Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Parviz Meghji"'
Autor:
David J. Dick, Max J. Lab, Mark E.S. Bailey, Keith J. Johnson, Sirfraz A. Nazir, Parviz Meghji
Publikováno v:
Journal of Molecular and Cellular Cardiology. 29:3147-3155
Cardiac remodelling and hypertrophy induced by chronic haemodynamic overload (stretch) eventually leads to a decrease in cardiac function, an increased incidence of ventricular arrhythmia and mortality. The mechanisms by which myocytes sense haemodyn
Autor:
Parviz Meghji
Publikováno v:
Drug Development Research. 28:214-219
Adenine nucleotides are released into the interstitial space during platelet thrombus formation and neurotransmission. ATP has also been reported to be released from the heart and endothelial cells in some studies. Ecto ATPase, ADPase, and 5′-nucle
Autor:
Parviz Meghji, Andrew C. Newby
Publikováno v:
Neurochemistry international. 16(3)
Two extreme and non-exclusive hypotheses can be put forward to account for the largely inhibitory actions of adenosine on neural activity. Adenosine formation may be linked to the balance between formation and degradation of cytoplasmic ATP and hence
Autor:
Geoffrey Burnstock, Parviz Meghji
Publikováno v:
Life sciences. 57(8)
The plasma membrane ATPase on the human umbilical vein endothelial cell line (ECV304) was demonstrated to be an ecto-enzyme. Hydrolysis of ATP was measured by monitoring the appearance of inorganic phosphorus. Hydrolysis of extracellular ATP was inse
Autor:
Parviz Meghji, Geoffrey Burnstock
Publikováno v:
British Journal of Pharmacology. 79:211-218
1 The effects of adenyl compounds were examined on the rat atrium and ventricle. 2 Adenosine, adenosine 5'-monophosphate, adenosine 5'-diphosphate, adenosine 5'-triphosphate (ATP) and beta, gamma-methylene ATP (APPCP) produced negative inotropic effe
Publikováno v:
Biochemical Journal. 249:695-703
1. The activities of ecto- and cytosolic 5′-nucleotidase (EC 3.1.3.5), adenosine kinase (EC 2.7.1.20), adenosine deaminase (EC 3.5.4.4) and AMP deaminase (EC 3.5.4.6) were compared in ventricular myocardium from man, rats, rabbits, guinea pigs, pig
Autor:
Geoffrey Burnstock, Parviz Meghji
Publikováno v:
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 77:295-300
1. 1. The effects of adenyl compounds were examined on dogfish atria and ventricles. 2. 2. Adenosine, ATP, β, γ-methylene ATP (APPCP) and 2-chloroadenosine produced negative inotropic and chronotropic effects on the dogfish atrium, which were antag
Publikováno v:
International Journal of Biochemistry. 20:1335-1341
1. 1. In rat heart perfused with adenosine (10 −6 M), dilazep (10 −4 M) inhibited incorporation of adenosine into nucleotides (an index of nucleoside transport and phosphorylation) to a greater extent (70%) than metabolism to inosine and uric aci
Publikováno v:
Journal of Neurochemistry. 53:1852-1860
Adenosine formation and release were studied in 48-h-old cultured ciliary ganglia and confluent peripheral and CNS glial cultures from embryonic chicks. Metabolic poisoning induced by 30 mM 2-deoxyglucose and 2 micrograms/ml oligomycin reduced ATP co