A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

Autor: Grégory Menchon, Andrea E. Prota, Daniel Lucena-Agell, Pascal Bucher, Rolf Jansen, Herbert Irschik, Rolf Müller, Ian Paterson, J. Fernando Díaz, Karl-Heinz Altmann, Michel O. Steinmetz

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

Microtubule-targeting agents are used successfully as anticancer therapeutics. Here authors develop a fluorescence-anisotropy-based assay to identify and characterize ligands for the maytansine site of tubulin and provide crystal structures of identi

Externí odkaz: https://doaj.org/article/0ff5964567e04f11ab1504ca1c9d29cf

Value of performing routine postoperative liquid contrast swallow studies following robot-assisted Roux-en-Y gastric bypass1

Autor: Nicolas C. Buchs, Pascal Bucher, François Pugin, Monika Hagen, Gilles Chassot, Pascale Koutny-Fong, Philippe Morel

Publikováno v: Swiss Medical Weekly, Vol 142, Iss 1314 (2012)

QUESTIONS UNDER STUDY/PRINCIPLES: In most centers, Upper Gastrointestinal series (UGI) following Roux-en-Y Gastric Bypass (RYGB) is performed to rule out GJ anastomotic leak. According to the introduction of robotic technology associated with a hypot

Externí odkaz: https://doaj.org/article/82f0cb42624c48c580f27559a1e57dca

Optimizing laboratory cultures of Gammarus fossarum (Crustacea: Amphipoda) as a study organism in environmental sciences and ecotoxicology

Autor: Roman Alther, Andrin Krähenbühl, Pascal Bucher, Florian Altermatt

Publikováno v: Science of The Total Environment. 855:158730

Amphipods are among the most abundant macroinvertebrates in freshwater ecosystems of the Palaearctic and crucial for ecosystem functioning. Furthermore, their high sensitivity to environmental change and pollutants makes them widely used model organi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa4ae69bfb60bf8620487b5bf7cfa4f
https://doi.org/10.1016/j.scitotenv.2022.158730

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

Autor: Rolf Müller, Pascal Bucher, Grégory Menchon, Andrea E. Prota, Daniel Lucena-Agell, J. Fernando Díaz, Ian Paterson, Michel O. Steinmetz, Herbert Irschik, Rolf Jansen, Karl-Heinz Altmann

Publikováno v: Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature communications
Digital.CSIC. Repositorio Institucional del CSIC
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Nature Communications, 9 (1)

9 p.-5 fig.-1 tab. Menchon, Gregory et al.
Microtubule-targeting agents (MTAs) like taxol and vinblastine are among the most successful chemotherapeutic drugs against cancer. Here, we describe a fluorescence anisotropy-based assay that specifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30308d7700bf065e377a6280dedafa4
https://pubmed.ncbi.nlm.nih.gov/29844393

Intra-operative fluorescent cholangiography using indocyanin green during robotic single site cholecystectomy

Autor: Nicolas C, Buchs, Monika E, Hagen, François, Pugin, Francesco, Volonte, Pascal, Bucher, Eduardo, Schiffer, Philippe, Morel

Publikováno v: International Journal of Medical Robotics and Computer Assisted Surgery, Vol. 8, No 4 (2012) pp. 436-40

Very recently, robotic single site cholecystectomy (RSSC) has been reported feasible and safe for selected cases. While an intra-operative cholangiography can be performed, data is scarce with respect to its use. Indocyanin green (ICG) has been shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::436437b762181b890671b3f89be04b5e
https://archive-ouverte.unige.ch/unige:27768