Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Parvesh Chaudhry"'
Autor:
Akil A. Merchant, Aparna Jorapur, Amy McManus, Ren Liu, Valery Krasnoperov, Parvesh Chaudhry, Mohan Singh, Lisa Harton, Mary Agajanian, Miriam Kim, Timothy J. Triche, Jr, Brian J. Druker, Jeffrey W. Tyner, Parkash S. Gill
Publikováno v:
Blood Advances, Vol 1, Iss 20, Pp 1635-1644 (2017)
Abstract: EPHB4, an ephrin type B receptor, is implicated in the growth of several epithelial tumors and is a promising target in cancer therapy; however, little is known about its role in hematologic malignancies. In this article, we show that EPHB4
Externí odkaz:
https://doaj.org/article/19768229a4874092be482d8c1013911e
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86987 (2014)
Many patients diagnosed with ovarian cancer experience recurrence and metastasis, two aspects that will often cause their demise. Epithelial-to-mesenchymal transition (EMT) is a key process involved in cancer progression. With increasing evidence lin
Externí odkaz:
https://doaj.org/article/8632fc11bbe048509092920c3ad92a6e
Autor:
Ciaran O'Riain, Jolanta Kupryjanczyk, Karen H. Lu, Bryan T. Hennessy, Ilary Ruscito, John J. O'Leary, Elizabeth M. Swisher, Stephen F. Madden, Gordon B. Mills, Julie M. Cunningham, Jalid Sehouli, Herbert Yu, Dionyssios Katsaros, Sharon O'Toole, Britta K. Stordal, Norman Häfner, Roshni Kalachand, David Thomas, Jessica N. McAlpine, Parvesh Chaudhry, Simon A. Joosse, Kirsten Timms, Ingo B. Runnebaum, Sarah S. Bernards, Mark S. Carey, Atanas Ignatov, Elena Ioana Braicu, Katharina Prieske, David D.L. Bowtell, Benjamin C. Chandler, Ellen L. Goode, Linn Woelber, Agnieszka Podgorska, Iwona K. Rzepecka
Publikováno v:
J Natl Cancer Inst
BackgroundBRCA1 methylation has been associated with homologous recombination deficiency, a biomarker of platinum sensitivity. Studies evaluating BRCA1-methylated tubal and ovarian cancer (OC) do not consistently support improved survival following p
Autor:
Valery Krasnoperov, Lisa Harton, Brian J. Druker, Aparna Jorapur, Parvesh Chaudhry, Parkash S. Gill, Mohan Singh, Jeffrey W. Tyner, Akil Merchant, Ren Liu, Mary Agajanian, Amy R. McManus, Miriam Y. Kim, Timothy J. Triche
Publikováno v:
Blood Advances. 1:1635-1644
EPHB4, an ephrin type B receptor, is implicated in the growth of several epithelial tumors and is a promising target in cancer therapy; however, little is known about its role in hematologic malignancies. In this article, we show that EPHB4 is highly
Publikováno v:
Blood. 129:3465-3475
The Hedgehog (Hh) signaling pathway is activated in many cancers and is a promising target for therapeutic development. Deletions in the receptor Patched (PTCH) or activating mutations in Smoothened (SMO) have been reported in basal cell carcinoma an
Autor:
Parvesh Chaudhry, Michael Jamieson
Publikováno v:
Reference Module in Biomedical Sciences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::431c44fbeb0f54e7825628f0450c25d1
https://doi.org/10.1016/b978-0-12-801238-3.65585-x
https://doi.org/10.1016/b978-0-12-801238-3.65585-x
Publikováno v:
Molecular and Cellular Biochemistry. 368:119-126
Epithelial ovarian cancer (EOC) represents the most challenging of gynecological malignancies. Defective apoptosis is a major causative factor in the development and progression of cancer. The two important pathways of apoptosis are extrinsic death r
Publikováno v:
Molecular and Cellular Biology. 32:826-839
Prostate apoptosis response 4 (Par-4) is a ubiquitously expressed proapoptotic tumor suppressor protein. Here, we show for the first time, that Par-4 is a novel substrate of caspase-3 during apoptosis. We found that Par-4 is cleaved during cisplatin-
Publikováno v:
Molecular Cancer Therapeutics. 11:267-276
Signaling from the human hematopoietic stem cell (HSC) niche formed by osteoblastic cells regulates hematopoiesis. We previously found that retinoic acid receptor alpha (RARα), a transcription factor activated by retinoic acid (RA), mediates both gr