Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Parvathi M. Devarakonda"'
Autor:
John B. Lees-Shepard, Sean J. Stoessel, Julian T. Chandler, Keith Bouchard, Patricia Bento, Lorraine N. Apuzzo, Parvathi M. Devarakonda, Jeffrey W. Hunter, David J. Goldhamer
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive and catastrophic heterotopic ossification (HO) of skeletal muscle and associated soft tissues. FOP is caused by dominantly acting mutations in the gene
Externí odkaz:
https://doaj.org/article/d1d78e06be5a433aa33e6845557009ed
Autor:
Giselle A. Joseph, Margaret Hung, Aviva J. Goel, Mingi Hong, Marysia-Kolbe Rieder, Noam D. Beckmann, Madhavika N. Serasinghe, Jerry E. Chipuk, Parvathi M. Devarakonda, David J. Goldhamer, Paulina Aldana-Hernandez, Jonathan Curtis, René L. Jacobs, Robert S. Krauss
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-17 (2019)
Abstract Background Group I Paks are serine/threonine kinases that function as major effectors of the small GTPases Rac1 and Cdc42, and they regulate cytoskeletal dynamics, cell polarity, and transcription. We previously demonstrated that Pak1 and Pa
Externí odkaz:
https://doaj.org/article/31317f8c00e84f5db79bb5fc800436e5
Autor:
John B. Lees-Shepard, Masakazu Yamamoto, Arpita A. Biswas, Sean J. Stoessel, Sarah-Anne E. Nicholas, Cathy A. Cogswell, Parvathi M. Devarakonda, Michael J. Schneider, Samantha M. Cummins, Nicholas P. Legendre, Shoko Yamamoto, Vesa Kaartinen, Jeffrey W. Hunter, David J. Goldhamer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Fibrodysplasia ossificans progressiva is a severe disorder characterized by heterotopic ossification, and is caused by mutations in ACVR1. Here, the authors show that expression of mutant ACVR1 in fibro/adipogenic progenitors recapitulates disease pr
Externí odkaz:
https://doaj.org/article/cce620ded4304ad1a71c991a24918aac
Autor:
John B Lees-Shepard, Sarah-Anne E Nicholas, Sean J Stoessel, Parvathi M Devarakonda, Michael J Schneider, Masakazu Yamamoto, David J Goldhamer
Publikováno v:
eLife, Vol 7 (2018)
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by debilitating heterotopic ossification (HO). The retinoic acid receptor gamma agonist, palovarotene, and antibody-mediated activin A blockade have entered human cl
Externí odkaz:
https://doaj.org/article/a67397fb4bc442cf9f3548431a220bd8
Autor:
Sean J. Stoessel, John B Lees-Shepard, Patricia Bento, Keith Bouchard, Jeffrey W. Hunter, David J. Goldhamer, Lorraine N. Apuzzo, Julian Chandler, Parvathi M. Devarakonda
Publikováno v:
Journal of Clinical Investigation. 132
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive and catastrophic heterotopic ossification (HO) of skeletal muscle and associated soft tissues. FOP is caused by dominantly acting mutations in the bone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a067cac4b9446765fde51fe426766b
https://doi.org/10.1172/jci153795
https://doi.org/10.1172/jci153795
Autor:
Jacob A. Kellermeier, Parvathi M. Devarakonda, Porfirio Schiano Lomoriello, Aoife T. Heaslip, Romain Carmeille
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 2, p e1008787 (2021)
PLoS Pathogens, Vol 17, Iss 2, p e1008787 (2021)
Toxoplasma gondii is an obligate intracellular parasite that relies on three distinct secretory organelles, the micronemes, rhoptries, and dense granules, for parasite survival and disease pathogenesis. Secretory proteins destined for these organelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd10adb707f0b812a7941fc7c54a7c7
https://doi.org/10.1371/journal.ppat.1008787
https://doi.org/10.1371/journal.ppat.1008787
Autor:
Parvathi M. Devarakonda, Sarah-Anne E. Nicholas, Sean J. Stoessel, John B Lees-Shepard, Masakazu Yamamoto, Michael J Schneider, David J. Goldhamer
Publikováno v:
eLife, Vol 7 (2018)
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by debilitating heterotopic ossification (HO). The retinoic acid receptor gamma agonist, palovarotene, and antibody-mediated activin A blockade have entered human cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b09e074a37833a54fd47482dd8cc1c
https://doi.org/10.7554/elife.40814
https://doi.org/10.7554/elife.40814
Autor:
Sarah-Anne E. Nicholas, Sean J. Stoessel, John B Lees-Shepard, Masakazu Yamamoto, David J. Goldhamer, Parvathi M. Devarakonda, Michael J Schneider
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7cae85f06fd1efe08f4d57304fed9c7
https://doi.org/10.7554/elife.40814.021
https://doi.org/10.7554/elife.40814.021
Autor:
Jeffrey W. Hunter, Nicholas P. Legendre, David J. Goldhamer, Sarah Anne E. Nicholas, Masakazu Yamamoto, Michael J Schneider, Arpita A. Biswas, Samantha M. Cummins, Sean J. Stoessel, John B Lees-Shepard, Shoko Yamamoto, Cathy A. Cogswell, Vesa Kaartinen, Parvathi M. Devarakonda
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disorder characterized by progressive and profoundly disabling heterotopic ossification (HO). Here we show that fibro/adipogenic progenitors (FAPs) are a major cell-of-origin of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7492bcdb795aaa02d1efcd6ee5a91e12
http://europepmc.org/articles/PMC5797136
http://europepmc.org/articles/PMC5797136
Autor:
Romain Carmeille, Porfirio Schiano Lomoriello, Parvathi M Devarakonda, Jacob A Kellermeier, Aoife T Heaslip
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1008787 (2021)
Toxoplasma gondii is an obligate intracellular parasite that relies on three distinct secretory organelles, the micronemes, rhoptries, and dense granules, for parasite survival and disease pathogenesis. Secretory proteins destined for these organelle
Externí odkaz:
https://doaj.org/article/147a7c74a65a4516aba549137fecf26f