Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Pascal Espie"'
Autor:
Benjamin A Fisher, Michele Bombardieri, Hans-Ulrich Hockey, Antónia Szántó, Andrew M Wright, Athena Papas, Michael Rotte, Alexandre Avrameas, David A. Isenberg, Bettina Bannert, Pascal Espie, Cyrielle Dupuy, Steven E. Carsons, Diego Kyburz, Maximilian G. Posch, Marie-Anne Valentin, Julie Milojevic, Francesca Barone, Petra M Faerber, Simon J Bowman, Arwa M. Farag, Thomas Daikeler, Xiaohui Ren, Peter Gergely, David Floch, Wan-Fai Ng, James S. Rush, Alan Kivitz
Publikováno v:
The Lancet Rheumatology. 2:e142-e152
Summary Background Primary Sjogren's syndrome is an autoimmune disease that presents as dryness of the mouth and eyes due to impairment of the exocrine glands. To our knowledge, no systemic therapies for primary Sjogren's syndrome have shown efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e23aa3818d06c34025c01fb250d0c34
https://doi.org/10.1016/s2665-9913(19)30135-3
https://doi.org/10.1016/s2665-9913(19)30135-3
Autor:
George J. Kahaly, Craig T. Basson, Peter Gergely, Lara Frommer, Ahmed Amer, Laurence Colin, Yan-Ling He, James S. Rush, Pascal Espie, Imelda Schuhmann, Marius N. Stan
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 105:696-704
Context The CD40-CD154 co-stimulatory pathway plays an important role in the pathogenesis of Graves disease (GD) by promoting autoreactive B-cell activation. Objective Evaluate efficacy and safety of a human, blocking, nondepleting anti-CD40 monoclon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce98ec8d5567a0c42938cfad956e490f
https://doi.org/10.1210/clinem/dgz013
https://doi.org/10.1210/clinem/dgz013
Autor:
Roland Schuler, Michael Rotte, Yan-Ling He, Peter Gergely, Pascal Espie, Laurence Colin, Anita Auger, Heidi Mergentaler, Martha Hernandez‐Illas, James S. Rush, Jacinda Ristov, Julie Milojevic, Denise Sickert, Cyrielle Dupuy, Alexandre Avrameas, Edwige Chokote, Phillip Koo, Aurelie Verles, Andrea Groenewegen, Charles S. Tomek
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant SurgeonsReferences. 20(2)
Iscalimab is a fully human, CD40 pathway blocking, nondepleting monoclonal antibody being developed as an immunosuppressive agent. We describe a first-in-human, randomized, double-blind, placebo-controlled study investigating the safety, tolerability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba73cbee1406c79fa92f6a1e1a2e133
https://pubmed.ncbi.nlm.nih.gov/31647605
https://pubmed.ncbi.nlm.nih.gov/31647605
Autor:
Peter Gergely, Pascal Espie, Michele Bombardieri, Bettina Bannert, Pierre Moulin, Athena Papas, Maximilian G. Posch, Michael Rotte, Benjamin A Fisher, Simon J. Bowman, Arwa M. Farag, Amanda Nguyen, David Floch, James S. Rush, Wan-Fai Ng, Andrew M Wright, Grazyna Wieczorek, Cyrielle Dupuy, Alan Kivitz, Francesca Barone, Steven E. Carsons, Antónia Szántó, David A. Isenberg, Thomas Daikeler
Publikováno v:
Poster Presentations.
Background: Primary Sjogren’s syndrome (pSS) is a systemic progressive autoimmune disease characterised by formation of lymphoid structures and germinal centres within glandular tissue. Iscalimab (CFZ533) is a novel monoclonal antibody that potentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7432770cd61096001b6ba0352ffae775
https://doi.org/10.1136/annrheumdis-2019-eular.4277
https://doi.org/10.1136/annrheumdis-2019-eular.4277
OR19-6 A Novel Anti-CD40 Monoclonal Antibody, Iscalimab, Successfully Treats Graves’ Hyperthyroidism
Autor:
Imelda Schuhmann, Yan-Ling He, Pascal Espie, Craig T. Basson, George J. Kahaly, James S. Rush, Laurence Colin, Peter Gergely, Ahmed Amer, Marius N. Stan
Publikováno v:
Journal of the Endocrine Society
Objective: Graves’ disease (GD) is an autoimmune disorder characterized by thyrotropin receptor autoantibody (TSHR-Ab)-mediated pathology, leading to hyperthyroidism. To date there is no pharmacotherapy that addresses the underlying pathogenesis. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a53d735eba320c47e84b582845abc87
https://doi.org/10.1210/js.2019-or19-6
https://doi.org/10.1210/js.2019-or19-6
Autor:
Björn Nashan, Sandy Feng, Stuart J. Knechtle, Ute Laessing, Pascal Espie, Jan Klatt, Faouzi Saliba
Publikováno v:
Transplantation. 104:S89-S89
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f21be7a8c9230d06cc5014e03d669441
https://doi.org/10.1097/01.tp.0000698704.88369.27
https://doi.org/10.1097/01.tp.0000698704.88369.27
Autor:
Tina Rubic-Schneider, Pascal Espie, Thierry Flandre, Denise Sickert, David Andrew Shaw, James S. Rush, Peter Ulrich
Publikováno v:
Toxicological Sciences.
CFZ533 is a pathway blocking, nondepleting anti-CD40 antibody that is in clinical development for inhibition of transplant organ rejection and therapy for autoimmune diseases. A 26-week GLP toxicity study in sexually mature Cynomolgus monkeys was con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab1054f3dfd29b6b7eca6b2c23f826f
https://doi.org/10.1093/toxsci/kfy196
https://doi.org/10.1093/toxsci/kfy196
Autor:
James S. Rush, Christoph Heusser, Dorothee Müller-Ristig, Peter Ulrich, Christian Bruns, Pascal Espie, Gautier Robert, Doris Weider, Patrick Schmutz, Serge Côté, Max Warncke, Jacinda Ristov, Frank Kolbinger, Francisco Cordoba-Castro, Thierry Flandre, Denise Sickert, Barbara Greutmann, Martin A. Schneider, Mirela Dimitrova
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 18(12)
The CD40-CD154 costimulatory pathway is essential for T cell-dependent immune responses, development of humoral memory, and antigen presenting cell function. These immune functions have been implicated in the pathology of multiple autoimmune diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1861052e45b102f4cb5f6a1f9fa141
https://pubmed.ncbi.nlm.nih.gov/29665205
https://pubmed.ncbi.nlm.nih.gov/29665205
Autor:
Alan Kivitz, Xiaohui Ren, Steven E. Carsons, Michele Bombardieri, Pierre Moulin, Wan-Fai Ng, Arwa M. Farag, James S. Rush, Peter Gergely, David A. Isenberg, Bettina Bannert, Margit Zeher, Pascal Espie, Thomas Daikeler, Petra M Faerber, Athena Papas, Francesca Barone, Andrew M Wright, Michael Rotte, Benjamin A Fisher, Hans Ulrich Hockey, Simon J. Bowman, Grazyna Wieczorek, Maximilian G. Posch, David Floch, Cyrielle Dupuy
Publikováno v:
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 126:e203-e204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06288cd3d5d83b7694ce619d8c03ee4c
https://doi.org/10.1016/j.oooo.2018.05.036
https://doi.org/10.1016/j.oooo.2018.05.036
Autor:
L. Haeberli, Pascal Espie, L. Roth, R. Apolloni, Grazyna Wieczorek, M. Audet, Dhavalkumar D. Patel, Reto Baumgartner, A. Kunkler, Nathalie Stuber, Christoph Heusser, James S. Rush, Denise Sickert, Roger Grau, J. Munz, Melanie Ceci, Christian Bruns, D. Ristig, Francisco Cordoba, G. Robert, A. Cattini, M. Erard, Martin A. Schneider
Publikováno v:
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 15(11)
CD40-CD154 pathway blockade prolongs renal allograft survival in nonhuman primates (NHPs). However, antibodies targeting CD154 were associated with an increased incidence of thromboembolic complications. Antibodies targeting CD40 prolong renal allogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f1801746745572738bf84aee41843d
https://pubmed.ncbi.nlm.nih.gov/26139432
https://pubmed.ncbi.nlm.nih.gov/26139432