Imidazoquinoline Derivatives as Potential Inhibitors of InhA Enzyme and Mycobacterium tuberculosis

Autor: Pascal Hoffmann, Joëlle Azéma-Despeyroux, Fernanda Goncalves, Alessandro Stamilla, Nathalie Saffon-Merceron, Frédéric Rodriguez, Giulia Degiacomi, Maria Rosalia Pasca, Christian Lherbet

Publikováno v: Molecules, Vol 29, Iss 13, p 3076 (2024)

Tuberculosis is a serious public health problem worldwide. The search for new antibiotics has become a priority, especially with the emergence of resistant strains. A new family of imidazoquinoline derivatives, structurally analogous to triazolophtha

Externí odkaz: https://doaj.org/article/2c1ad0e2eed648a4ab889c946f63fcb2

Caco-2/HT29-MTX co-cultured cells as a model for studying physiological properties and toxin-induced effects on intestinal cells.

Autor: Pascal Hoffmann, Marion Burmester, Marion Langeheine, Ralph Brehm, Michael T Empl, Bettina Seeger, Gerhard Breves

Publikováno v: PLoS ONE, Vol 16, Iss 10, p e0257824 (2021)

Infectious gastrointestinal diseases are frequently caused by toxins secreted by pathogens which may impair physiological functions of the intestines, for instance by cholera toxin or by heat-labile enterotoxin. To obtain a functional model of the hu

Externí odkaz: https://doaj.org/article/45c0730f55d248448ba5588d540ad1cf

ESIPT-Active cinnamoyl pyrones are bright solid-state emitters: Revisited theoretical approach and experimental study

Autor: Emma Bremond, Martial Boggio-Pasqua, Nadine Leygue, Mokhtar Fodili, Pascal Hoffmann, Nathalie Saffon-Merceron, Rémi Métivier, Suzanne Fery-Forgues

Publikováno v: Dyes and Pigments
Dyes and Pigments, 2023, 211, pp.111046. ⟨10.1016/j.dyepig.2022.111046⟩

International audience; Excited-state intramolecular proton transfer (ESIPT) is a photophysical process that may lead to superior emission properties. For a long time, cinnamoyl pyrone (CP) derivatives have been classified as non-ESIPT molecules. Wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ad40db28cc82e9195dc201cde6da41
https://hal.science/hal-03934075/document

Crystal structure of a two-dimensional coordination polymer of formula [Zn(NDC)(DEF)] (H2NDC is naphthalene-2,6-dicarboxylic acid and DEF is N,N-diethylformamide)

Autor: Alain Vigroux, Pascal Hoffmann, Nathalie Saffon-Merceron

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 11, Pp 1759-1762 (2019)
Acta crystallographica. Section E, Crystallographic communications
Acta crystallographica. Section E, Crystallographic communications, International Union of Crystallography, 2019, 75 (11), pp.1759-1762. ⟨10.1107/S2056989019014142⟩
Acta Crystallographica Section E: Crystallographic Communications

The zinc metal organic framework poly[bis­(N,N-di­ethyl­formamide)(μ4-naphthalene-2,6-di­carboxyl­ato)(μ2-naphthalene-2,6-di­carboxyl­ato)dizinc(II)], built from windmill-type secondary building units and forming zigzag shaped two-dimensiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d40c5e1daf30c212dd128196d2b095
https://doi.org/10.1107/s2056989019014142

Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents

Autor: Babu L. Tekwani, Diego G. Ghiano, Nina Liu, Juan Manuel Belardinelli, Peter J. Tonge, Christian Lherbet, Héctor R. Morbidoni, Pascal Hoffmann, Julia Fernández de Luco, Ana Bortolotti, Guillermo R. Labadie, Alejandro I. Recio‐Balsells

Publikováno v: RSC Medicinal Chemistry
RSC Medicinal Chemistry, 2021, 12, pp.120. ⟨10.1039/D0MD00291G⟩
RSC Medicinal Chemistry, 2020, ⟨10.1039/D0MD00291G⟩
RSC Med Chem
RSC Medicinal Chemistry, Royal Society of Chemistry, 2021, 12, pp.120. ⟨10.1039/D0MD00291G⟩

International audience; Triclosan and isoniazid are known antitubercular compounds that have proven to be also active against Leishmania parasites. On these grounds, a collection of 37 diverse 1,2,3-triazoles based on the antitubercular molecules tri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2703be6122c287bdcc5c077d4cb32f17
https://hal.science/hal-03035897