Výsledky vyhledávání - "Pascal Bertholet"

Theoretical and experimental investigations on miconazole/cyclodextrin/acid complexes: Molecular modeling studies

Autor: Luc Delattre, Ziemons Eric, Georges Dive, Géraldine Piel, Brigitte Evrard, Pascal Bertholet, Valery Barillaro

Publikováno v: International Journal of Pharmaceutics. 342:152-160

The inclusion of miconazole into cyclodextrin cavity has been demonstrated by different authors. Preliminary studies have shown which fragment of the molecule is involved in the inclusion. In the present study, AM1 approximate molecular orbital calcu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059daa7a867a5e7d5e922d7360335dfc
https://doi.org/10.1016/j.ijpharm.2007.05.003

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Contribution of cyclodextrins in the development of different pharmaceutical formulations of a new matrix metalloproteinase inhibitor

Autor: Marie Piette, Luc Delattre, Didier Cataldo, Pascal Bertholet, Géraldine Piel, Maud Guéders, Brigitte Evrard

Publikováno v: Journal of Inclusion Phenomena and Macrocyclic Chemistry. 57:303-308

Ro 28-2653 is a new synthetic inhibitor of matrix metalloproteinases. The ability of these enzymes to degrade various components of the extracellular matrix seems to play a major role in tumors progression and is potentially effective against bronchi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c20906c112d429345877a0fac84feef2
https://doi.org/10.1007/s10847-006-9177-z

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Solid lipid microparticles as a sustained release system for pulmonary drug delivery

Autor: Brigitte Evrard, Jean-Michel Dogné, Séverine Jaspart, Géraldine Piel, Luc Delattre, Pascal Bertholet

Publikováno v: European journal of pharmaceutics and biopharmaceutics. 65(1):47-56

The controlled release of drugs for pulmonary delivery is a research field which has been so far rather unexploited but is currently becoming increasingly attractive. The introduction part of this research article first details the potential advantag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69dd1b94d4fac21ea94609284d5a501
https://researchportal.unamur.be/en/publications/d26acc33-0646-459a-9356-744889605771

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Cyclodextrins as a potential carrier in drug nebulization

Autor: Jean-Michel Foidart, M.P. Flament, Brigitte Evrard, Didier Cataldo, P. Leterme, A. Gayot, Luc Delattre, Maud Guéders, Pascal Bertholet, Géraldine Piel

Publikováno v: Journal of Controlled Release. 96:403-410

The inhalation route is widely studied for many drug applications focusing on either local or systemic distributions. One matter of concern is the solubilization of hydrophobic drugs. We have studied the feasibility of using different cyclodextrins (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a216be054208650022ce95441283cb
https://doi.org/10.1016/j.jconrel.2004.02.010

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Application of molecular modeling to the study of cyproterone acetate stability in the presence of cyclodextrin derivatives

Autor: S. Henry de Hassonville, Valery Barillaro, Georges Dive, Géraldine Piel, Brigitte Evrard, Pascal Bertholet, Luc Delattre

Publikováno v: Journal of Drug Delivery Science and Technology. 14:357-362

The ability of cyclodextrins (CDs) to increase the solubility of cyproterone acetate (CPA) was previously shown by phase-solubility and NMR studies [1]. In the present work, the influence of various CDs on the stability of CPA was studied in pH 6 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d17cdbddbca8b2d041f4b62ac3d387c
https://doi.org/10.1016/s1773-2247(04)50064-3

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Comparison of two methods currently used to determine the interaction between cyclodextrins and drugs: phase solubility diagrams and NMR spectroscopy

Autor: Bruno Perly, Stephane Moutard, Brigitte Evrard, Pascal Bertholet, Luc Delattre, Valery Barillaro, Géraldine Piel, Marie Piette, S. Henry de Hassonville

Publikováno v: Journal of Drug Delivery Science and Technology. 14:87-91

Two methods usually used in the literature to determine stability constant values (Kc) of cyclodextrin complexes were compared: the phase solubility diagram and NMR spectroscopy. Two model drugs were used to determine limitations of both techniques:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01ed6795a5f72c1cedda58dc4d27ee89
https://doi.org/10.1016/s1773-2247(04)50010-2

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[Untitled]

Autor: Sandrine Henry de Hassonville, Brigitte Evrard, Géraldine Piel, Luc Delattre, Valery Barillaro, Thierry Van Hees, Pascal Bertholet

Publikováno v: Journal of Inclusion Phenomena and Macrocyclic Chemistry. 44:271-274

Inclusion complexes of drugs into cyclodextrins (CDs) can be obtained at the solid state by means of supercritical dioxide (SCCO2). A successful inclusion with a yield >98.5% has been achieved with piroxicam and β-CD. The temperature and the time of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a770a1b6ac2a89ac718fe3a33da7e7f
https://doi.org/10.1023/a:1023084617964

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[Untitled]

Autor: Sandrine Henry De Hassonville, Bruno Perly, Géraldine Piel, Thierry Van Hees, Valéry Barillaro, Pascal Bertholet, Luc Delattre, Brigitte Evrard

Publikováno v: Journal of Inclusion Phenomena and Macrocyclic Chemistry. 44:289-292

Cyproterone acetate (CPA) is a steroidal antiandrogen with a progestogenic activity. Given that this molecule has a very poor water solubility (2.1 μg/mL), different cyclodextrins (CDs) were tested to form inclusion complexes and to increase solubil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4c2e78bffeaf1f826507a5dde7cb03f
https://doi.org/10.1023/a:1023099611604

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