Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Pasaje CFA"'
Autor:
Julie M. J. Verhoef, Rosemary Rochford, Philip J. Rosenthal, Graham P. Trevitt, Patrick K Tumwebaze, Barcelo C, Manuel Llinás, Jacquin C. Niles, Koen J. Dechering, Henderson R, Roger Bonnert, Dhelio Batista Pereira, Anna Caroline Campos Aguiar, Huijs T, Judith M. Bolscher, David A. Fidock, Tomas Yeo, Robert W. Sauerwein, Pasaje Cfa, Jake Baum, Patrick A. M. Jansen, Brice Campo, Roland A. Cooper, Taco W. A. Kooij, de Vries Le, María Belén Jiménez-Díaz, Iñigo Angulo-Barturen, Francisco J. Gamo, Josefine Striepen, Pedro H. H. Hermkens, Sergio Wittlin, Rafael Victorio Carvalho Guido, Kelly Rubiano, Justin Munro, Fernandez Bc, Laura M. Sanz, Karin M. J. Koolen, J. Schalkwijk, Alisje Churchyard
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (ACS) inhibitor to enter preclinical development. Our studies d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::defffb247aaafa1d1e8ba557aa91a1d8
https://doi.org/10.1101/2021.05.12.443866
https://doi.org/10.1101/2021.05.12.443866
Autor:
Collins JE; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA., Lee JW; Department of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, Norman OK 73019, USA., Rocamora F; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Saggu GS; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA., Wendt KL; Department of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, Norman OK 73019, USA., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Smick S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Santos NM; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA., Paes R; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA., Jiang T; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Mittal N; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Luth MR; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Chin T; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., Chang H; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA., McLellan JL; Department of Molecular Microbiology and Immunology and South Texas Center for Emerging Infectious Diseases, University of Texas San Antonio, San Antonio, TX 78249, USA., Morales-Hernandez B; Department of Molecular Microbiology and Immunology and South Texas Center for Emerging Infectious Diseases, University of Texas San Antonio, San Antonio, TX 78249, USA., Hanson KK; Department of Molecular Microbiology and Immunology and South Texas Center for Emerging Infectious Diseases, University of Texas San Antonio, San Antonio, TX 78249, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Desai SA; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD 20852, USA., Winzeler EA; Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA. Electronic address: ewinzeler@health.ucsd.edu., Cichewicz RH; Department of Chemistry and Biochemistry, Institute for Natural Products Applications & Research Technologies, University of Oklahoma, Norman OK 73019, USA. Electronic address: rhcichewicz@ou.edu., Chakrabarti D; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826, USA. Electronic address: dchak@ucf.edu.
Publikováno v:
Cell chemical biology [Cell Chem Biol] 2024 Feb 15; Vol. 31 (2), pp. 312-325.e9. Date of Electronic Publication: 2023 Nov 22.
Autor:
Xie SC; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Wang Y; School of Pharmacy, University College London, London, WC1N 1AX, UK., Morton CJ; Biomedical Manufacturing Program, CSIRO, Clayton South, VIC, Australia., Metcalfe RD; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, 21702, USA., Dogovski C; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Dunn E; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Luth MR; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Kumpornsin K; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Calibr, Division of the Scripps Research Institute, La Jolla, CA, 92037, USA., Istvan ES; Division of Infectious Diseases, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Park JS; Research Institute of Pharmaceutical Sciences and Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea., Fairhurst KJ; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA., Ketprasit N; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Yeo T; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA., Yildirim O; Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Bhebhe MN; School of Chemistry, University of Sydney, Camperdown, NSW, 2006, Australia., Klug DM; School of Pharmacy, University College London, London, WC1N 1AX, UK., Rutledge PJ; School of Chemistry, University of Sydney, Camperdown, NSW, 2006, Australia., Godoy LC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Dey S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., De Souza ML; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Siqueira-Neto JL; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA., Du Y; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Puhalovich T; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Amini M; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Shami G; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Loesbanluechai D; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Nie S; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Williamson N; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia., Jana GP; TCG Lifesciences Private Limited, Salt-Lake Electronics Complex, Kolkata, India., Maity BC; TCG Lifesciences Private Limited, Salt-Lake Electronics Complex, Kolkata, India., Thomson P; School of Chemistry, The University of Edinburgh, Edinburgh, EH9 3JJ, UK., Foley T; School of Chemistry, The University of Edinburgh, Edinburgh, EH9 3JJ, UK., Tan DS; Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Han BW; Research Institute of Pharmaceutical Sciences and Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea., Goldberg DE; Division of Infectious Diseases, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA., Burrows J; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215, Geneva 15, Switzerland., Fidock DA; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY, 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, 10032, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY, 10032, USA., Lee MCS; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Wellcome Centre for Anti-Infectives Research, Biological Chemistry and Drug Discovery, University of Dundee, Dundee, DD1 4HN, UK., Winzeler EA; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, 92093, USA. ewinzeler@health.ucsd.edu., Griffin MDW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia. mgriffin@unimelb.edu.au., Todd MH; School of Pharmacy, University College London, London, WC1N 1AX, UK. matthew.todd@ucl.ac.uk.; Structural Genomics Consortium, University College London, London, WC1N 1AX, UK. matthew.todd@ucl.ac.uk., Tilley L; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, 3010, Australia. ltilley@unimelb.edu.au.
Publikováno v:
Nature communications [Nat Commun] 2024 Jan 31; Vol. 15 (1), pp. 937. Date of Electronic Publication: 2024 Jan 31.
Autor:
Valleau D; Whitehead Institute, Cambridge, MA, USA., Sidik SM; Whitehead Institute, Cambridge, MA, USA., Godoy LC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Acevedo-Sánchez Y; Biology Department, Massachusetts Institute of Technology, Cambridge, MA, USA., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Huynh MH; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA., Carruthers VB; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Lourido S; Whitehead Institute, Cambridge, MA, USA.; Biology Department, Massachusetts Institute of Technology, Cambridge, MA, USA.
Publikováno v:
The EMBO journal [EMBO J] 2023 Dec 01; Vol. 42 (23), pp. e113155. Date of Electronic Publication: 2023 Oct 27.
Autor:
Armstrong JF; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK., Campo B; Medicines for Malaria Venture, Geneva, Switzerland., Alexander SPH; School of Life Sciences, University of Nottingham Medical School, Nottingham, UK., Arendse LB; Drug Discovery and Development Centre (H3D), South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Cheng X; Global Health Drug Discovery Institute, Beijing, China., Davenport AP; Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK., Faccenda E; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA., Godinez-Macias KP; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego (UCSD), La Jolla, California, USA., Harding SD; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK., Kato N; Global Health Drug Discovery Institute, Beijing, China., Lee MCS; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK., Luth MR; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA., Mazitschek R; Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA., Mittal N; Thermo Fisher Scientific, San Diego, California, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Okombo J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA., Ottilie S; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Probst AS; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA., Rawat M; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK., Rocamora F; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA., Sakata-Kato T; Global Health Drug Discovery Institute, Beijing, China., Southan C; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK., Spedding M; Spedding Research Solutions SAS, Le Vésinet, France., Tye MA; Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA., Yang T; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, USA., Zhao N; Global Health Drug Discovery Institute, Beijing, China., Davies JA; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK.
Publikováno v:
British journal of pharmacology [Br J Pharmacol] 2023 Aug; Vol. 180 (15), pp. 1899-1929. Date of Electronic Publication: 2023 Jun 10.
Autor:
Xie SC; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Wang Y; School of Pharmacy, University College London, London WC1N 1AX, United Kingdom., Morton CJ; Biomedical Manufacturing Program, CSIRO, Clayton South, Australia., Metcalfe RD; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA., Dogovski C; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Dunn E; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Luth MR; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Kumpornsin K; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Calibr, Division of the Scripps Research Institute, La Jolla, CA 92037, USA., Istvan ES; Division of Infectious Diseases, Department of Medicine, Washington University in St. Louis, USA., Park JS; Research Institute of Pharmaceutical Sciences & Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Fairhurst KJ; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA., Ketprasit N; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Yeo T; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA., Yildirim O; Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Bhebhe MN; School of Chemistry, University of Sydney, Camperdown, NSW 2006, Australia., Klug DM; School of Pharmacy, University College London, London WC1N 1AX, United Kingdom., Rutledge PJ; School of Chemistry, University of Sydney, Camperdown, NSW 2006, Australia., Godoy LC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Dey S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., De Souza ML; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Siqueira-Neto JL; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Du Y; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Puhalovich T; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Amini M; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Shami G; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Loesbanluechai D; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom., Nie S; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Williamson N; Melbourne Mass Spectrometry and Proteomics Facility, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Jana GP; TCG Lifesciences Private Limited, Salt-lake Electronics Complex, Kolkata, India., Maity BC; TCG Lifesciences Private Limited, Salt-lake Electronics Complex, Kolkata, India., Thomson P; School of Chemistry, The University of Edinburgh, Edinburgh EH9 3JJ, United Kingdom., Foley T; School of Chemistry, The University of Edinburgh, Edinburgh EH9 3JJ, United Kingdom., Tan DS; Chemical Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Han BW; Research Institute of Pharmaceutical Sciences & Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea., Goldberg DE; Division of Infectious Diseases, Department of Medicine, Washington University in St. Louis, USA., Burrows J; Medicines for Malaria Venture, 20, Route de Pré-Bois 1215, Geneva 15, Switzerland., Fidock DA; Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Medical Center, New York, NY 10032, USA.; Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.; Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032, USA., Lee MCS; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, CB10 1SA, United Kingdom.; Wellcome Centre for Anti-Infectives Research, Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 4HN, United Kingdom., Winzeler EA; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA., Griffin MDW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia., Todd MH; School of Pharmacy, University College London, London WC1N 1AX, United Kingdom.; Structural Genomics Consortium, University College London, London WC1N 1AX, United Kingdom., Tilley L; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC 3010, Australia.
Publikováno v:
Research square [Res Sq] 2023 Jul 27. Date of Electronic Publication: 2023 Jul 27.
Autor:
Deni I; Center for Malaria Therapeutics and Antimicrobial Resistance and Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Stokes BH; Center for Malaria Therapeutics and Antimicrobial Resistance and Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Ward KE; Center for Malaria Therapeutics and Antimicrobial Resistance and Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Fairhurst KJ; Center for Malaria Therapeutics and Antimicrobial Resistance and Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Yeo T; Center for Malaria Therapeutics and Antimicrobial Resistance and Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Akbar S; School of Molecular Biosciences, University of Glasgow, Glasgow, Scotland, UK., Park H; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Muir R; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Bick DS; Center for Malaria Therapeutics and Antimicrobial Resistance and Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Zhan W; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Zhang H; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Liu YJ; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Ng CL; Global Center for Health Security, University of Nebraska Medical Center, Omaha, NE, USA; Department of Biology, University of Nebraska Omaha, Omaha, NE, USA; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA., Kirkman LA; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY., Almaliti J; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Jordan, Amman, Jordan., Gould AE; Takeda Development Center Americas, Inc., Cambridge, MA 02139, USA., Duffey M; Medicines for Malaria Venture, Geneva, Switzerland., O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Uhlemann AC; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., da Fonseca PCA; School of Molecular Biosciences, University of Glasgow, Glasgow, Scotland, UK., Gerwick WH; Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA., Lin G; Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA., Bogyo M; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA., Fidock DA; Center for Malaria Therapeutics and Antimicrobial Resistance and Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: df2260@cumc.columbia.edu.
Publikováno v:
Cell chemical biology [Cell Chem Biol] 2023 May 18; Vol. 30 (5), pp. 470-485.e6. Date of Electronic Publication: 2023 Mar 23.
Autor:
Bopp S; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Summers RL; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Magistrado-Coxen P; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Schindler KA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Corpas-Lopez V; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA., Mok S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Dey S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Smick S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Nasamu AS; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Demas AR; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Milne R; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Wiedemar N; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Corey V; Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, CA, USA., Gomez-Lorenzo MG; Tres Cantos Medicines Research and Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain., Franco V; Tres Cantos Medicines Research and Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain., Early AM; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Lukens AK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Milner D; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA., Furtado J; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Gamo FJ; Tres Cantos Medicines Research and Development Campus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain., Winzeler EA; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Volkman SK; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA.; College of Natural, Behavioral, and Health Sciences, Simmons University, Boston, MA, USA., Duffey M; Medicines for Malaria Venture, Geneva, Switzerland., Laleu B; Medicines for Malaria Venture, Geneva, Switzerland., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Wyllie S; Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Wirth DF; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. dfwirth@hsph.harvard.edu.; Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA. dfwirth@hsph.harvard.edu.
Publikováno v:
Nature communications [Nat Commun] 2023 Mar 16; Vol. 14 (1), pp. 1455. Date of Electronic Publication: 2023 Mar 16.
Autor:
Arendse LB; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town 7701, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa.; South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Murithi JM; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA., Qahash T; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.; Huck Center for Malaria Research, Pennsylvania State University, University Park, PA 16802, USA., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Godoy LC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Dey S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Gibhard L; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Ghidelli-Disse S; Cellzome GmbH, a GSK Company, Heidelberg 69117, Germany., Drewes G; Cellzome GmbH, a GSK Company, Heidelberg 69117, Germany., Bantscheff M; Cellzome GmbH, a GSK Company, Heidelberg 69117, Germany., Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus-Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid 28760, Spain., Fienberg S; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, Cape Town 7701, South Africa.; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Wambua L; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa.; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Gachuhi S; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South Africa., Coertzen D; 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Publikováno v:
Science translational medicine [Sci Transl Med] 2022 Oct 19; Vol. 14 (667), pp. eabo7219. Date of Electronic Publication: 2022 Oct 19.
Autor:
Russell TJ; Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America.; Huck Institutes Center for Eukaryotic Gene Regulation (CEGR), Pennsylvania State University, State College, Pennsylvania, United States of America.; Huck Institutes Center for Malaria Research (CMaR), Pennsylvania State University, State College, Pennsylvania, United States of America.; Huck Institutes Center for Infectious Disease Dynamics, Pennsylvania State University, State College, Pennsylvania, United States of America., De Silva EK; Lewis-Singler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America., Crowley VM; Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America., Shaw-Saliba K; Department of Molecular Biology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Dube N; Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America., Josling G; Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America.; Huck Institutes Center for Malaria Research (CMaR), Pennsylvania State University, State College, Pennsylvania, United States of America.; Huck Institutes Center for Infectious Disease Dynamics, Pennsylvania State University, State College, Pennsylvania, United States of America., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America., Kouskoumvekaki I; Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark., Panagiotou G; Systems Biology and Bioinformatics, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knöll Institute, Jena, Germany.; Department of Medicine, the University of Hong Kong, Hong Kong SAR, China., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America., Jacobs-Lorena M; Department of Molecular Biology and Immunology, Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America., Denise Okafor C; Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America.; Department of Chemistry, Pennsylvania State University, State College, Pennsylvania, United States of America., Gamo FJ; Global Health Medicines, GlaxoSmithKline, Tres Cantos, Spain., Llinás M; Department of Biochemistry and Molecular Biology, Pennsylvania State University, State College, Pennsylvania, United States of America.; Huck Institutes Center for Eukaryotic Gene Regulation (CEGR), Pennsylvania State University, State College, Pennsylvania, United States of America.; Huck Institutes Center for Malaria Research (CMaR), Pennsylvania State University, State College, Pennsylvania, United States of America.; Huck Institutes Center for Infectious Disease Dynamics, Pennsylvania State University, State College, Pennsylvania, United States of America.; Department of Chemistry, Pennsylvania State University, State College, Pennsylvania, United States of America.
Publikováno v:
PLoS pathogens [PLoS Pathog] 2022 Oct 12; Vol. 18 (10), pp. e1010887. Date of Electronic Publication: 2022 Oct 12 (Print Publication: 2022).