Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Pascal Fossat"'
Publikováno v:
Cells, Vol 13, Iss 12, p 997 (2024)
Chronic pain is a pathological state defined as daily pain sensation over three consecutive months. It affects up to 30% of the general population. Although significant research efforts have been made in the past 30 years, only a few and relatively l
Externí odkaz:
https://doaj.org/article/dfab24c0d09c41cabf0dc7057a0bd359
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
Autor:
Arnaud Landra-Willm, Ameya Karapurkar, Alexia Duveau, Anne Amandine Chassot, Lucille Esnault, Gerard Callejo, Marion Bied, Stephanie Häfner, Florian Lesage, Brigitte Wdziekonski, Anne Baron, Pascal Fossat, Laurent Marsollier, Xavier Gasull, Eric Boué-Grabot, Michael A. Kienzler, Guillaume Sandoz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Research on pain often relies on animals, and there is always a need for more precise and more ethical tools. Here, authors present a light-activatable molecule that induces pain in freely moving animal models in a reversible, non-invasive, and spati
Externí odkaz:
https://doaj.org/article/4a75ffe8336b4cd5967121ece0b3ada7
Autor:
Damien Gilabert, Alexia Duveau, Sara Carracedo, Nathalie Linck, Adeline Langla, Rieko Muramatsu, Friedrich Koch-Nolte, François Rassendren, Thomas Grutter, Pascal Fossat, Eric Boué-Grabot, Lauriane Ulmann
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108110- (2023)
Summary: In neuropathic pain, recent evidence has highlighted a sex-dependent role of the P2X4 receptor in spinal microglia in the development of tactile allodynia following nerve injury. Here, using internalization-defective P2X4mCherryIN knockin mi
Externí odkaz:
https://doaj.org/article/fa9120bd2cce452d9255ae5d3ab437c4
Publikováno v:
Applied Sciences, Vol 13, Iss 16, p 9458 (2023)
This work addresses the dynamic modeling of a negative stiffness absorber consisting of an assembly of curved beams. Design rules are derived from the orders of magnitude of stiffness and elastic energy stored by the negative stiffness elements. Alth
Externí odkaz:
https://doaj.org/article/bc503cfdb8a44ecd822f9418428951e7
Autor:
Julien Bacqué-Cazenave, Pascal Fossat, Fadi A. Issa, Donald H. Edwards, Jean Paul Delbecque, Daniel Cattaert
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Serotonin (5-HT) is a major neuromodulator acting on the nervous system. Its various effects have been studied in vertebrates, as well as in arthropods, from the cellular and subcellular compartments up to the behavioral level, which includes the con
Externí odkaz:
https://doaj.org/article/8a4e659d6cc146958731a5bf37cba95d
Publikováno v:
PAIN Reports, Vol 3, Iss 3, p e660 (2018)
Abstract. Introduction:. Purinergic ionotropic P2X receptors (P2RX) are involved in normal and pathological pain transmission. Among them, P2X4 are expressed in dorsal root ganglion and in the spinal cord. Their activation during nerve injury or chro
Externí odkaz:
https://doaj.org/article/4a6303cf542e49e7a1b414d7503e53cf
Publikováno v:
Bio-Protocol, Vol 5, Iss 3 (2015)
Crayfish are omnivorous freshwater arthropods that naturally explore their environment during day and night, but also frequently hide under a shelter or in a hole in case of danger. They may be submitted to various stressors, including predation, soc
Externí odkaz:
https://doaj.org/article/a340b6ac4e7e4809af9f50aaaeaa923f
Autor:
Otmane Bouchatta, Franck Aby, Wahiba Sifeddine, Rabia Bouali-Benazzouz, Louison Brochoire, Houria Manouze, Pascal Fossat, Saadia Ba M’Hamed, Mohamed Bennis, Marc Landry
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(30)
Clinical evidence suggests that pain hypersensitivity develops in patients with attention-deficit/hyperactivity disorder (ADHD). However, the mechanisms and neural circuits involved in these interactions remain unknown because of the paucity of studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af657fd1d3c3fe11fdd7b40a891e18a7
https://pubmed.ncbi.nlm.nih.gov/35858441
https://pubmed.ncbi.nlm.nih.gov/35858441
Autor:
Nanci Winke, Franck Aby, Daniel Jercog, Delphine Girard, Zoé Grivet, Marc Landry, Laia Castell, Emmanuel Valjent, Stéphane Valerio, Pascal Fossat, Cyril Herry
Upon threatening situations, animals exhibit a broad range of behavioral and autonomic responses necessary for survival. Under such conditions, a crucial adaptive response is the inhibition of pain responses that would otherwise interfere with behavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43baa4d0c2897fcd19ce6161df8f92b6
https://doi.org/10.21203/rs.3.rs-1975119/v1
https://doi.org/10.21203/rs.3.rs-1975119/v1
Autor:
Franck Aby, Louis-Etienne Lorenzo, Zoé Grivet, Rabia Bouali-Benazzouz, Hugo Martin, Stéphane Valerio, Sara Whitestone, Dominique Isabel, Walid Idi, Otmane Bouchatta, Philippe De Deurwaerdere, Antoine G. Godin, Cyril Herry, Xavier Fioramonti, Marc Landry, Yves De Koninck, Pascal Fossat
Publikováno v:
Science Advances. 8
Descending control from the brain to the spinal cord shapes our pain experience, ranging from powerful analgesia to extreme sensitivity. Increasing evidence from both preclinical and clinical studies points to an imbalance toward descending facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51e07297eb045cabc044a67971586b1
https://doi.org/10.1126/sciadv.abo0689
https://doi.org/10.1126/sciadv.abo0689