Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Pascal Bailon"'
Autor:
Chee-Youb Won, Pascal Bailon
Publikováno v:
Expert Opinion on Drug Delivery. 6:1-16
PEGylation is a process in which one or more units of chemically activated polyethylene glycol reacts with a biomolecule, usually a protein, peptide, small molecule or oligonucleotide, creating a putative new molecular entity possessing physicochemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4069993987949316773b676613ca9907
https://doi.org/10.1517/17425240802650568
https://doi.org/10.1517/17425240802650568
Autor:
George Ehrlich, Pascal Bailon
Publikováno v:
Journal of Molecular Recognition. 11:121-125
The pFc′ fragments of a humanized IgG1 monoclonal antibody were generated by digestion with immobilized pepsin. These pFc′ fragments were separated from F(ab′)2 fragments by affinity chromatography. The pFc′ fragments corresponding to the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d69c3d26fb2ba0ea83ebfb63b9dff7c1
https://doi.org/10.1002/(sici)1099-1352(199812)11:1/6<121::aid-jmr406>3.0.co
https://doi.org/10.1002/(sici)1099-1352(199812)11:1/6<121::aid-jmr406>3.0.co
Autor:
Pascal Bailon, Wolfgang Berthold
Publikováno v:
Pharmaceutical Science & Technology Today. 1:352-356
Polyethylene glycol (PEG)-conjugated proteins belong to a new class of biomolecules that are neither proteins nor polymers, but which are hybrids of the two. PEG conjugation of biopharmaceuticals is now common practice in efforts to achieve sustained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ea4396aeef616f0c1b73cf780217d60
https://doi.org/10.1016/s1461-5347(98)00086-8
https://doi.org/10.1016/s1461-5347(98)00086-8
Publikováno v:
Regulatory Peptides. :433-439
OB protein (or leptin) administration causes a long-lasting reduction in food intake and body weight in obese ob/ob mice. Neuropeptide Y, a stimulator of feeding, has been proposed to be a major mediator of the biological actions of OB protein. To te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a843002473cec578c4719e871ab2817a
https://doi.org/10.1016/s0167-0115(98)00099-8
https://doi.org/10.1016/s0167-0115(98)00099-8
Autor:
Kurt Hollfelder, Mary C. Graves, Seth P. Monkarsh, Pascal Bailon, Palleroni Alicia Vallejo, Emil A. Russoman, Jill E. Porter, Yuemei Ma, Yu-Ching E. Pan, Doreen Ciolek, Hanspeter Michel, Swapan K. Roy, Barabara Debarbieri, Anthony Aglione
Publikováno v:
Analytical Biochemistry. 247:434-440
The success of recombinant interferon alpha in the clinic in part is limited by two properties of the protein: short serum half-life and immunogenicity. To improve these properties, interferon alpha-2a was conjugated with polyethylene glycol (PEG-500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246368842f1b7396edb4e8997684a7bc
https://doi.org/10.1006/abio.1997.2128
https://doi.org/10.1006/abio.1997.2128
Publikováno v:
Biomedical Chromatography. 8:236-241
A multipurpose fluidized-bed receptor-affinity purification system based upon the biological recognition between an immobilized receptor and its soluble protein ligands is described. The fluidized affinity sorbent consists of a soluble form of interl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1557549331f7af6ce08812def4b1258c
https://doi.org/10.1002/bmc.1130080508
https://doi.org/10.1002/bmc.1130080508
Autor:
Pascal Bailon, Dehra V. Hudson, Chung Nan Chang, Robert J. Kreitman, Cary L. Queen, Ira Pastan
Publikováno v:
International Journal of Cancer. 57:856-864
We have produced a single plasmid encoding both the heavy chain Fd domain (VH + CHl) of the anti-interleukin-2 receptor (IL2R) monoclonal antibody anti-Tac, and the anti-Tac light chain fused to PE40, a truncated derivative of Pseudomonas exotoxin. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a49ce153b4e7edfd2caf48feeb4fe9
https://doi.org/10.1002/ijc.2910570615
https://doi.org/10.1002/ijc.2910570615
Publikováno v:
Blood. 83:426-434
Anti-Tac(Fv)-PE40 is a recombinant single-chain immunotoxin composed of the variable domains of the monoclonal antibody anti-Tac, which binds to the p55 subunit of the interleukin-2 receptor (IL-2R), and a truncated form of Pseudomonas exotoxin (PE),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fa09d1c02d24e1817270c82a21975d8
https://doi.org/10.1182/blood.v83.2.426.426
https://doi.org/10.1182/blood.v83.2.426.426
Publikováno v:
Cellular Immunology. 147:167-179
Interleukin 2-stimulated human peripheral blood mononuclear cells (PBMC) generate lymphokine-activated killing (LAK). Using the IL-2 analogs R38A and F42K, which interact primarily with the beta and gamma subunits of the IL-2 receptor, we assessed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e39b86faab4a543affe2bdd3913b1b8
https://doi.org/10.1006/cimm.1993.1057
https://doi.org/10.1006/cimm.1993.1057
Autor:
Cheryl Spence, Ira Pastan, Michele Nachman, Robert J. Kreitman, Maurice K. Gately, Pascal Bailon
Publikováno v:
Bioconjugate Chemistry. 4:63-68
A chimeric, single chain antibody fused immunotoxin, denoted anti-Tac(Fv)-C3-PE38KDEL, was engineered and expressed in Escherichia coli. The microbially expressed anti-Tac(Fv)-C3-PE38KDEL was solubilized from inclusion bodies using guanidine hydrochl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334bc8c3b1cd03e1233b342652a887fa
https://doi.org/10.1021/bc00019a009
https://doi.org/10.1021/bc00019a009