Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Pascal, Heimer"'
Autor:
Ajay Abisheck Paul George, Pascal Heimer, Astrid Maaß, Jan Hamaekers, Martin Hofmann-Apitius, Arijit Biswas, Diana Imhof
Publikováno v:
ACS Omega, Vol 3, Iss 10, Pp 12330-12340 (2018)
Externí odkaz:
https://doaj.org/article/9805b41acb90457a9b3d489a9a5111a9
Autor:
Ajay Abisheck Paul George, Pascal Heimer, Enrico Leipold, Thomas Schmitz, Desiree Kaufmann, Daniel Tietze, Stefan H. Heinemann, Diana Imhof
Publikováno v:
Marine Drugs, Vol 17, Iss 7, p 390 (2019)
Cyclic µ-conotoxin PIIIA, a potent blocker of skeletal muscle voltage-gated sodium channel NaV1.4, is a 22mer peptide stabilized by three disulfide bonds. Combining electrophysiological measurements with molecular docking and dynamic simulations bas
Externí odkaz:
https://doaj.org/article/32742123ecf1403585f3326f2a9638c7
Publikováno v:
Molecules, Vol 17, Iss 4, Pp 4158-4185 (2012)
This review aims to provide a comprehensive overview of the recent advances made in the field of ionic liquids in peptide chemistry and peptide analytics.
Externí odkaz:
https://doaj.org/article/a179d47ce95647a2b3b158b3d568c844
Autor:
Arijit Biswas, Martin Hofmann-Apitius, Jan Hamaekers, Ajay Abisheck Paul George, Astrid Maaß, Diana Imhof, Pascal Heimer
Publikováno v:
ACS Omega
ACS Omega, Vol 3, Iss 10, Pp 12330-12340 (2018)
ACS Omega, Vol 3, Iss 10, Pp 12330-12340 (2018)
The study of protein conformations using molecular dynamics (MD) simulations has been in place for decades. A major contribution to the structural stability and native conformation of a protein is made by the primary sequence and disulfide bonds form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15db42500949ebafc1b8e3e518cbe10c
https://doi.org/10.1021/acsomega.8b01465
https://doi.org/10.1021/acsomega.8b01465
Autor:
Charlotte A. Bäuml, Evi Kostenis, Daniel Tietze, Tobias Benkel, Desireé Kaufmann, Max Crüsemann, Toni Kühl, Stefan Kehraus, Raphael Reher, Justin Patrick Odhiambo, Britta Nubbemeyer, Suvi Annala, Diana Imhof, Gabriele M. König, Pascal Heimer
Publikováno v:
ChemMedChem. 13:1634-1643
Direct targeting of intracellular Gα subunits of G protein-coupled receptors by chemical tools is a challenging task in current pharmacological studies and in the development of novel therapeutic approaches. In this study we analyzed novel FR900359-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05eccf1f87ce43469c8c7aa866a539f1
https://doi.org/10.1002/cmdc.201800304
https://doi.org/10.1002/cmdc.201800304
Autor:
Nils Lichtenberg, Diana Imhof, Raphael Menges, Kai Lawonn, V. Ageev, Pascal Heimer, A. A. Paul George
Publikováno v:
Computer Graphics Forum. 37:379-390
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc36e02153c7778c0968f54b2bce5536
https://doi.org/10.1111/cgf.13427
https://doi.org/10.1111/cgf.13427
Autor:
Diana Imhof, Pascal Heimer, Toshinori Hoshi, Matthias Westerhausen, Guido Gessner, Stefan H. Heinemann, Nirakar Sahoo, Ralf Mede, Gianna Hirth, Hans Henning Brewitz, Roland Schönherr, Sandip M. Swain
Publikováno v:
European Journal of Pharmacology. 815:33-41
Although toxic when inhaled in high concentrations, the gas carbon monoxide (CO) is endogenously produced in mammals, and various beneficial effects are reported. For potential medicinal applications and studying the molecular processes underlying th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e209118791b4d4ec111b4e13ff1859a5
https://doi.org/10.1016/j.ejphar.2017.10.006
https://doi.org/10.1016/j.ejphar.2017.10.006
Autor:
Daniel Tietze, Wadim Winschel, Miriam Böhm, Alesia A. Tietze, Enrico Leipold, Pascal Heimer, Stefan H. Heinemann, Diana Imhof
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1860:2053-2063
Background For a large number of conopeptides basic knowledge related to structure-activity relationships is unavailable although such information is indispensable with respect to drug development and their use as drug leads. Methods A combined exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1f2fae1e1e5e93a378e30c77b8e3f6
https://doi.org/10.1016/j.bbagen.2016.06.013
https://doi.org/10.1016/j.bbagen.2016.06.013
Publikováno v:
Talanta. 151:75-82
Propylene carbonate (PC) is a non-toxic solvent currently used in various pharmaceutical formulations. Consequently, a simple, cost-effective and most accurate analytical method for the quantification of this optical inert solvent is of major interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f036c4161889fa7bdb003b21398e7d
https://doi.org/10.1016/j.talanta.2016.01.022
https://doi.org/10.1016/j.talanta.2016.01.022
Publikováno v:
J Vis Exp
Peptides with a high number of cysteines are usually influenced regarding the three-dimensional structure by their disulfide connectivity. It is thus highly important to avoid undesired disulfide bond formation during peptide synthesis, because it ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e60c4b6e269889a91b539db5284c7ec0
https://pubmed.ncbi.nlm.nih.gov/30346393
https://pubmed.ncbi.nlm.nih.gov/30346393