Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Parul S. Pall"'
Autor:
Jeanine E. Ballard, Parul S. Pall, Joshua Vardigan, Fuqiang Zhao, Marie A. Holahan, Xiaoping Zhou, Nina Jochnowitz, Richard L. Kraus, Rebecca M. Klein, Darrell A. Henze, Andrea K. Houghton, Christopher S. Burgey, Christopher Gibson, Arie Struyk
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
MK-2075 is a small-molecule selective inhibitor of the NaV1.7 channel investigated for the treatment of postoperative pain. A translational strategy was developed for MK-2075 to quantitatively interrelate drug exposure, target modulation, and the des
Externí odkaz:
https://doaj.org/article/b6acf3025c844a49ac376ac7097521ef
Autor:
Gregory L. Adams, Parul S. Pall, Steven M. Grauer, Xiaoping Zhou, Jeanine E. Ballard, Marissa Vavrek, Richard L. Kraus, Pierre Morissette, Nianyu Li, Stefania Colarusso, Elisabetta Bianchi, Anandan Palani, Rebecca Klein, Christopher T. John, Deping Wang, Matthew Tudor, Andrew F. Nolting, Mirlinda Biba, Timothy Nowak, Alexey A. Makarov, Mikhail Reibarkh, Alexei V. Buevich, Wendy Zhong, Erik L. Regalado, Xiao Wang, Qi Gao, Aurash Shahripour, Yuping Zhu, Daniele de Simone, Tommaso Frattarelli, Nicolo’ Maria Pasquini, Paola Magotti, Roberto Iaccarino, Yuxing Li, Kelli Solly, Keun-Joong Lee, Weixun Wang, Feifei Chen, Haoyu Zeng, Jixin Wang, Hilary Regan, Rupesh P. Amin, Christopher P. Regan, Christopher S. Burgey, Darrell A. Henze, Chengzao Sun, David M. Tellers
Publikováno v:
Journal of Medicinal Chemistry. 65:485-496
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ecd04283fe1d38ba43c9ca77818a20e
https://doi.org/10.1021/acs.jmedchem.1c01570
https://doi.org/10.1021/acs.jmedchem.1c01570
Autor:
Richard L. Kraus, Ronald M. Kim, Jeanine E. Ballard, Thomas J. Greshock, Andrea K. Houghton, Michelle K. Clements, Marie A. Holahan, Andrew Danziger, Christopher S. Burgey, Yuxing Li, Mark E. Layton, Jordi Serra, Parul S. Pall, Rebecca M. Klein, Joshua D. Vardigan, Dan Zhou, Fuqiang Zhao, Christopher Daley, Darrell A. Henze
Publikováno v:
Science Translational Medicine. 13
Humans with loss-of-function mutations in the Nav1.7 channel gene (SCN9A) show profound insensitivity to pain, whereas those with gain-of-function mutations can have inherited pain syndromes. Therefore, inhibition of the Nav1.7 channel with a small m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2568b727c558da3b3a2a03b719a658df
https://doi.org/10.1126/scitranslmed.aay1050
https://doi.org/10.1126/scitranslmed.aay1050
Autor:
Joshua D. Vardigan, Christopher R. Gibson, Darrell A. Henze, Andrea K. Houghton, Marie A. Holahan, Fuqiang Zhao, Parul S. Pall, Richard L. Kraus, Yuxing Li, Jeanine E. Ballard, Christopher S. Burgey
Publikováno v:
Pharmaceutical Research
Purpose This work describes a staged approach to the application of pharmacokinetic-pharmacodynamic (PK-PD) modeling in the voltage-gated sodium ion channel (NaV1.7) inhibitor drug discovery effort to address strategic questions regarding in vitro to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d130ec34ee918806de2014440a8f808
http://europepmc.org/articles/PMC7473964
http://europepmc.org/articles/PMC7473964
Publikováno v:
Neuroscience Letters. 655:82-89
The facet joint is a common source of neck pain, particularly after excessive stretch of its capsular ligament. Peptidergic afferents have been shown to have an important role in the development and maintenance of mechanical hyperalgesia, dysregulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ca9245212313ae9cb9eee3af595f25
https://doi.org/10.1016/j.neulet.2017.07.006
https://doi.org/10.1016/j.neulet.2017.07.006
Autor:
Richard L, Kraus, Fuqiang, Zhao, Parul S, Pall, Dan, Zhou, Joshua D, Vardigan, Andrew, Danziger, Yuxing, Li, Christopher, Daley, Jeanine E, Ballard, Michelle K, Clements, Rebecca M, Klein, Marie A, Holahan, Thomas J, Greshock, Ronald M, Kim, Mark E, Layton, Christopher S, Burgey, Jordi, Serra, Darrell A, Henze, Andrea K, Houghton
Publikováno v:
Science translational medicine. 13(594)
Humans with loss-of-function mutations in the Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9833016998efa2956e0258637677db9
https://pubmed.ncbi.nlm.nih.gov/34011626
https://pubmed.ncbi.nlm.nih.gov/34011626
Autor:
Joshua D. Vardigan, Jeanine E. Ballard, Parul S Pall, Emily D Adarayan, Jason M. Uslaner, Darrell A. Henze, Henry S Lange, Andrea K. Houghton
Publikováno v:
Journal of Pain Research
Joshua D Vardigan,Andrea K Houghton,Henry S Lange,Emily D Adarayan,Parul S Pall, Jeanine E Ballard, Darrell A Henze,Jason M Uslaner Merck Research Laboratories, West Point, PA, USA Introduction: The development of novel analgesics to treat acute or c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2213183a116da3df08dcf7bd1cccec4a
https://www.dovepress.com/pharmacological-validation-of-a-novel-nonhuman-primate-measure-of-ther-peer-reviewed-article-JPR
https://www.dovepress.com/pharmacological-validation-of-a-novel-nonhuman-primate-measure-of-ther-peer-reviewed-article-JPR
Publikováno v:
Neuroscience Letters. 604:193-198
Non-physiological stretch of the cervical facet joint's capsular ligament induces persistent behavioral hypersensitivity and spinal neuronal hyperexcitability via an intra-articular NGF-dependent mechanism. Although that ligament is innervated by noc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e736c866ecf17e9306ce8770e3007932
https://doi.org/10.1016/j.neulet.2015.07.043
https://doi.org/10.1016/j.neulet.2015.07.043
Publikováno v:
The Journal of Pain. 16:741-749
Allergic contact dermatitis (ACD) is a common condition that can significantly affect the quality of life. Contact with allergens results in delayed hypersensitivity reactions involving T lymphocytes, with associated skin inflammation and spontaneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4cef8cccd7a4e04fd8aabcc3564596
https://doi.org/10.1016/j.jpain.2015.04.009
https://doi.org/10.1016/j.jpain.2015.04.009