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of 1 336
pro vyhledávání: '"Pascal, R. A."'
We propose a simple mathematical model to describe the mechanical relaxation of cells within a curved epithelial tissue layer represented by an arbitrary curve in two-dimensional space. The model represents the mechanics of the cell body either by st
Externí odkaz:
http://arxiv.org/abs/2406.19197
Autor:
Oren, Yaniv, Zanger, Moritz A., van der Vaart, Pascal R., Spaan, Matthijs T. J., Bohmer, Wendelin
Many modern reinforcement learning algorithms build on the actor-critic (AC) framework: iterative improvement of a policy (the actor) using policy improvement operators and iterative approximation of the policy's value (the critic). In contrast, the
Externí odkaz:
http://arxiv.org/abs/2406.01423
Publikováno v:
Proc Roy Soc A (2024) 480: 20230906
The propagation of signalling molecules within cellular networks is affected by network topology, but also by the spatial arrangement of cells in the networks. Understanding the collective reaction--diffusion behaviour in space of signals propagating
Externí odkaz:
http://arxiv.org/abs/2312.03221
Mathematical models describing the spatial spreading and invasion of populations of biological cells are often developed in a continuum modelling framework using reaction-diffusion equations. While continuum models based on linear diffusion are routi
Externí odkaz:
http://arxiv.org/abs/2310.07938
Mathematical modelling of biological population dynamics often involves proposing high fidelity discrete agent-based models that capture stochasticity and individual-level processes. These models are often considered in conjunction with an approximat
Externí odkaz:
http://arxiv.org/abs/2308.11086
Autor:
Karam, Pascal R, Bamieh, Bassam
Publikováno v:
J. Comput. Phys. 500 (2024)
We revisit the problem of spurious modes that are sometimes encountered in partial differential equations discretizations. It is generally suspected that one of the causes for spurious modes is due to how boundary conditions are treated, and we use t
Externí odkaz:
http://arxiv.org/abs/2306.15802
Autor:
Pascal R. D. Clephas, Jishnu Malgie, Jeroen Schaap, Stefan Koudstaal, Mireille Emans, Gerard C. M. Linssen, Grytsje A. deBoer, Loek vanHeerebeek, C. Jan Willem Borleffs, Olivier C. Manintveld, Vanessa vanEmpel, Sandra vanWijk, Mieke van denHeuvel, Carlos daFonseca, Kevin Damman, Jan vanRamshorst, Roland vanKimmenade, Arjen R. T. van deVen, René A. Tio, Dennis vanVeghel, Folkert W. Asselbergs, Rudolf A. deBoer, Peter van derMeer, Stephen J. Greene, Hans‐Peter Brunner‐La Rocca, Jasper J. Brugts
Publikováno v:
ESC Heart Failure, Vol 11, Iss 1, Pp 550-559 (2024)
Abstract Aims Current heart failure (HF) guidelines recommend to prescribe four drug classes in patients with HF with reduced ejection fraction (HFrEF). A clear challenge exists to adequately implement guideline‐directed medical therapy (GDMT) rega
Externí odkaz:
https://doaj.org/article/76fc22140ff146f4acc31d2d5d84e800
Understanding whether a population will survive and flourish or become extinct is a central question in population biology. One way of exploring this question is to study population dynamics using reaction-diffusion equations, where migration is usua
Externí odkaz:
http://arxiv.org/abs/2112.10989
Reaction-diffusion waves in multiple spatial dimensions advance at a rate that strongly depends on the curvature of the wave fronts. These waves have important applications in many physical, ecological, and biological systems. In this work, we analys
Externí odkaz:
http://arxiv.org/abs/2112.00928
Autor:
Whitaker, Mirinda M., Odell, Daniel, Deboeck, Pascal R., Stefanucci, Jeanine K., Okifuji, Akiko
Publikováno v:
In The Journal of Pain August 2024 25(8)