Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Pascal, Geschwill"'
Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
Autor:
Pessah Yampolsky, Michael Koenen, Matias Mosqueira, Pascal Geschwill, Sebastian Nauck, Monika Witzenberger, Claudia Seyler, Thomas Fink, Mathieu Kruska, Claus Bruehl, Alexander P. Schwoerer, Heimo Ehmke, Rainer H. A. Fink, Andreas Draguhn, Dierk Thomas, Hugo A. Katus, Patrick A. Schweizer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The depolarizing funny current contributing to cardiac pacemaking is upregulated in the myocardium of failing and infarcted hearts, but whether the current is implied in disease mechanisms is unclear. Here the authors generate HCN4 transgenic mice an
Externí odkaz:
https://doaj.org/article/a8006cdc1e634c8e922f247e1bb32c74
Autor:
Patrick A. Schweizer, Fabrice F. Darche, Nina D. Ullrich, Pascal Geschwill, Boris Greber, Rasmus Rivinius, Claudia Seyler, Karin Müller-Decker, Andreas Draguhn, Jochen Utikal, Michael Koenen, Hugo A. Katus, Dierk Thomas
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-15 (2017)
Abstract Background Human induced pluripotent stem cells (hiPSC) harbor the potential to differentiate into diverse cardiac cell types. Previous experimental efforts were primarily directed at the generation of hiPSC-derived cells with ventricular ca
Externí odkaz:
https://doaj.org/article/c56a2ac66ee440beb66133c750c540da
Autor:
Pascal Geschwill, Isabel Weigl, Dierk Thomas, Hugo A. Katus, Patrick A. Schweizer, Farbod Sedaghat-Hamedani, Claus Bruehl, Miriam Reiss, Michael Koenen, Andreas Draguhn, Benjamin Meder
Publikováno v:
Biochemical and Biophysical Research Communications
Atrial fibrillation (AF) is the most frequent sustained arrhythmia and can lead to structural cardiac changes, known as tachycardia-induced cardiomyopathy (TIC). HCN4 is implicated in spontaneous excitation of the sinoatrial node, while channel dysfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f6e8810b16d004f53d0ae2faeb4c4a
https://doi.org/10.1016/j.bbrc.2019.08.150
https://doi.org/10.1016/j.bbrc.2019.08.150
Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
Autor:
Hugo A. Katus, Matias Mosqueira, Pascal Geschwill, Claudia Seyler, Rainer H. A. Fink, Dierk Thomas, Pessah Yampolsky, Monika Witzenberger, Michael Koenen, Thomas Fink, Patrick A. Schweizer, Mathieu Kruska, Sebastian Nauck, Claus Bruehl, Andreas Draguhn, Heimo Ehmke, Alexander P. Schwoerer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
HCN channels underlie the depolarizing funny current (If) that contributes importantly to cardiac pacemaking. If is upregulated in failing and infarcted hearts, but its implication in disease mechanisms remained unresolved. We generated transgenic mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224a1eea9f8d27759558602018201304
https://doaj.org/article/a8006cdc1e634c8e922f247e1bb32c74
https://doaj.org/article/a8006cdc1e634c8e922f247e1bb32c74
Autor:
Martin Both, Andreas Draguhn, Nadja Lehmann, Paul Grube, Jan-Oliver Hollnagel, Martin Kaiser, Christian Thome, Pascal Geschwill
Publikováno v:
HippocampusREFERENCES. 30(10)
The rodent hippocampus expresses a variety of neuronal network oscillations depending on the behavioral state of the animal. Locomotion and active exploration are accompanied by theta-nested gamma oscillations while resting states and slow-wave sleep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccb52d282fa2aeb85e384118ac2448b
https://pubmed.ncbi.nlm.nih.gov/32412680
https://pubmed.ncbi.nlm.nih.gov/32412680
Autor:
Tanja Weis, Bastian Schmack, Jennifer Franke, Hugo A. Katus, Norbert Frey, Fabian Wenz, Katharina Govorov, Derk Frank, Claudia Seyler, Matthias Karck, Dierk Thomas, Arjang Ruhparwar, Pascal Syren, Patrick A. Schweizer, Pascal Geschwill, Claus Bruehl, Patrick Lugenbiel
Publikováno v:
Basic Research in Cardiology. 112
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Concomitant heart failure (HF) poses a particular therapeutic challenge and is associated with prolonged atrial electrical refractoriness compared with non-failing hearts. We hypothesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56c5c3fa750df6271f59ba2a3565fe1e
https://doi.org/10.1007/s00395-016-0597-7
https://doi.org/10.1007/s00395-016-0597-7
Autor:
Patrick, Lugenbiel, Fabian, Wenz, Pascal, Syren, Pascal, Geschwill, Katharina, Govorov, Claudia, Seyler, Derk, Frank, Patrick A, Schweizer, Jennifer, Franke, Tanja, Weis, Claus, Bruehl, Bastian, Schmack, Arjang, Ruhparwar, Matthias, Karck, Norbert, Frey, Hugo A, Katus, Dierk, Thomas
Publikováno v:
Basic research in cardiology. 112(1)
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Concomitant heart failure (HF) poses a particular therapeutic challenge and is associated with prolonged atrial electrical refractoriness compared with non-failing hearts. We hypothesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88903e9a566ed2b5bdfb7fb89fd535e8
https://pubmed.ncbi.nlm.nih.gov/28005193
https://pubmed.ncbi.nlm.nih.gov/28005193