Developmental oxidative stress leads to T-type Ca2+ channel hypofunction in thalamic reticular nucleus of mouse models pertinent to schizophrenia

Autor: Corinne El Khoueiry, Jan-Harry Cabungcal, Zita Rovó, Margot Fournier, Kim Q. Do, Pascal Steullet

Publikováno v: Molecular psychiatry, vol. 27, no. 4, pp. 2042-2051

Impairment of parvalbumin interneurons induced by oxidative stress (OxS) is a “hub” on which converge several genetic and environmental risk factors associated with schizophrenia. In patients, this could be a mechanism leading to anomalies of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29191fafe57b3339cf92a232d16ffa9
https://doi.org/10.1038/s41380-021-01425-2

Caught in vicious circles: a perspective on dynamic feed-forward loops driving oxidative stress in schizophrenia

Autor: Cuenod, M., Steullet, P., Cabungcal, J.H., Dwir, D., Khadimallah, I., Klauser, P., Conus, P., Do, K.Q.

Publikováno v: Molecular psychiatry, vol. 27, no. 4, pp. 1886-1897

A growing body of evidence has emerged demonstrating a pathological link between oxidative stress and schizophrenia. This evidence identifies oxidative stress as a convergence point or "central hub" for schizophrenia genetic and environmental risk fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1900::83cc1a1a7eaeca660d6aa8af8f629015
https://serval.unil.ch/notice/serval:BIB_49CB12C0C114

A lack of GluN2A-containing NMDA receptors confers a vulnerability to redox dysregulation: Consequences on parvalbumin interneurons, and their perineuronal nets

Autor: Daniella Dwir, Pascal Steullet, Romain Cardis, Kim Q. Do, Jan-Harry Cabungcal

Publikováno v: Neurobiology of disease, vol. 109, no. Pt A, pp. 64-75
Neurobiology of Disease, Vol 109, Iss, Pp 64-75 (2018)

The GluN2A subunit of NMDA receptors (NMDARs) plays a critical role during postnatal brain development as its expression increases while Glun2B expression decreases. Mutations and polymorphisms in GRIN2A gene, coding for GluN2A, are linked to develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107ea94cae8ebf7363d9a8bcbe1d5971
https://doi.org/10.1016/j.nbd.2017.10.006

Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A 'central hub' in schizophrenia pathophysiology?

Autor: Michel Cuenod, Kim Q. Do, Jan-Harry Cabungcal, Daniella Dwir, Pascal Steullet, Patricio O'Donnell, Aline Monin

Publikováno v: Schizophrenia research, vol. 176, no. 1, pp. 41-51

Accumulating evidence points to altered GABAergic parvalbumin-expressing interneurons and impaired myelin/axonal integrity in schizophrenia. Both findings could be due to abnormal neurodevelopmental trajectories, affecting local neuronal networks and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adfb9f438b68070d8600fe2171d9a6a
https://doi.org/10.1016/j.schres.2014.06.021

Cell-type-specific recruitment of amygdala interneurons to hippocampal theta rhythm and noxious stimuli in vivo

Autor: Francesco Ferraguti, Thomas C.M. Bienvenu, Marco Capogna, Daniela Busti, Peter J. Magill

Publikováno v: Bienvenu, T C M, Busti, D, Magill, P J, Ferraguti, F & Capogna, M 2012, ' Cell-type-specific recruitment of amygdala interneurons to hippocampal theta rhythm and noxious stimuli in vivo ', Neuron, vol. 74, no. 6, pp. 1059-74 . https://doi.org/10.1016/j.neuron.2012.04.022
Neuron

Summary Neuronal synchrony in the basolateral amygdala (BLA) is critical for emotional behavior. Coordinated theta-frequency oscillations between the BLA and the hippocampus and precisely timed integration of salient sensory stimuli in the BLA are in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2d2741245e3db60afc7b137d226149
https://doi.org/10.1016/j.neuron.2012.04.022