Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Pascal, Kessler"'
Autor:
Jelena Scekic-Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa Kan, Salim Megat, Pierre De Rossi, Stéphane Dieterlé, Raphaelle Cassel, Marguerite Jamet, Pascal Kessler, Diana Wiesner, Laura Tzeplaeff, Valérie Demais, Sonu Sahadevan, Katharina M. Hembach, Hans-Peter Muller, Gina Picchiarelli, Nibha Mishra, Stefano Antonucci, Sylvie Dirrig-Grosch, Jan Kassubek, Volker Rasche, Albert Ludolph, Anne-Laurence Boutillier, Francesco Roselli, Magdalini Polymenidou, Clotilde Lagier-Tourenne, Sabine Liebscher, Luc Dupuis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Mutations in the RNA binding protein FUS are associated with ALS. Here the authors show that in FUS knock-in mice there is a progressive increase in neuronal activity in the frontal cortex which is associated with altered synaptic gene expression.
Externí odkaz:
https://doaj.org/article/81d53965ba1c4f5cbe4fa11bc13113fd
Autor:
Anne-Cécile Van Baelen, Philippe Robin, Pascal Kessler, Arhamatoulaye Maïga, Nicolas Gilles, Denis Servent
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Peptide toxins from venoms have undergone a long evolutionary process allowing host defense or prey capture and making them highly selective and potent for their target. This has resulted in the emergence of a large panel of toxins from a wide divers
Externí odkaz:
https://doaj.org/article/5dbe36a627e94a97bf66bffda05673ae
Autor:
Justine Hadjerci, Anne Billet, Pascal Kessler, Gilles Mourier, Marine Ghazarian, Anthony Gonzalez, Christian Wunder, Nesrine Mabrouk, Eric Tartour, Denis Servent, Ludger Johannes
Publikováno v:
Cells, Vol 12, Iss 9, p 1291 (2023)
Many molecular targets for cancer therapy are located in the cytosol. Therapeutic macromolecules are generally not able to spontaneously translocate across membranes to reach these cytosolic targets. Therefore a strong need exists for tools that enha
Externí odkaz:
https://doaj.org/article/7e3ce7fe20a4467496df4c2ec0b3aca2
Autor:
Steve Reynaud, Suli-Anne Laurin, Justyna Ciolek, Peggy Barbe, Anne-Cécile Van Baelen, Michaël Susset, Florian Blondel, Marine Ghazarian, Julia Boeri, Margot Vanden Driessche, Grégory Upert, Gilles Mourier, Pascal Kessler, Laure Konnert, Rémy Beroud, Mathilde Keck, Denis Servent, Michel Bouvier, Nicolas Gilles
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2022, 65 (18), pp.12084-12094. ⟨10.1021/acs.jmedchem.2c00786⟩
Journal of Medicinal Chemistry, 2022, 65 (18), pp.12084-12094. ⟨10.1021/acs.jmedchem.2c00786⟩
International audience; The melanocortin 4 receptor (MC4R) plays a role in energy homeostasis and represents a target for treating energy balance disorders. For decades, synthetic ligands have been derived from MC4R endogenous agonists and antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bec2f8b9d6f9f5fb73a676a5fd189f3
https://doi.org/10.1021/acs.jmedchem.2c00786
https://doi.org/10.1021/acs.jmedchem.2c00786
Autor:
Anne Billet, Justine Hadjerci, Thi Tran, Pascal Kessler, Jonathan Ulmer, Gilles Mourier, Marine Ghazarian, Anthony Gonzalez, Robert Thai, Pauline Urquia, Anne-Cécile Van Baelen, Annalisa Meola, Ignacio Fernandez, Stéphanie Deville-Foillard, Ewan MacDonald, Léa Paolini, Frédéric Schmidt, Félix A. Rey, Michael S. Kay, Eric Tartour, Denis Servent, Ludger Johannes
The success of mRNA-based vaccines during the Covid-19 pandemic has highlighted the value of this new platform for vaccine development against infectious disease. However, the CD8+T cell response remains modest with mRNA vaccines, and these do not in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eac0af3c888bc3e547b1b72090eefd78
https://doi.org/10.1101/2023.05.15.540756
https://doi.org/10.1101/2023.05.15.540756
Autor:
Anne-Cécile Van Baelen, Xavier Iturrioz, Marion Chaigneau, Pascal Kessler, Catherine Llorens-Cortes, Denis Servent, Nicolas Gilles, Philippe Robin
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2330
Volume 24
Issue 3
Pages: 2330
The renin-angiotensin system (RAS) is one of the main regulatory systems of cardiovascular homeostasis. It is mainly composed of angiotensin-converting enzyme (ACE) and angiotensin II receptors AT1 and AT2. ACE and AT1 are targets of choice for the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d765d719861f66af20ec3c80c3710181
Autor:
Alice Karam, Lars Tebbe, Chantal Weber, Nadia Messaddeq, Laurette Morlé, Pascal Kessler, Uwe Wolfrum, Yvon Trottier
Publikováno v:
Neurobiology of Disease, Vol 80, Iss , Pp 15-28 (2015)
Huntington's disease (HD) is a neurodegenerative disorder caused by the toxic expansion of polyglutamine in the Huntingtin (HTT) protein. The pathomechanism is complex and not fully understood. Increasing evidence indicates that the loss of normal pr
Externí odkaz:
https://doaj.org/article/5ea3b120b8c14d8da8a1153622d2761e
Autor:
Anne-Cécile Van Baelen, Philippe Robin, Pascal Kessler, Arhamatoulaye Maïga, Nicolas Gilles, Denis Servent
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, 2022, 9, ⟨10.3389/fmolb.2022.811365⟩
Frontiers in Molecular Biosciences, Vol 9 (2022)
Frontiers in Molecular Biosciences, 2022, 9, ⟨10.3389/fmolb.2022.811365⟩
Frontiers in Molecular Biosciences, Vol 9 (2022)
International audience; Peptide toxins from venoms have undergone a long evolutionary process allowing host defense or prey capture and making them highly selective and potent for their target. This has resulted in the emergence of a large panel of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0f1607d7f08cfbe5f65ba588f1c077
https://pubmed.ncbi.nlm.nih.gov/35198603
https://pubmed.ncbi.nlm.nih.gov/35198603
Autor:
Laura Droctové, Manon Lancien, Vu Long Tran, Michaël Susset, Benoit Jego, Frederic Theodoro, Pascal Kessler, Gilles Mourier, Philippe Robin, Sékou Siramakan Diarra, Stefano Palea, Adrien Flahault, Amélia Chorfa, Maithé Corbani, Catherine Llorens-Cortes, Bernard Mouillac, Christiane Mendre, Alain Pruvost, Denis Servent, Charles Truillet, Nicolas Gilles
Publikováno v:
Theranostics
Theranostics, Ivyspring International Publisher, 2020, 10 (25), pp.11580-11594. ⟨10.7150/thno.47485⟩
Theranostics, Ivyspring International Publisher, 2020
Theranostics, 2020, 10 (25), pp.11580-11594. ⟨10.7150/thno.47485⟩
HAL
Theranostics, Ivyspring International Publisher, 2020, 10 (25), pp.11580-11594. ⟨10.7150/thno.47485⟩
Theranostics, Ivyspring International Publisher, 2020
Theranostics, 2020, 10 (25), pp.11580-11594. ⟨10.7150/thno.47485⟩
HAL
International audience; Rationale: MQ1, a snake toxin which targets with high nanomolar affinity and absolute selectivity for the type 2 vasopressin receptor (V2R), is a drug candidate for renal diseases and a molecular probe for imaging cells or org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::356848fbead96ed51d65e8ddfe36d68b
https://hal.archives-ouvertes.fr/hal-02960704
https://hal.archives-ouvertes.fr/hal-02960704
Autor:
Jelena, Scekic-Zahirovic, Mathieu, Fischer, Geoffrey, Stuart-Lopez, Thibaut, Burg, Johan, Gilet, Sylvie, Dirrig-Grosch, Christine, Marques, Marie-Christine, Birling, Pascal, Kessler, Caroline, Rouaux
Publikováno v:
Progress in neurobiology. 200
Amyotrophic lateral sclerosis (ALS) arises from the combined degeneration of motor neurons (MN) and corticospinal neurons (CSN). Recent clinical and pathological studies suggest that ALS might start in the motor cortex and spread along the corticofug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0aa40d398c2f738929ee1469394d26c
https://pubmed.ncbi.nlm.nih.gov/33309802
https://pubmed.ncbi.nlm.nih.gov/33309802