Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Pascal Grondin"'
Autor:
Philippe Karoyan, Vincent Vieillard, Luis Gómez-Morales, Estelle Odile, Amélie Guihot, Charles-Edouard Luyt, Alexis Denis, Pascal Grondin, Olivier Lequin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Karoyan et al. present a method to inhibit SARS-CoV-2 by means of a peptide-mimic approach. They design a series of peptides mimicking the N-terminal helix of hACE2 protein and their best peptide-mimic blocks SARS-CoV-2 human pulmonary cell infection
Externí odkaz:
https://doaj.org/article/ed692f48c5844ca4b8d6abdcdfbbe19b
Autor:
Jean-Marie Brusq, Nicolas Ancellin, Pascal Grondin, Raphaelle Guillard, Sandrine Martin, Yannick Saintillan, Marc Issandou
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 6, Pp 1281-1288 (2006)
The alkaloid drug berberine (BBR) was recently described to decrease plasma cholesterol and triglycerides (TGs) in hypercholesterolemic patients by increasing expression of the hepatic low density lipoprotein receptor (LDLR). Using HepG2 human hepato
Externí odkaz:
https://doaj.org/article/0365268ae49845cba0188a5a5c29f6eb
Publikováno v:
Journal of Transition Metal Complexes. 6:1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6da9190da5190766045aa6b4693ad9df
https://doi.org/10.32371/jtmc/246150
https://doi.org/10.32371/jtmc/246150
Autor:
Elodie Pramil, Olivier Lequin, Thomas Denèfle, Pascal Grondin, Ana Carolina Martínez-Torres, H. Merle-Beral, Estelle Odile, Fabrice Viviani, Luis Gómez-Morales, Santos A. Susin, Mikail D. Levasseur, Linda Herbi, Philippe Karoyan, Eva Lardé, Yann Lamotte, Nicolas Ancellin, Kenny Herry, Clara Newton
Publikováno v:
Journal of Medicinal Chemistry. 62:7656-7668
In order to optimize the potency of the first serum-stable peptide agonist of CD47 (PKHB1) in triggering regulated cell death of cancer cells, we designed a maturation process aimed to mimic the trimeric structure of the thrombospondin-1/CD47 binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e95163835ac5bfa2e82ae0ed04fe81
https://doi.org/10.1021/acs.jmedchem.9b00024
https://doi.org/10.1021/acs.jmedchem.9b00024
Autor:
Stéphane Sautet, Emilie Jigorel, Nicolas Faucher, Jamel Meslamani, Lara Kathryn Leister, Pascal Grondin, Julie A. Cox, Bryan W. King, Pamela Nassau, Gemma Victoria White, Brad J. Geddes, Alain Claude-Marie Daugan, Helen H. Sun, Michael T. Ouellette, Pauline Lamoureux, Elizabeth J. Rivera, Scott B. Berger, James H. Thorpe, Philip A. Harris, J. Mosley, Susan E. Hutchinson, Frédéric Donche, John Bertin, Sandra J. Hoffman, Natalie Wellaway, Patrick M. Eidam, Paris Ward, Florent Potvain, Clark A. Sehon, Sebastien Andre Campos, Robert W. Marquis, Peter J. Gough, Mukesh K. Mahajan, Veronique Beneton, Jae U. Jeong, Michelle C. Schaeffer, John D. Lich, Allison M. Beal, Rakesh Nagilla, James Michael Woolven, Bonnie L. Hoffman, Anderson Niall Andrew, Marie-Hélène Fouchet, Deepak Bandyopadhyay, Carol A. Capriotti, Rachel D. Totoritis, Joshua N. Finger, Kishore K. Pasikanti, David D. Wisnoski, Sze-Ling Ng, Nino Campobasso, Nicolas George, Michael Reilly
Publikováno v:
Journal of Medicinal Chemistry. 62:5096-5110
RIP1 kinase regulates necroptosis and inflammation and may play an important role in contributing to a variety of human pathologies, including inflammatory and neurological diseases. Currently, RIP1 kinase inhibitors have advanced into early clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ff65b82b2e1feff6acc28b9dcac4dc
https://doi.org/10.1021/acs.jmedchem.9b00318
https://doi.org/10.1021/acs.jmedchem.9b00318
Autor:
Alexis Denis, Olivier Lequin, Amélie Guihot, Pascal Grondin, Philippe Karoyan, Luis Gómez-Morales, Charles-Edouard Luyt, Vincent Vieillard, Estelle Odile
Publikováno v:
Communications Biology
Communications Biology, 2021, 4 (1), pp.197. ⟨10.1038/s42003-021-01736-8⟩
Communications Biology, Nature Publishing Group, 2021, 4, ⟨10.1038/s42003-021-01736-8⟩
Communications Biology, Nature Publishing Group, 2021, 4 (1), ⟨10.1038/s42003-021-01736-8⟩
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Communications Biology, 2021, 4 (1), pp.197. ⟨10.1038/s42003-021-01736-8⟩
Communications Biology, Nature Publishing Group, 2021, 4, ⟨10.1038/s42003-021-01736-8⟩
Communications Biology, Nature Publishing Group, 2021, 4 (1), ⟨10.1038/s42003-021-01736-8⟩
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
In light of the recent accumulated knowledge on SARS-CoV-2 and its mode of human cells invasion, the binding of viral spike glycoprotein to human Angiotensin Converting Enzyme 2 (hACE2) receptor plays a central role in cell entry. We designed a serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f663d504d8ddf9493bf5978b00772b
https://hal.sorbonne-universite.fr/hal-03141346/file/s42003-021-01736-8.pdf
https://hal.sorbonne-universite.fr/hal-03141346/file/s42003-021-01736-8.pdf
Autor:
Vincent Vieillard, Olivier Lequin, Charles-Edouard Luyt, Alexis Denis, Amélie Guihot, Philippe Karoyan, Pascal Grondin, Estelle Odile, Luis Gómez-Morales
In the light of the recent accumulated knowledge on SARS-CoV-2 and its mode of human cells invasion, the binding of viral spike glycoprotein to human Angiotensin Converting Enzyme 2 (hACE2) receptor plays a central role in cell entry. We designed a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f47ad8cbc1ef47955860df2695c9b10d
https://doi.org/10.1101/2020.08.24.264077
https://doi.org/10.1101/2020.08.24.264077
Autor:
Yann Dudit, Zehong Wan, Don O. Somers, Yingxia Sang, Vipulkumar Kantibhai Patel, Pascal Grondin, Joseph E. Coyle, Veronique Beneton, Rachel McMenamin, Lee William Page, Philip J. Day, Alison Jo-Anne Woolford, Lionel Trottet, Valerio Berdini, Florent Potvain, Sharna J. Rich, Christopher William Murray, Pascal Huet, Lydia Y. W. Lee, Xiaomin Zhang, Eric S. Manas
Publikováno v:
Journal of Medicinal Chemistry. 59:10738-10749
Lp-PLA2 has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype that interacts with the active site of Lp-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e0ae2687867d1f42424c9a09ec700b8
https://doi.org/10.1021/acs.jmedchem.6b01427
https://doi.org/10.1021/acs.jmedchem.6b01427
Autor:
Kirsten V. Smith, Joseph E. Pero, Ralph A. Rivero, Donald O. Somers, Vipulkumar Kantibhai Patel, Agnes C. L. Martin, Rachel McMenamin, Sridhar Aravapalli, Finn P. Holding, Eric S. Manas, Lionel Trottet, Alison Jo-Anne Woolford, Neipp Christopher E, Lydia Y. W. Lee, Ranganadh Velagaleti, Sharna J. Rich, Ren Xie, Peng Li, Glyn Williams, Andrew M. Dodson, Brent W. Mccleland, Lee William Page, Joseph P. Marino, Pascal Grondin, Florent Potvain, Joseph E. Coyle, Christopher William Murray, Philip J. Day, Valerio Berdini
Publikováno v:
Journal of Medicinal Chemistry. 59:5356-5367
Elevated levels of human lipoprotein-associated phospholipase A2 (Lp-PLA2) are associated with cardiovascular disease and dementia. A fragment screen was conducted against Lp-PLA2 in order to identify novel inhibitors. Multiple fragment hits were obs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7919286100bbcfc9e76bca6023c7c4
https://doi.org/10.1021/acs.jmedchem.6b00212
https://doi.org/10.1021/acs.jmedchem.6b00212
Autor:
Marie-Claude Viaud-Massuard, Ludovic Juen, Ambrine Sahal, Jean-François Mirjolet, Camille Martin, Ofelia Feuillâtre, Pascal Grondin, Audrey Desgranges, Audrey Bertaux, Camille Gély, Guillaume Serin, Samira Benhamouche-Trouillet, Christine B. Baltus
Publikováno v:
Cancer Research. 80:4115-4115
Introduction: The Antibody-Drug Conjugates (ADCs)-based therapy has revealed a field of perspectives by increasing the specificity and the efficacy of the anti-tumoral drug treatment. McSAF is a company focused in bio-organic and bioconjugates chemis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d666a608c4786b701813ddcb614880e1
https://doi.org/10.1158/1538-7445.am2020-4115
https://doi.org/10.1158/1538-7445.am2020-4115