Výsledky vyhledávání - "Pascal Genin"

Analysis of PIK3CA exon 9 and 20 mutations in breast cancers using PCR-HRM and PCR-ARMS: Correlation with clinicopathological criteria

Autor: Nicolas Lozano, Valentin Harter, Pascal Genin, Marie Husson, Maeva Lion, Alexandre Harlé, Jean-Louis Merlin

Publikováno v: Oncology Reports
Oncology Reports, Spandidos Publications, 2013, 29 (3), pp.1043-1052. ⟨10.3892/or.2013.2229⟩

Phosphatidylinositol-3-kinases (PI3K) are essential for cell signaling, proliferation, differentiation and survival. The catalytic subunit of PI3K, encoded by the PIK3CA oncogene, is mutated in 18-45% of breast carcinomas. These mutations, involved i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba969ca841c68eeaddac607a610df80
https://doi.org/10.3892/or.2013.2229

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Optimization of routine KRAS mutation PCR ‐based testing procedure for rational individualized first‐line‐targeted therapy selection in metastatic colorectal cancer

Autor: Marie Husson, Valentin Harter, Marie Rouyer, Alexandre Harlé, Agnès Leroux, Carole Ramacci, Anne-Sophie Chretien, Magali Meyer-Lefebvre, Jean-Louis Merlin, Pascal Genin

Publikováno v: Cancer Medicine. 2:11-20

KRAS mutation detection represents a crucial issue in metastatic colorectal cancer (mCRC). The optimization of KRAS mutation detection delay enabling rational prescription of first-line treatment in mCRC including anti-EGFR-targeted therapy requires

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6586cea06bce592365cb1b7eaf15090d
https://doi.org/10.1002/cam4.47

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Les carcinomes métaplasiques du sein : une étude morphologique et immunohistochimique

Autor: François Guillemin, E. Gauchotte, Aude Bressenot, Jean-Luc Verhaeghe, Agnès Leroux, Pascal Genin, Guillaume Gauchotte

Publikováno v: Annales de Pathologie. 31:18-27

Resume Introduction Les carcinomes metaplasiques du sein sont rares et forment un groupe heterogene de tumeurs, definies par la presence d’une differenciation epidermoide ou sarcomatoide. Patientes et methodes A partir d’une serie de 23 cas, nous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c26ee630b53cb2feb81fcf58865f08bf
https://doi.org/10.1016/j.annpat.2010.10.007

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Abstract P3-05-07: Poor prognosis early breast cancer: pathological characteristics of the Unicancer-PACS08 trial including patients treated with docetaxel or ixabepilone in adjuvant setting

Autor: M-L Quintyn-Ranty, M. Campone, Frédérique Penault-Llorca, P. Caveriviere, Jocelyne Jacquemier, Ghislaine Escourrou, Christel Mesleard, A-L Martin, V Maisongrosse, Magali Lacroix-Triki, Eliane Mery, C Bor, Jérôme Lemonnier, J. Reyre, Thomas Filleron, Paul Delrée, Pascal Genin

Publikováno v: Cancer Research. 72:P3-05

Background: The PACS08 trial aimed to compare adjuvant FEC100-Docetaxel regimen to FEC100-Ixabepilone (Ixa) in poor prognosis early breast cancer (BC). The study population included BC patients presenting with triple-negative (TN) [i.e. estrogen rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e02ef95e5bbb78dbe7439b5761713ae0
https://doi.org/10.1158/0008-5472.sabcs12-p3-05-07

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HER2 status in patients with breast carcinoma is not modified selectively by preoperative chemotherapy and is stable during the metastatic process

Autor: Pierre Pouillart, Brigitte Sigal-Zafrani, M. Jouve, Philippe Beuzeboc, Pascal Genin, Martial Caly, Anne Vincent-Salomon, Xavier Sastre-Garau, Paul Fréneaux

Publikováno v: Cancer. 94:2169-2173

BACKGROUND The objective of this study was to determine whether HER2 expression levels in breast carcinomas were modified by chemotherapy or during the metastatic process. METHODS HER2 expression was analyzed on sequential tissue specimens taken from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ca774e906199268e1cea2d5da22fb5e9
https://doi.org/10.1002/cncr.10456

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2014 update of the GEFPICS' recommendations for HER2 status determination in breast cancers in France

Publikováno v: Annales de pathologie. 34(5)

International guidelines on HER2 determination in breast cancer have just been updated by the American Society of Clinical Oncology (ASCO) and College of American Pathologists (CAP), on the basis of more than ten-year practice, results of clinical tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb3e1436af38ea715edb5c901d58f830
https://pubmed.ncbi.nlm.nih.gov/25439988

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[Pre-analytical stage for biomarker assessment in breast cancer: 2014 update of the GEFPICS' guidelines in France]

Publikováno v: Annales de pathologie. 34(5)

Biomarker assessment of breast cancer tumor samples is part of the routine workflow of pathology laboratories. International guidelines have recently been updated, with special regards to the pre-analytical steps that are critical for the quality of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d498832084c20fd656fff490a5e8d44d
https://pubmed.ncbi.nlm.nih.gov/25439989

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Recommandations du GEFPICS concernant la phase pré-analytique pour l’évaluation de HER2 et des récepteurs hormonaux dans le cancer du sein : mise à jour 2014

Publikováno v: Annales de Pathologie
Annales de Pathologie, Elsevier Masson, 2014, 34 (5), pp.366-372. ⟨10.1016/j.annpat.2014.08.017⟩

International audience; Les tumeurs fixées et incluses en paraffine sont quotidiennement utilisées pour l’évaluation des biomarqueurs nécessaires au traitement des patientes atteintes d’un cancer du sein invasif. Les nouvelles recommandations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c86030eb5d4b9dce940c1c3ac0cbd2c
https://hal.univ-angers.fr/hal-03389744

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Using one-step nucleic acid amplification (OSNA) for intraoperative detection of lymph node metastasis in breast cancer patients avoids second surgery and accelerates initiation of adjuvant therapy

Autor: Anne-Sophie Chrétien, Ouarda Kenouchi, Pascal Genin, Philippe Rauch, Agnès Leroux, Frédéric Marchal, Jean-Louis Merlin, Sophie Klingler

Publikováno v: Annals of Oncology
Annals of Oncology, Elsevier, 2013, 24 (9), pp.2305-2309. ⟨10.1093/annonc/mdt160⟩

International audience; BACKGROUND: Sentinel lymph node (SLN) analysis is conventionally analyzed using immunohistochemistry and in the case of SLN involvement, justifies a second surgery for axillary lymph node (ALN) resection, thus delaying the ini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db7e52937f2076ac46db9cd96aee4a6
https://hal.archives-ouvertes.fr/hal-00823925

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Comparison of COBAS 4800 KRAS, TaqMan PCR and high resolution melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas

Autor: Pascal Genin, Valentin Harter, Alexandre Harlé, Jean-Louis Merlin, Agnès Leroux, Marie Rouyer, Benoit Busser

Publikováno v: Virchows Archiv
Virchows Archiv, Springer Verlag, 2013, 462 (3), pp.329-335. ⟨10.1007/s00428-013-1380-x⟩

International audience; Many studies documented the influence of KRAS mutation status on the response of patients with metastatic colorectal cancer (mCRC) to anti-EGFR monoclonal antibodies. The COBAS 4800 KRAS is an assay using real time PCR and Taq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98df9f15e6b4139d4702c5284b1b27a0
https://pubmed.ncbi.nlm.nih.gov/23400679

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