Výsledky vyhledávání - "Pascal Gosselin-Badaroudine"

Akademický článek

A proton leak current through the cardiac sodium channel is linked to mixed arrhythmia and the dilated cardiomyopathy phenotype.

Autor: Pascal Gosselin-Badaroudine, Dagmar I Keller, Hai Huang, Valérie Pouliot, Aurélien Chatelier, Stefan Osswald, Marijke Brink, Mohamed Chahine

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e38331 (2012)

Cardiac Na(+) channels encoded by the SCN5A gene are essential for initiating heart beats and maintaining a regular heart rhythm. Mutations in these channels have recently been associated with atrial fibrillation, ventricular arrhythmias, conduction

Externí odkaz: https://doaj.org/article/4a1a7ab5c7f042bc826687ada97601c6

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Novel OSNR Measurement Techniques Based on Optical Spectrum Analysis and Their Application to Coherent-Detection Systems

Autor: Sorin Tibuleac, Daniel Gariepy, Pascal Gosselin-Badaroudine, Michel Leclerc, Steven Searcy, Gang He

Publikováno v: Journal of Lightwave Technology. 37:562-570

We discuss and review in-service optical-signal-to-noise-ratio measurement techniques with a focus on methods relying on optical spectrum analysis. We briefly review the optical signal-to-noise ratio (OSNR) definition and the measurement procedure em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c51414aee02d54cedb09de2e7814e31
https://doi.org/10.1109/jlt.2018.2878744

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Substitutions of the S4DIV R2 residue (R1451) in NaV1.4 lead to complex forms of paramyotonia congenita and periodic paralyses

Autor: Saïd Bendahhou, Pascal Gosselin-Badaroudine, Serena Giuliano, Savine Vicart, Mohamed Chahine, Hugo Poulin, Sophie Nicole, Damien Sternberg, Karima Habbout, Bertrand Fontaine

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2018, 8, pp.2041. ⟨10.1038/s41598-018-20468-0⟩
Scientific Reports, 2018, 8, pp.2041. ⟨10.1038/s41598-018-20468-0⟩

Mutations in NaV1.4, the skeletal muscle voltage-gated Na+ channel, underlie several skeletal muscle channelopathies. We report here the functional characterization of two substitutions targeting the R1451 residue and resulting in 3 distinct clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef7279d6e17036666d272fb8a3e31a0
http://link.springer.com/article/10.1038/s41598-018-20468-0

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Biophysical characterization of the honeybee DSC1 orthologue reveals a novel voltage-dependent Ca2+ channel subfamily: CaV4

Autor: Claude Collet, Louis Simard, Pascal Gosselin-Badaroudine, Pierre Charnet, Matthieu Rousset, Thierry Cens, Mohamed Chahine, Adrien Moreau

Publikováno v: Journal of General Physiology
Journal of General Physiology, Rockefeller University Press, 2016, 148 (2), pp.133-145. ⟨10.1085/jgp.201611614⟩

International audience; Bilaterian voltage-gated Na(+) channels (NaV) evolved from voltage-gated Ca(2+) channels (CaV). The Drosophila melanogaster Na(+) channel 1 (DSC1), which features a D-E-E-A selectivity filter sequence that is intermediate betw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e1330b7ed611abdde6aeec49eccced
https://doi.org/10.1085/jgp.201611614

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A leaky voltage sensor domain of cardiac sodium channels causes arrhythmias associated with dilated cardiomyopathy

Autor: Pascal Gosselin-Badaroudine, Adrien Moreau, Bettina Burger, Mohamed Chahine, Aurélie Mercier, Dagmar I. Keller

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Dilated cardiomyopathy (DCM) is a structural heart disease that causes dilatation of cardiac chambers and impairs cardiac contractility. The SCN5A gene encodes Nav1.5, the predominant cardiac sodium channel alpha subunit. SCN5A mutations have been id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f89adb0a6abb997ebe4eade5bc4cff
https://doi.org/10.1038/s41598-018-31772-0

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Gating pore currents, a new pathological mechanism underlying cardiac arrhythmias associated with dilated cardiomyopathy

Autor: Adrien Moreau, Pascal Gosselin-Badaroudine, Mohamed Chahine

Publikováno v: Channels

Voltage-gated ion channels (VGIC) are transmembrane proteins responsible for the generation of electrical signals in excitable cells. VGIC were first described in 1952 by Hodgkin and Huxley, (1) and have since been associated with various physiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afad7ed26048c706d8573b0f2677950
https://doi.org/10.1080/19336950.2015.1031937

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Novel In-Service OSNR Monitoring Method for Reconfigurable Coherent Networks

Autor: Sorin Tibuleac, Pascal Gosselin-Badaroudine, Steven Searcy, Gang He, Daniel Gariepy, M. Leclerc

Publikováno v: OFC

A novel in-service OSNR monitoring technique is experimentally validated on tightly filtered polarization-multiplexed signals for a range of network operating conditions and reconfigurations. The results demonstrate sufficient accuracy and robustness

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0bb23fca19a13d9dc8d7d7cb0683116
https://doi.org/10.1364/ofc.2018.w2a.4

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