Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Pascal Ezan"'
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106681- (2024)
Lenadogene nolparvovec is a gene therapy which has been developed to treat Leber hereditary optic neuropathy (LHON) caused by a point mutation in the mitochondrial NADH dehydrogenase 4 (ND4) gene. Clinical trials have demonstrated a significant impro
Externí odkaz:
https://doaj.org/article/254ba0f4562143f28a868d12e6c4e99d
Autor:
Danijela Bataveljic, Helena Pivonkova, Vidian de Concini, Betty Hébert, Pascal Ezan, Sylvain Briault, Alexis-Pierre Bemelmans, Jacques Pichon, Arnaud Menuet, Nathalie Rouach
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Fragile X syndrome (FXS) is an inherited form of intellectual disability caused by the loss of the mRNA-binding fragile X mental retardation protein (FMRP). FXS is characterized by neuronal hyperexcitability and behavioral defects, however t
Externí odkaz:
https://doaj.org/article/40827fccee0c456e9d2c8a8770f2efbe
Autor:
Josien Visser, Giampaolo Milior, Rachel Breton, Julien Moulard, Maina Garnero, Pascal Ezan, Jérôme Ribot, Nathalie Rouach
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114504- (2024)
Summary: Astroglial networks closely interact with neuronal populations, but their functional contribution to neuronal representation of sensory information remains unexplored. The superior colliculus (SC) integrates multi-sensory information by gene
Externí odkaz:
https://doaj.org/article/90bc9ac980494fa0999e47467e003c09
Autor:
Eléonore Hardy, Julien Moulard, Augustin Walter, Pascal Ezan, Alexis-Pierre Bemelmans, Franck Mouthon, Mathieu Charvériat, Nathalie Rouach, Armelle Rancillac
Publikováno v:
PLoS Biology, Vol 21, Iss 4 (2023)
Astrocytes crucially contribute to synaptic physiology and information processing. One of their key characteristics is to express high levels of connexins (Cxs), the gap junction–forming protein. Among them, Cx30 displays specific properties since
Externí odkaz:
https://doaj.org/article/4a8fa8cdc4c5421486603f8fb1f50af1
Autor:
Giselle Cheung, Danijela Bataveljic, Josien Visser, Naresh Kumar, Julien Moulard, Glenn Dallérac, Daria Mozheiko, Astrid Rollenhagen, Pascal Ezan, Cédric Mongin, Oana Chever, Alexis-Pierre Bemelmans, Joachim Lübke, Isabelle Leray, Nathalie Rouach
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The authors present a fluorescent probe that tracks glutamine in live cells. They demonstrate the capabilities of the probe by providing direct visual evidence of an activity-dependent glutamine supply from astroglial networks to presynaptic structur
Externí odkaz:
https://doaj.org/article/76d9e045d8fc48bdbc6eb629f33bd9bc
Autor:
Flora Vasile, Elena Dossi, Julien Moulard, Pascal Ezan, Laure Lecoin, Martine Cohen-Salmon, Philippe Mailly, Marc Le Bert, Isabelle Couillin, Alexis Bemelmans, Nathalie Rouach
Publikováno v:
PLoS Biology, Vol 20, Iss 12, p e3001891 (2022)
Astroglial release of molecules is thought to actively modulate neuronal activity, but the nature, release pathway, and cellular targets of these neuroactive molecules are still unclear. Pannexin 1, expressed by neurons and astrocytes, form nonselect
Externí odkaz:
https://doaj.org/article/35b803277e2a4c5fae0e9554e11ca1f2
Autor:
Giselle Cheung, Oana Chever, Astrid Rollenhagen, Nicole Quenech’du, Pascal Ezan, Joachim H. R. Lübke, Nathalie Rouach
Publikováno v:
Cells, Vol 12, Iss 8, p 1133 (2023)
Connexin 43, an astroglial gap junction protein, is enriched in perisynaptic astroglial processes and plays major roles in synaptic transmission. We have previously found that astroglial Cx43 controls synaptic glutamate levels and allows for activity
Externí odkaz:
https://doaj.org/article/43f135803c0548158f5233cbdadb09df
Autor:
Shirin Katoozi, Nadia Skauli, Soulmaz Zahl, Tushar Deshpande, Pascal Ezan, Claudia Palazzo, Christian Steinhäuser, Antonio Frigeri, Martine Cohen-Salmon, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
Publikováno v:
Cells, Vol 9, Iss 2, p 382 (2020)
The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis. While AQP4 is mainly involved in water flux a
Externí odkaz:
https://doaj.org/article/e4ca3219031e447dafbf0f937a17b8b5
Autor:
Ester Gangoso, Rocío Talaverón, Myriam Jaraíz-Rodríguez, Marta Domínguez-Prieto, Pascal Ezan, Annette Koulakoff, José M. Medina, Christian Giaume, Arantxa Tabernero
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
The non-receptor tyrosine kinase c-Src is an important mediator in several signaling pathways related to neuroinflammation. Our previous study showed that cortical injection of kainic acid (KA) promoted a transient increase in c-Src activity in react
Externí odkaz:
https://doaj.org/article/8889962443c348acbb5275c74806ce9d
Autor:
Xianjun Chen, Xiaorui Wang, Guangdan Yu, Christian Giaume, Lan Xiao, Jianqin Niu, Annette Koulakoff, Tao Li, Chenju Yi, Pascal Ezan, Xing Gao, Juan C. Sáez
Publikováno v:
Glia. 68:1201-1212
As the most abundant gap junction protein in the central nervous system (CNS), astrocytic connexin 43 (Cx43) maintains astrocyte network homeostasis, affects oligodendroglial development and participates in CNS pathologies as well as injury progressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3f658e54a5012503abfcd180e9227b
https://doi.org/10.1002/glia.23770
https://doi.org/10.1002/glia.23770