Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Pascal Drané"'
Autor:
Eva Tsaousidou, Jędrzej Chrzanowski, Pascal Drané, Grace Y. Lee, Nadine Bahour, Zeqiu Branden Wang, Shijun Deng, Zhe Cao, Kaimeng Huang, Yizhou He, Mateusz Kaminski, Dominika Michalek, Ekin Güney, Kalindi Parmar, Wojciech Fendler, Dipanjan Chowdhury, Gökhan S. Hotamışlıgil
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114337- (2024)
Summary: It is unclear whether metabolic health corresponds to reduced oncogenesis or vice versa. We study Tudor-interacting repair regulator (TIRR), an inhibitor of p53 binding protein 1 (53BP1)-mediated p53 activation, and the physiological consequ
Externí odkaz:
https://doaj.org/article/c830c19e952a4a9ebd6b580b85dca154
Autor:
Gaofeng Cui, Maria Victoria Botuyan, Pascal Drané, Qi Hu, Benoît Bragantini, James R. Thompson, David J. Schuller, Alexandre Detappe, Michael T. Perfetti, Lindsey I. James, Stephen V. Frye, Dipanjan Chowdhury, Georges Mer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The recruitment of 53BP1 to chromatin, mediated by its recognition of histone H4 dimethylated at lysine 20 (H4K20me2), is important for DNA double-strand break repair. Using a series of small molecule antagonists, we demonstrate a conformati
Externí odkaz:
https://doaj.org/article/0f5b7e97b6324cda80e7ab7f47fa3f98
Autor:
Khyati Meghani, Walker Fuchs, Alexandre Detappe, Pascal Drané, Ewa Gogola, Sven Rottenberg, Jos Jonkers, Ursula Matulonis, Elizabeth M. Swisher, Panagiotis A. Konstantinopoulos, Dipanjan Chowdhury
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 100-111 (2018)
Summary: BRCA1/2-mutated ovarian cancers (OCs) are defective in homologous recombination repair (HRR) of double-strand breaks (DSBs) and thereby sensitive to platinum and PARP inhibitors (PARPis). Multiple PARPis have recently received US Food and Dr
Externí odkaz:
https://doaj.org/article/b3d43fb7b6404de58fe771346b25edef
Autor:
Alexandre Detappe, Robert Langer, Romain Guieze, Pascal Drané, Douglas E. Biancur, Sijumon Kunjachan, G. Mike Makrigiorgos, Vincent Motto-Ros, Lucie Sancey, Olivier Tillement, Ross Berbeco
Publikováno v:
Journal of Controlled Release. 329:1283-1285
Autor:
Gaofeng Cui, Veronica Rendo, Huy V. Nguyen, Nishita Parnandi, Dipanjan Chowdhury, Rameen Beroukhim, Pascal Drané, Georges Mer, Matthias Altmeyer, Maria Victoria Botuyan, Michaela Remisova
Publikováno v:
Mol Cell
53BP1 influences genome stability via two independent mechanisms: (1) regulating DNA double-strand break (DSB) repair and (2) enhancing p53 activity. We discovered a protein, Tudor-interacting repair regulator (TIRR), that associates with the 53BP1 T
Autor:
Pascal Drané, Anchal Sharma, Yizhou Joseph He, Daryl A. Ronato, Chunyu Yang, Jie Bian, Alan D. D'Andrea, Jessica L. Moore, Subhajyoti De, Panagiotis A. Konstantinopoulos, Khyati Meghani, Alexandre Detappe, Joshi Niraj, Marie-Christine Caron, John G. Doench, Dipanjan Chowdhury, David E. Root, Gaëlle Legube, Jean-Yves Masson
Publikováno v:
Nature
Nature, Nature Publishing Group, 2018, 563 (7732), pp.522-526. ⟨10.1038/s41586-018-0670-5⟩
Nature, Nature Publishing Group, 2018, 563 (7732), pp.522-526. ⟨10.1038/s41586-018-0670-5⟩
Limited DNA end resection is the key to impaired homologous recombination in BRCA1-mutant cancer cells. Here, using a loss-of-function CRISPR screen, we identify DYNLL1 as an inhibitor of DNA end resection. The loss of DYNLL1 enables DNA end resectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b966e35510cb20242f24be01764ace
https://europepmc.org/articles/PMC7155769/
https://europepmc.org/articles/PMC7155769/
Autor:
Alan D. D'Andrea, John G. Doench, David E. Root, Panagiotis A. Konstantinopoulos, Jean-Yves Masson, Gaëlle Legube, Dipanjan Chowdhury, Jessica Miller, Chunyu Yang, Subhojyoti De, Pascal Drané, Anchal Sharma, Marie-Christine Caron, Jie Bian, Khyati Meghani, Niraj Joshi, Yizhou Joseph He, Daryl A. Ronato, Alexandre Detappe
Publikováno v:
Clinical Cancer Research. 25:GMM-027
High-grade serous ovarian carcinoma (HGSOC) patients with germline mutations in BRCA1/2 exhibit high sensitivity and improved outcome to double strand DNA break (DSB)-inducing agents [i.e. platinum and Poly(ADP-ribose) polymerase inhibitors (PARPi)]
Autor:
Catarina Oliveira, Dipanjan Chowdhury, Nishita Parnandi, J. Ross Chapman, James R. Thompson, Benoît Bragantini, Gaofeng Cui, Maria Victoria Botuyan, Debiao Zhao, Alexandre Detappe, Shweta Chaubey, Georges Mer, Pascal Drané, Marie Eve Brault
Dynamic protein interaction networks such as DNA double-strand break (DSB) signaling are modulated by post-translational modifications (PTMs). The DNA repair factor 53BP1 is a rare example of a protein whose PTM binding function can be switched on an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4fe4c237e6413f1742a0c5b8650b051
https://doi.org/10.1038/s41594-018-0083-z
https://doi.org/10.1038/s41594-018-0083-z
Autor:
Panagiotis A. Konstantinopoulos, Dipanjan Chowdhury, Alexandre Detappe, Ewa Gogola, Jos Jonkers, Khyati Meghani, Ursula A. Matulonis, Pascal Drané, Sven Rottenberg, Walker Fuchs, Elizabeth M. Swisher
Publikováno v:
Meghani, Khyati; Fuchs, Walker; Detappe, Alexandre; Drané, Pascal; Gogola, Ewa; Rottenberg, Sven; Jonkers, Jos; Matulonis, Ursula; Swisher, Elizabeth M; Konstantinopoulos, Panagiotis A; Chowdhury, Dipanjan (2018). Multifaceted Impact of MicroRNA 493-5p on Genome-Stabilizing Pathways Induces Platinum and PARP Inhibitor Resistance in BRCA2-Mutated Carcinomas. Cell reports, 23(1), pp. 100-111. Cell Press 10.1016/j.celrep.2018.03.038
Cell Reports, Vol 23, Iss 1, Pp 100-111 (2018)
Cell Reports, Vol 23, Iss 1, Pp 100-111 (2018)
Summary: BRCA1/2-mutated ovarian cancers (OCs) are defective in homologous recombination repair (HRR) of double-strand breaks (DSBs) and thereby sensitive to platinum and PARP inhibitors (PARPis). Multiple PARPis have recently received US Food and Dr
Autor:
Pascal Drané, Dipanjan Chowdhury
P53-binding protein 1 (53BP1) is a multi-functional double-strand break repair protein that is essential for class switch recombination in B lymphocytes and for sensitizing BRCA1-deficient tumours to poly-ADP-ribose polymerase-1 (PARP) inhibitors. Ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613c200fa019eed44a96d0656600cb35
https://europepmc.org/articles/PMC5531635/
https://europepmc.org/articles/PMC5531635/