Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Parvinder Hothi"'
Autor:
Parvinder Hothi, Charles Cobbs
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
The most active human endogenous retrovirus K (HERV-K) subtype, HML-2, has been implicated as a driver of oncogenesis in several cancers. However, the presence and function of HML-2 in malignant gliomas has remained unclear. In this issue of the JCI,
Externí odkaz:
https://doaj.org/article/3c36c6e497684c7991236152ca1a9c4f
Autor:
Javier I. J. Orozco, Theo A. Knijnenburg, Ayla O. Manughian-Peter, Matthew P. Salomon, Garni Barkhoudarian, John R. Jalas, James S. Wilmott, Parvinder Hothi, Xiaowen Wang, Yuki Takasumi, Michael E. Buckland, John F. Thompson, Georgina V. Long, Charles S. Cobbs, Ilya Shmulevich, Daniel F. Kelly, Richard A. Scolyer, Dave S. B. Hoon, Diego M. Marzese
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The treatment of brain metastases is often limited by the ability to diagnose their origins. Here the authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of meta
Externí odkaz:
https://doaj.org/article/48d7f470aacb41c6b7ae96cfd0196169
Autor:
Che Liu, Kien Pham, Defang Luo, Brent A Reynolds, Parvinder Hothi, Gregory Foltz, Jeffrey K Harrison
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59750 (2013)
Glioblastoma (GBM) is the most common primary brain tumor in adults. The poor prognosis and minimally successful treatments of these tumors indicates a need to identify new therapeutic targets. Therapy resistance of GBMs is attributed to heterogeneit
Externí odkaz:
https://doaj.org/article/c4396c49f3a6498a8a030b3de656c77d
Autor:
Matias A. Bustos, Negin Rahimzadeh, Suyeon Ryu, Rebecca Gross, Linh T. Tran, Victor M. Renteria-Lopez, Romela I. Ramos, Amy Eisenberg, Parvinder Hothi, Santosh Kesari, Garni Barkhoudarian, Yuki Takasumi, Charles Cobbs, Daniel F. Kelly, Dave S.B. Hoon
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 102(7)
Glioblastoma (GBM) is still one of the most commonly diagnosed advanced stage primary brain tumors. Current treatments for patients with primary GBM (pGBM) are often not effective and a significant proportion of the patients with pGBM recur. The effe
Autor:
James S. Wilmott, Ayla O. Manughian-Peter, Diego M. Marzese, Yuki Takasumi, Daniel F. Kelly, Ilya Shmulevich, Matthew P. Salomon, John R. Jalas, Javier I. J. Orozco, Garni Barkhoudarian, Dave S.B. Hoon, Xiaowen Wang, John F. Thompson, Charles Cobbs, Georgina V. Long, Theo A. Knijnenburg, Richard A. Scolyer, Michael E. Buckland, Parvinder Hothi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Optimal treatment of brain metastases is often hindered by limitations in diagnostic capabilities. To meet this challenge, here we profile DNA methylomes of the three most frequent types of brain metastases: melanoma, breast, and lung cancers (n = 96
Autor:
Santosh Kesari, Sui Huang, James H. Park, Adrián López García de Lomana, Nitin S. Baliga, Tiffany Juarez, Diego M. Marzese, Parvinder Hothi, Abdullah H. Feroze, Anoop P. Patel, Charles Cobbs
Publikováno v:
Cancers
Cancers, Vol 13, Iss 3152, p 3152 (2021)
Cancers, Vol 13, Iss 3152, p 3152 (2021)
Simple Summary Pronounced differences across individuals (interpatient variability) and cell–cell heterogeneity within a tumor (intratumoral heterogeneity) severely hinder effective brain tumor treatment. To overcome these challenges, a personalize
Autor:
Diego M. Marzese, James S. Wilmott, Javier I. J. Orozco, Richard A. Scolyer, Charles Cobbs, Matthew P. Salomon, Dave S.B. Hoon, Parvinder Hothi, Ayla O. Manughian-Peter
Publikováno v:
Scientific Data
Brain metastases (BM) are one the most lethal and poorly managed clinical complications in cancer patients. These secondary tumors represent the most common intracranial neoplasm in adults, most frequently originating from lung cancer, breast cancer,
Autor:
Michael Wagenbach, Rick Gussio, Eric Horne, Parvinder Hothi, Philippe Diaz, Brian Haas, Nephi Stella, Benjamin Uhlenbruck, Cong Xu, Ravil R. Petrov, Ernest Hamel, Linda Wordeman
Publikováno v:
European journal of medicinal chemistry. 159
Small molecules that target microtubules (MTs) represent promising therapeutics to treat certain types of cancer, including glioblastoma multiform (GBM). We synthesized modified carbazoles and evaluated their antitumor activity in GBM cells in cultur
Autor:
Kadagidze Zg, Parvinder Hothi, Natalya V. Kaverina, Charles Cobbs, Jae Guen Yoon, Dhimankrishna Ghosh, Brett Schroeder, Nameeta Shah, Anatoly Y. Baryshnikov, Biaoyang Lin, Hwahyang Lee, Ilya V. Ulasov, André Lieber
Publikováno v:
Oncotarget
Oncolytic gene therapy using viral vectors may provide an attractive therapeutic option for malignant gliomas. These viral vectors are designed in a way to selectively target tumor cells and spare healthy cells. To determine the translational impact,
Autor:
Charles Cobbs, Jae Geun Yoon, Haidn Foster, John Butters, Theodore Nicolaides, Michael D. Prados, Tomoko Ozawa, Parvinder Hothi, Mike Butters, Xavier Figueroa, Ilya V. Ulasov
Publikováno v:
Journal of neuro-oncology. 133(2)
Electromagnetic fields (EMF) in the radio frequency energy (RFE) range can affect cells at the molecular level. Here we report a technology that can record the specific RFE signal of a given molecule, in this case the siRNA of epidermal growth factor