Výsledky vyhledávání - "Pascal Loyer"

Akademický článek

Liposome-Mediated Gene Transfer in Differentiated HepaRG™ Cells: Expression of Liver Specific Functions and Application to the Cytochrome P450 2D6 Expression

Autor: Manuel Vlach, Hugo Coppens-Exandier, Agnès Jamin, Mathieu Berchel, Julien Scaviner, Christophe Chesné, Tristan Montier, Paul-Alain Jaffrès, Anne Corlu, Pascal Loyer

Publikováno v: Cells, Vol 11, Iss 23, p 3904 (2022)

The goal of this study was to establish a procedure for gene delivery mediated by cationic liposomes in quiescent differentiated HepaRG™ human hepatoma cells. We first identified several cationic lipids promoting efficient gene transfer with low to

Externí odkaz: https://doaj.org/article/82d3614871414e5fbb2585a0a912c8cd

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Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25

Autor: Riheb Jabeur, Caroline Corbel, Pascal Loyer, Annabelle Le Parc, Adélaide Le Grand, Arnaud Comte, Stéphane Bach, Gwenaëlle André-Leroux, Olivier Sire, Hedi Ben Mansour, Véronique Le Tilly

Publikováno v: Biochemistry
Biochemistry, 2023, 62 (9), pp.1452-1463. ⟨10.1021/acs.biochem.2c00691⟩

International audience; Tamoxifen, the gold standard drug for endocrine therapy for breast cancer, modulates the phosphorylation status of the TAU protein in Alzheimer’s disease by inhibiting CDK5 kinase activity. Its binding to p25 prevents CDK5/p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae605f3af201eae07a777f9a8d076221
https://doi.org/10.1021/acs.biochem.2c00691

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Akademický článek

Circumsporozoite Protein of Plasmodium berghei- and George Baker Virus A-Derived Peptides Trigger Efficient Cell Internalization of Bioconjugates and Functionalized Poly(ethylene glycol)-b-poly(benzyl malate)-Based Nanoparticles in Human Hepatoma Cells

Autor: Elise Vène, Kathleen Jarnouen, Catherine Ribault, Manuel Vlach, Yann Verres, Mickaël Bourgeois, Nicolas Lepareur, Sandrine Cammas-Marion, Pascal Loyer

Publikováno v: Pharmaceutics, Vol 14, Iss 4, p 804 (2022)

In order to identify the peptides, selected from the literature, that exhibit the strongest tropism towards human hepatoma cells, cell uptake assays were performed using biotinylated synthetic peptides bound to fluorescent streptavidin or engrafted o

Externí odkaz: https://doaj.org/article/a6bd928abdf74b0d8bb87eceb2b43b2a

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Akademický článek

Synthesis of Poly(Malic Acid) Derivatives End-Functionalized with Peptides and Preparation of Biocompatible Nanoparticles to Target Hepatoma Cells

Autor: Clarisse Brossard, Manuel Vlach, Elise Vène, Catherine Ribault, Vincent Dorcet, Nicolas Noiret, Pascal Loyer, Nicolas Lepareur, Sandrine Cammas-Marion

Publikováno v: Nanomaterials, Vol 11, Iss 4, p 958 (2021)

Recently, short synthetic peptides have gained interest as targeting agents in the design of site-specific nanomedicines. In this context, our work aimed at developing new tools for the diagnosis and/or therapy of hepatocellular carcinoma (HCC) by gr

Externí odkaz: https://doaj.org/article/32df697ded4e431ca2f6d28c3224dd43

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Akademický článek

Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy

Autor: Romain Eychenne, Christelle Bouvry, Mickael Bourgeois, Pascal Loyer, Eric Benoist, Nicolas Lepareur

Publikováno v: Molecules, Vol 25, Iss 17, p 4012 (2020)

Identified in 1973, somatostatin (SST) is a cyclic hormone peptide with a short biological half-life. Somatostatin receptors (SSTRs) are widely expressed in the whole body, with five subtypes described. The interaction between SST and its receptors l

Externí odkaz: https://doaj.org/article/125e9e20c9bd49ae82d77aca80f4174a

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Study of radiolabeled hepatotropic peptide derivatives for the diagnosis and treatment of hepatocellular carcinoma

Autor: Hanadi Nahas, Clarisse Brossard, Elise Vène, Stébastien Gouard, Michel Chérel, Mickaël Bourgeois, Pascal Loyer, Nicolas Lepareur, Sandrine Cammas-Marion

Publikováno v: 15th Workshop New modalities in Cancer Imaging and Therapy
15th Workshop New modalities in Cancer Imaging and Therapy, Oct 2022, Erquy, France. pp.S41-S41

International audience; Meeting Abstract P-19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c021b279f9a02b6622e22185acddd019
https://hal.science/hal-04011144

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Akademický článek

Cytochrome P450 1A1/2, 2B6 and 3A4 HepaRG Cell-Based Biosensors to Monitor Hepatocyte Differentiation, Drug Metabolism and Toxicity

Autor: Manuel Vlach, Nicolas Quesnot, Hélène Dubois-Pot-Schneider, Catherine Ribault, Yann Verres, Kilian Petitjean, Claudine Rauch, Fabrice Morel, Marie-Anne Robin, Anne Corlu, Pascal Loyer

Publikováno v: Sensors, Vol 19, Iss 10, p 2245 (2019)

Human hepatoma HepaRG cells express most drug metabolizing enzymes and constitute a pertinent in vitro alternative cell system to primary cultures of human hepatocytes in order to determine drug metabolism and evaluate the toxicity of xenobiotics. In

Externí odkaz: https://doaj.org/article/798c9c749f6646ef8bc3f35efb143899

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Gallium-68 and Copper-64 radiolabelling of hepatotropic GBVA10-9 or CPB peptide derivatives for hepatocellular carcinoma imaging

Autor: Clarisse Brossard, Mickaël Bourgeois, Stébastien Gouard, Christelle Bouvry, Elise Vène, Hanadi Nahas, Michel Chérel, Pascal Loyer, Sandrine Cammas-Marion, Nicolas Lepareur

Publikováno v: International Symposium on Radiopharmaceutical Sciences iSRS 2022
International Symposium on Radiopharmaceutical Sciences iSRS 2022, May 2022, Nantes, France. 108, pp.S153-S153, 2022, ⟨10.1016/s0969-8051(22)00327-4⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6e233a533c16708f0073928f448403
https://hal.science/hal-03715034

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Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing: Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression

Autor: Janeen H. Trembley, Pascal Loyer

Publikováno v: Seminars in Cell and Developmental Biology
Seminars in Cell and Developmental Biology, Elsevier, 2020, 107, pp.36-45. ⟨10.1016/j.semcdb.2020.04.016⟩
Seminars in Cell and Developmental Biology, 2020, 107, pp.36-45. ⟨10.1016/j.semcdb.2020.04.016⟩

International audience; Cyclin Dependent Kinases (CDKs) represent a large family of serine/threonine protein kinases that become active upon binding to a Cyclin regulatory partner. CDK/cyclin complexes recently identified, as well as "canonical" CDK/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bdc014390698c8bb477b2f0647afd8
https://doi.org/10.1016/j.semcdb.2020.04.016

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