract Head and Neck cancers (HNC) are a heterogeneous group of upper aero-digestive tract cancer and account for 931,922 new cases and 467,125 deaths worldwide. About 90% of these cancers are of squamous cell origin (HNSCC). HNSCC is associated wi
Externí odkaz:
https://doaj.org/article/ae689b76ae6548b3a1b6d69ed4dadca2
Autor:
Behnam Rashidieh, Amanda Louise Bain, Simon Manuel Tria, Sowmya Sharma, Cameron Allan Stewart, Jacinta Ley Simmons, Pirjo M. Apaja, Pascal H. G. Duijf, John Finnie, Kum Kum Khanna
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-19 (2023)
Abstract Background αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers. Previous studies using human cancer cell lines and human xenograft
Externí odkaz:
https://doaj.org/article/e79655148af34996b2fadab1d06fecb9
Autor:
Madushan Fernando, Pascal H. G. Duijf, Martina Proctor, Alexander J. Stevenson, Anna Ehmann, Shivam Vora, Dubravka Skalamera, Mark Adams, Brian Gabrielli
Publikováno v:
Oncogenesis, Vol 10, Iss 5, Pp 1-11 (2021)
Abstract Defective DNA repair is being demonstrated to be a useful target in cancer treatment. Currently, defective repair is identified by specific gene mutations, however defective repair is a common feature of cancers without these mutations. DNA
Externí odkaz:
https://doaj.org/article/1232e95c12aa4baf83e1909df39172e3
Autor:
Katrina Kildey, Neha S. Gandhi, Katherine B. Sahin, Esha T. Shah, Eric Boittier, Pascal H. G. Duijf, Christopher Molloy, Joshua T. Burgess, Sam Beard, Emma Bolderson, Amila Suraweera, Derek J. Richard, Kenneth J. O’Byrne, Mark N. Adams
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA
Externí odkaz:
https://doaj.org/article/1fca8dd3265e4aecb2ae8d295b050bfa
Autor:
Ankit Shukla, Thu H. M. Nguyen, Sarat B. Moka, Jonathan J. Ellis, John P. Grady, Harald Oey, Alexandre S. Cristino, Kum Kum Khanna, Dirk P. Kroese, Lutz Krause, Eloise Dray, J. Lynn Fink, Pascal H. G. Duijf
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Chromosome arm-level aneuploidies (CAAs) are frequently observed in cancer. Here, the authors analyse CAA landscapes across different tumour types, relating these chromosome arm gains and losses to tumour evolution, metastasis, patient survival and r
Externí odkaz:
https://doaj.org/article/0e49d0a39fa34863b24fe89eadb7f3d8
Autor:
Afshin Derakhshani, Darya Javadrashid, Nima Hemmat, Antoine Dufour, Antonio Giovanni Solimando, Mahdi Abdoli Shadbad, Pascal H. G. Duijf, Oronzo Brunetti, Nicola Silvestris, Behzad Baradaran
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Patients with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, are at higher risk to develop colorectal cancer (CRC). However, the underlying mechanisms of this predisposition remain elusive. We performed in-depth
Externí odkaz:
https://doaj.org/article/e9676acaa7964509bafdfa0d22b8562c
Autor:
Elham Safarzadeh, Ali Mohammadi, Behzad Mansoori, Pascal H. G. Duijf, Shahryar Hashemzadeh, Vahid Khaze, Tohid Kazemi, Afshin Derakhshani, Nicola Silvestris, Behzad Baradaran
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Cancer cells escape immune destruction. From this perspective, myeloid-derived suppressor cells (MDSCs), which are immunosuppressive in various cancers including breast cancer (BC), are significant. However, the precise mechanisms are unknown. We iso
Externí odkaz:
https://doaj.org/article/9f5255d631454a24be6ecf22dc49afc5