Výsledky vyhledávání - "Pascal A. Pieters"

Cell-Free Characterization of Coherent Feed-Forward Loop-Based Synthetic Genetic Circuits

Autor: Tom F. A. de Greef, Pascal A. Pieters, Ardjan J. van der Linden, Jongmin Kim, Bryan L. Nathalia, Wilhelm T. S. Huck, Peng Yin

Publikováno v: ACS Synthetic Biology, 10(6), 1406-1416. American Chemical Society
bioRxiv
ACS Synthetic Biology
Acs Synthetic Biology, 10, 1406-1416
Acs Synthetic Biology, 10, 6, pp. 1406-1416

Regulatory pathways inside living cells employ feed-forward architectures to fulfill essential signal processing functions that aide in the interpretation of various types of inputs through noise-filtering, fold-change detection and adaptation. Altho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40fa20375a1eb62df2780619d9fdf10
https://doi.org/10.1021/acssynbio.1c00024

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DNA Input Classification by a Riboregulator-Based Cell-Free Perceptron

Autor: Ardjan J. van der Linden, Pascal A. Pieters, Mart W. Bartelds, Bryan L. Nathalia, Peng Yin, Wilhelm T. S. Huck, Jongmin Kim, Tom F. A. de Greef

Publikováno v: Acs Synthetic Biology, 11, 1510-1520
ACS Synthetic Biology, 11(4), 1510-1520. American Chemical Society
Acs Synthetic Biology, 11, 4, pp. 1510-1520

The ability to recognize molecular patterns is essential for the continued survival of biological organisms, allowing them to sense and respond to their immediate environment. The design of synthetic gene-based classifiers has been explored previousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e437fc155c616640cb40de7e8cd55f08
http://hdl.handle.net/2066/250100

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Akademický článek

Colorful protein-based fluorescent probes for collagen imaging.

Autor: Stijn J A Aper, Ariane C C van Spreeuwel, Mark C van Turnhout, Ardjan J van der Linden, Pascal A Pieters, Nick L L van der Zon, Sander L de la Rambelje, Carlijn V C Bouten, Maarten Merkx

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114983 (2014)

Real-time visualization of collagen is important in studies on tissue formation and remodeling in the research fields of developmental biology and tissue engineering. Our group has previously reported on a fluorescent probe for the specific imaging o

Externí odkaz: https://doaj.org/article/a138b360d3034db2859c825016277bb5

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Light-activated signaling in DNA-encoded sender-receiver architectures

Autor: Iuliia Myrgorodska, Pascal A. Pieters, Bas W. A. Bögels, Alex Joesaar, Rens Brouwers, Tom F. A. de Greef, Shuo Yang, Stephen Mann

Publikováno v: Yang, S, Pieters, P A, Joesaar, A, Bögels, B W A, Brouwers, R, Myrgorodska, I, Mann, S & Greef, T F A D 2020, ' Light-Activated Signaling in DNA-Encoded Sender–Receiver Architectures ', ACS Nano, vol. 14, no. 11, pp. 15992–16002 . https://doi.org/10.1021/acsnano.0c07537, https://doi.org/10.1021/acsnano.0c07537
ACS Nano
ACS Nano, 14(11). American Chemical Society

Collective decision making by living cells is facilitated by exchange of diffusible signals where sender cells release a chemical signal that is interpreted by receiver cells. A variety of nonliving artificial cell models have been developed in recen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf158527ad1fcec3fbcec06bfe450f7
https://doi.org/10.1021/acsnano.0c07537

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Light-activated signaling in DNA-encoded sender-receiver architectures

Autor: Stephen Mann, Shuo Yang, Rens Brouwers, Bas W. A. Bögels, Pascal A. Pieters, Tom F. A. de Greef, Alex Joesaar, Iuliia Myrgorodska

Publikováno v: ACS Nano, 14, 11, pp. 15992-16002
ACS Nano, 14, 15992-16002

Collective decision making by living cells is facilitated by exchange of diffusible signals where sender cells release a chemical signal that is interpreted by receiver cells. Biologists have started to unravel the underlying physicochemical determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd00f0e1b8c51e5c66de0f00311be6b
https://doi.org/10.1101/2020.06.10.144162

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Affinity Maturation of a Cyclic Peptide Handle for Therapeutic Antibodies Using Deep Mutational Scanning

Autor: Ardjan J. van der Linden, Tfa Tom de Greef, D Wanders, Maarten Merkx, Nathalie Hendrikse, Pascal A. Pieters, Bmg Brian Janssen, M Martijn van Rosmalen

Publikováno v: Journal of Biological Chemistry, 292(4), 1477-1489. American Society for Biochemistry and Molecular Biology Inc.

Meditopes are cyclic peptides that bind in a specific pocket in the antigen-binding fragment of a therapeutic antibody such as cetuximab. Provided their moderate affinity can be enhanced, meditope peptides could be used as specific non-covalent and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046f036ba4d75a4f99ae2dc06fb8e1ce
https://doi.org/10.1074/jbc.m116.764225

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A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

Autor: Zoe Swank, Maaruthy Yelleswarapu, Tom F. A. de Greef, Sebastian J. Maerkl, Pascal A. Pieters, Ardjan J. van der Linden, Wilhelm T. S. Huck

Publikováno v: Journal of Visualized Experiments
Journal of Visualized Experiments (JoVE), 152:e59655. MYJoVE Corporation
Journal of Visualized Experiments, 152

The limitations of cell-based synthetic biology are becoming increasingly apparent as researchers aim to develop larger and more complex synthetic genetic regulatory circuits. The analysis of synthetic genetic regulatory networks in vivo is time cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8439e2c2e827579d65f2cd4ec7377b3b
https://doi.org/10.3791/59655-v

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Kinetic analysis as a tool to distinguish pathway complexity in molecular assembly : an unexpected outcome of structures in competition

Autor: Tom F. A. de Greef, Pascal A. Pieters, Peter A. Korevaar, A. J. H. Spiering, Daan van der Zwaag, Albert J. Markvoort, E. W. Meijer

Publikováno v: Journal of the American Chemical Society, 137(39), 12677-12688. American Chemical Society

While the sensitive dependence of the functional characteristics of self-assembled nanofibers on the molecular structure of their building blocks is well-known, the crucial influence of the dynamics of the assembly process is often overlooked. For na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99e2d24d0e819e81a2285eb81fbc52b
https://research.tue.nl/en/publications/0735bb47-6f13-49d3-ab5b-db74e84cb428

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Colorful Protein-Based Fluorescent Probes for Collagen Imaging

Autor: Sja Stijn Aper, Ariane C. C. van Spreeuwel, Nick L. L. van der Zon, Maarten Merkx, Mark C. van Turnhout, Sander L. de la Rambelje, Pascal A. Pieters, Carlijn V. C. Bouten, Ardjan J. van der Linden

Publikováno v: PLoS ONE. Public Library of Science
PLoS ONE
PLoS ONE, Vol 9, Iss 12, p e114983 (2014)
PLoS ONE, 9(12), e114983-1/21. Public Library of Science

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4ba13493c5ba80df26fcdc751d66bb
https://pure.eur.nl/en/publications/445aa543-2200-48da-90f9-e4ade18275af

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Sigma Factor-Mediated Tuning of Bacterial Cell-Free Synthetic Genetic Oscillators

Autor: Emilien Dubuc, Wilhelm T. S. Huck, Ardjan J. van der Linden, Tom F. A. de Greef, Maaruthy Yelleswarapu, Pascal A. Pieters, Bob van Sluijs

Publikováno v: ACS Synthetic Biology
ACS Synthetic Biology, 7(12), 2879-2887. American Chemical Society

Cell-free transcription-translation provides a simplified prototyping environment to rapidly design and study synthetic networks. Despite the presence of a well characterized toolbox of genetic elements, examples of genetic networks that exhibit comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe0f7fc2c50ca44b98aa6c41c28d85e

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