Výsledky vyhledávání - "Parvathi Sinha"

Identification of 4-Anilinoquin(az)oline as a Cell-Active Protein Kinase Novel 3 (PKN3) Inhibitor Chemotype

Autor: Christopher R. M. Asquith, Louisa Temme, Michael P. East, Tuomo Laitinen, Julie Pickett, Frank E. Kwarcinski, Parvathi Sinha, Carrow I. Wells, Gary L. Johnson, Reena Zutshi, David H. Drewry

Publikováno v: ChemMedChem

Deep annotation of a library of 4-anilinoquinolines led to the identification of 7-iodo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine 16 as a potent inhibitor (IC(50) = 14 nM) of Protein Kinase Novel 3 (PKN3) with micromolar activity in cells. Compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726b88b789476418a97cda78a2b22181
https://pubmed.ncbi.nlm.nih.gov/35403825

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A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation

Autor: Apirat Chaikuad, Alfredo Picado, Shubin Liu, Stefan Knapp, Frank E Kwarcinski, Reena Zutshi, Parvathi Sinha, David H. Drewry, Safal Shrestha, Carrow I. Wells, Chandi S de Silva, Julie E. Pickett, William J. Zuercher, Natarajan Kannan, Timothy M. Willson

Publikováno v: Journal of medicinal chemistry 63(23), 14626-14646 (2020). doi:10.1021/acs.jmedchem.0c01174
J Med Chem

Journal of medicinal chemistry 63(23), 14626 - 14646 (2020). doi:10.1021/acs.jmedchem.0c01174
STK17B is a member of the death-associated protein kinase family and has been genetically linked to the development of diverse diseases. However, the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9c848f02a1d2a5cb888f5579bfc7d4
https://bib-pubdb1.desy.de/record/454003

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Cellular Responses to the DNA Damaging Natural Compound Leinamycin

Autor: Daekyu Sun, Yoon Joo Shin, Kent S. Gates, Parvathi Sinha, Allison M. Hays

Publikováno v: Journal of Cancer Science & Therapy.

Leinamycin is a thiol dependent DNA alkylating agent which shows very potent activity against various human cancer cell lines (IC50 values in the low nanomolar range). This natural compound forms guanine adducts (N7) in DNA which are converted into a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65c84e169ba88e4a5d11807fa8bef7d1
https://doi.org/10.4172/1948-5956.s8-003

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