Pharmacomodulations around an anti-Alzheimer drug-candidate

Autor: Sylvain Marc, Christophe Mésangeau, Mathilde Coevoet, Amélie Barczyk, Stéphane Burlet, Philippe Verwaerde, Cecilia Estrella, Cyrille Brantis, Nicolas Sergeant, Pascal Carato, Patricia Melnyk

Publikováno v: European Journal of Medicinal Chemistry Reports, Vol 4, Iss , Pp 100020- (2022)

Alzheimer's disease is a complex and multifactorial disease characterized by extracellular Aβ peptide deposits related to the deregulation of APP metabolism, intracellular aggregation of hyper and abnormally phosphorylated isoforms of Tau proteins,

Externí odkaz: https://doaj.org/article/d04e48aff8dd43daab307fe1dceece4c

New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

Autor: Nicolas Sergeant, Valérie Vingtdeux, Sabiha Eddarkaoui, Marion Gay, Caroline Evrard, Nicolas Le Fur, Cyril Laurent, Raphaelle Caillierez, Hélène Obriot, Paul-Emmanuel Larchanché, Amaury Farce, Mathilde Coevoet, Pascal Carato, Mostafa Kouach, Amandine Descat, Patrick Dallemagne, Valérie Buée-Scherrer, David Blum, Malika Hamdane, Luc Buée, Patricia Melnyk

Publikováno v: Neurobiology of Disease, Vol 129, Iss , Pp 217-233 (2019)

Alzheimer's Disease is a devastating dementing disease involving amyloid deposits, neurofibrillary tangles, progressive and irreversible cognitive impairment. Today, only symptomatic drugs are available and therapeutic treatments, possibly acting at

Externí odkaz: https://doaj.org/article/81981f930cdb439bb251f4f9165c75b8

Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists

Autor: Nathalie Hennuyer, Nicolas Lebegue, Morgan Le Naour, Monique Beucher-Gaudin, Daniel-Henri Caignard, Pascal Carato, Catherine Dacquet, Bart Staels, Veronique Leclerc, Patricia Melnyk, Aurelie Hurtevent

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.524-538. ⟨10.1080/14756366.2020.1713771⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2020, Journal of Enzyme Inhibition and Medicinal Chemistry, 35 (1), pp.524-538. ⟨10.1080/14756366.2020.1713771⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2020, 35 (1), pp.524-538. ⟨10.1080/14756366.2020.1713771⟩
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 524-538 (2020)

International audience; A series of nitrogen heterocycles containing α-ethoxyphenylpropionic acid derivatives were designed as dual PPARα/γ agonist ligands for the treatment of type 2 diabetes (T2D) and its complications. 6-Benzoyl-benzothiazol-2-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe2a5c92e218360919490d45f87c2dd
https://doi.org/10.1080/14756366.2020.1713771

Genotoxic effects of chlorinated disinfection by-products of 1,3-diphenylguanidine (DPG): cell-based in-vitro testing and formation potential during water disinfection

Autor: Mauricius Marques dos Santos, Camille Cheriaux, Shenglan Jia, Mikael Thomas, Hervé Gallard, Jean-Philippe Croué, Pascal Carato, Shane Allen Snyder

1,3-diphenylguanidine (DPG) is a commonly used rubber and polymer additive, that has been found to be one of the main leachate products of tire wear particles and from HDPE pipes. Its introduction to aquatic environments and potentially water supplie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea905bb442ab9d4c2f13d555fb1b1b75
https://hdl.handle.net/10356/161940

Benzo[d]thiazol-2(3H)-ones as new potent selective CB2 agonists with anti-inflammatory properties

Autor: Amélie Barczyk, Madjid Djouina, Nicolas Renault, Davy Baudelet, Valéria Moas Heloire, Pascal Carato, Régis Millet, Diana Escalante Rocha, Natascha Leleu-Chavain, Mathilde Body-Malapel

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 165, pp.347-362. ⟨10.1016/j.ejmech.2018.12.008⟩
European Journal of Medicinal Chemistry, 2019, 165, pp.347-362. ⟨10.1016/j.ejmech.2018.12.008⟩

International audience; The high distribution of CB receptors in immune cells suggests their important role in the control of inflammation. Growing evidence offers this receptor as an attractive therapeutic target: selective CB agonists are able to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa7bdfd8db615a5af2213f4367873a8
https://hal.univ-lille.fr/hal-02149143/file/S0223523418310456.pdf