A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation.

Autor: Bridgette Janine Connell, Sui-Yuan Chang, Ekambaranellore Prakash, Rahima Yousfi, Viswaraman Mohan, Wilfried Posch, Doris Wilflingseder, Christiane Moog, Eiichi N Kodama, Pascal Clayette, Hugues Lortat-Jacob

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0165386 (2016)

Amongst the many strategies aiming at inhibiting HIV-1 infection, blocking viral entry has been recently recognized as a very promising approach. Using diverse in vitro models and a broad range of HIV-1 primary patient isolates, we report here that I

Externí odkaz: https://doaj.org/article/03008e7c28e1456694518fbc5d3f3038

A DNA telomerase vaccine for canine cancer immunotherapy

Autor: Pascal Clayette, Anne-Sophie Pailhes-Jimenez, Anna Kostrzak, Thomas Bestetti, Marion Julithe, Christine Kreuz, Simon Wain-Hobson, Pierre Langlade-Demoyen, Gabriel Chamel, Jessie Thalmensi, Christelle Liard, Emmanuèle Bourges, Ludovic Bourré, Elodie Pliquet, Marie Escande, Olivier Keravel, Thierry Huet

Publikováno v: Oncotarget

Telomerase reverse transcriptase (TERT) is highly expressed in more than 90% of canine cancer cells and low to absent in normal cells. Given that immune tolerance to telomerase is easily broken both naturally and experimentally, telomerase is an attr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3dec7a4e31082f5eed8f57e05e89588
https://doi.org/10.18632/oncotarget.26927

ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments

Autor: Didier Sauvaire, Philippe M. Loiseau, Sabrina Kali, Rahima Yousfi, Pascal Clayette, Daniel Gillet, Céline Bouclier, Noël Tordo, Jérôme Laporte, Amélie Goudet, Goulven Merer, Roman Lopez, Michel R. Popoff, Sandrine Cojean, Valérie Pons, Céline Aubenque, Claire Boulogne, Emmanuel Lemichez, Annette Fischer, Jean-Christophe Cintrat, Laetitia Panigai, Yu Wu, Cynthia Gillet, Roger Le Grand, Thomas Rudel, Robert A. Davey, Julien Barbier, Jo-Ana Herweg, Emilie Gobbo

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2017, 7 (1), pp.15567. ⟨10.1038/s41598-017-15466-7⟩
Scientific Reports, 2017, 7 (1), pp.15567. ⟨10.1038/s41598-017-15466-7⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Intracellular pathogenic microorganisms and toxins exploit host cell mechanisms to enter, exert their deleterious effects as well as hijack host nutrition for their development. A potential approach to treat multiple pathogen infections and that shou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bbdeb7abb18948ea072b7da556e2d4
https://hal-pasteur.archives-ouvertes.fr/pasteur-01675662/document

Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies

Autor: Karine Andrieux, Fawzia Bekkara-Aounallah, Christine Rogez-Kreuz, Ruxandra Gref, Patrick Couvreur, Sébastien Argote, Joachim Caron, Rym Skanji, Rahima Yousfi, Hervé Hillaireau, Laurent Bauduin, Nathalie Dereuddre-Bosquet, Didier Desmaële, Bernard Rousseau, Sinda Lepêtre, Pascal Clayette

Publikováno v: Biomaterials. 34:4831-4838

Due to their hydrophilic nature, most nucleoside reverse transcriptase inhibitors (NRTIs) display a variable bioavailability after oral administration and a poor control over their biodistribution, thus hampering their access to HIV sanctuaries. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd264b7b90668951ddf0067c0f0095e1
https://doi.org/10.1016/j.biomaterials.2013.03.022

A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation

Autor: Ekambaranellore Prakash, Rahima Yousfi, Hugues Lortat-Jacob, Christiane Moog, Wilfried Posch, Eiichi Kodama, Pascal Clayette, Bridgette Janine Connell, Doris Wilflingseder, Sui-Yuan Chang, Viswaraman Mohan

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2016, 11 (10), pp.e0165386. ⟨10.1371/journal.pone.0165386⟩
PLoS ONE, 2016, 11 (10), pp.e0165386. ⟨10.1371/journal.pone.0165386⟩
PLoS ONE, Vol 11, Iss 10, p e0165386 (2016)

International audience; Amongst the many strategies aiming at inhibiting HIV-1 infection, blocking viral entry has been recently recognized as a very promising approach. Using diverse in vitro models and a broad range of HIV-1 primary patient isolate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165adea6a7f05c7eb80db385d9d64140
https://hal.archives-ouvertes.fr/hal-01390491