Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Parviz Ghahramani"'
Autor:
Antonia Periclou, Susan Willavize, David Jaworowicz, Julie Passarell, Timothy Carrothers, Parviz Ghahramani, Suresh Durgam, Willie Earley, Margit Kapás, Tatiana Khariton
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 362-371 (2020)
Population pharmacokinetic/pharmacodynamic modeling (via NONMEM) was used to describe longitudinal exposure‐response relationships for total cariprazine (sum of cariprazine and its major active metabolites) in 2,558 patients with schizophrenia or b
Externí odkaz:
https://doaj.org/article/723d33f3a14e43b0947d2293e493193c
Autor:
David B Huang, Kimberly M Brothers, Jonathan B Mandell, Masashi Taguchi, Peter G Alexander, Dana M Parker, Dean Shinabarger, Chris Pillar, Ian Morrissey, Stephen Hawser, Parviz Ghahramani, Despina Dobbins, Nicholas Pachuda, Ronald Montelaro, Jonathan D Steckbeck, Kenneth L Urish
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0274815 (2022)
The absence of novel antibiotics for drug-resistant and biofilm-associated infections is a global public health crisis. Antimicrobial peptides explored to address this need have encountered significant development challenges associated with size, tox
Externí odkaz:
https://doaj.org/article/59eaa2222fdc466fabfaa701ec609c4a
Autor:
Timothy J. Carrothers, Luann Phillips, Tatiana Khariton, Antonia Periclou, Margit Kapás, Parviz Ghahramani
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics
Background and Objectives Cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist, is approved for the treatment of adults with schizophrenia (1.5–6 mg/day) and manic/mixed (3–6 mg/day) episodes associated with bipolar I disorder. Th
Autor:
Willie Earley, Julie Passarell, Parviz Ghahramani, Suresh Durgam, Antonia Periclou, Tatiana Khariton, David J. Jaworowicz, Margit Kapás, Susan Willavize, Timothy J. Carrothers
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 362-371 (2020)
Clinical and Translational Science
Clinical and Translational Science
Population pharmacokinetic/pharmacodynamic modeling (via NONMEM) was used to describe longitudinal exposure-response relationships for total cariprazine (sum of cariprazine and its major active metabolites) in 2,558 patients with schizophrenia or bip
Publikováno v:
Antimicrob Agents Chemother
Background: In this first in human study, PLG0206, a novel engineered cationic antimicrobial peptide was evaluated for safety, tolerability and pharmacokinetics when intravenously administered as a single dose to healthy subjects. Methods: Six cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a46041a9104a6e33b620f151ba0386a
https://europepmc.org/articles/PMC8765304/
https://europepmc.org/articles/PMC8765304/
Autor:
Ganga S Moorthy, Rachel G Greenberg, Chi D Hornik, Cara Cassino, Parviz Ghahramani, Karan R Kumar, Vance G Fowler, Michael Cohen-Wolkowiez
Publikováno v:
Clin Infect Dis
Exebacase, an antistaphylococcal lysin produced from a bacteriophage-encoded gene, is a promising adjunctive therapy for severe methicillin-resistant Staphylococcus aureus infections. We describe the first infant to receive exebacase, dosing, and pha
Publikováno v:
Open Forum Infectious Diseases
Background Exebacase, a novel, antibacterial direct lytic agent for the treatment of S. aureus bacterimia and endocarditis, studied in Phase 1 and 2 trials, demonstrated potential to improve clinical outcomes when used in addition to conventional ant
Autor:
Yiyun Huang, Nabeel Nabulsi, Deepak Cyril D'Souza, Anissa Abi-Dargham, Margit Kapás, Ragy R. Girgis, Yih Lee, Mark Slifstein, Ashok Rakhit, Bela Kiss, Suresh Durgam, Antonia Periclou, Parviz Ghahramani, Nika Adham, István Laszlovszky, Richard E. Carson
Publikováno v:
Psychopharmacology
Rationale Second-generation antipsychotics occupy dopamine D2 receptors and act as antagonists or partial agonists at these receptors. While these drugs alleviate positive symptoms in patients with schizophrenia, they are less effective for treating
Autor:
Tomefa E. Asempa, Cara Cassino, Raymond Schuch, Parviz Ghahramani, Arnold S. Bayer, David P. Nicolau, Teresa Carabeo, Wessam Abdel Hady, Yan Xiong, Kamilia Abdelraouf, Joannellyn Chiu, Dario Lehoux
Publikováno v:
Open Forum Infectious Diseases
Background Exebacase (CF-301) is a novel lysin with rapid bacteriolytic and anti-biofilm activity against S. aureus, pronounced synergy with antibiotics and low propensity for resistance. Exebacase has undergone Phase 1–2 trials. This work was to d
Autor:
Majid Kerolous, Stephan Ortiz, Chun Lin Chen, Harold M. Wright, Parviz Ghahramani, Daksha Desai-Krieger
Publikováno v:
American Journal of Therapeutics
Combining different classes of antihypertensives is more effective for reducing blood pressure (BP) than increasing the dose of monotherapies. The aims of this phase I study were to investigate pharmacokinetic and pharmacodynamic interactions between