Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode.

Autor: Moyano PM; Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, Brno, 625 00, Czech Republic.; International Clinical Research Centre, St. Anne's University Hospital, Pekařská 53, Brno, 656 91, Czech Republic., Kubina T; Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, Brno, 625 00, Czech Republic., Paruch ŠO; Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, Brno, 625 00, Czech Republic., Jarošková A; Institute of Biophysics, Czech Academy of Science, Královopolská 135, 612 00, Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, Brno, 625 00, Czech Republic., Novotný J; Institute of Biophysics, Czech Academy of Science, Královopolská 135, 612 00, Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, Brno, 625 00, Czech Republic., Skočková V; Institute of Biophysics, Czech Academy of Science, Královopolská 135, 612 00, Brno, Czech Republic., Ovesná P; Institute of Biostatistics and Analyses, Masaryk University, Kamenice 5, Brno, 625 00, Czech Republic., Suchánková T; Institute of Biophysics, Czech Academy of Science, Královopolská 135, 612 00, Brno, Czech Republic., Prokofeva P; Proteomics and Bioanalytics, Department of Molecular Life Sciences, School of Life Sciences, Technical University of Munich, Freising, 85354, Germany., Kuster B; Proteomics and Bioanalytics, Department of Molecular Life Sciences, School of Life Sciences, Technical University of Munich, Freising, 85354, Germany., Šmída M; CEITEC, Masaryk University, Kamenice 5, Brno, 625 00, Czech Republic., Chaikuad A; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 15, Frankfurt am Main, 60438, Germany., Krämer A; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 15, Frankfurt am Main, 60438, Germany., Knapp S; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 15, Frankfurt am Main, 60438, Germany., Souček K; International Clinical Research Centre, St. Anne's University Hospital, Pekařská 53, Brno, 656 91, Czech Republic.; Institute of Biophysics, Czech Academy of Science, Královopolská 135, 612 00, Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, Brno, 625 00, Czech Republic., Paruch K; Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 5, Brno, 625 00, Czech Republic.; International Clinical Research Centre, St. Anne's University Hospital, Pekařská 53, Brno, 656 91, Czech Republic.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Nov 06, pp. e202412786. Date of Electronic Publication: 2024 Nov 06.

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.

Autor: Němec V; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany.; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Remeš M; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Beňovský P; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Böck MC; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Šranková E; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Wong JF; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Cros J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Williams E; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Tse LH; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Smil D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Ensan D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Isaac MB; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Gomolková R; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic., Ursachi VC; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Fafílek B; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Kahounová Z; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Víchová R; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Vacek O; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Berger BT; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany., Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Corona CR; Promega Corporation, Madison, Wisconsin 53716, United States., Vasta JD; Promega Corporation, Madison, Wisconsin 53716, United States., Robers MB; Promega Corporation, Madison, Wisconsin 53716, United States., Krejci P; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Souček K; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Bullock AN; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Knapp S; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany., Paruch K; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Aug 08; Vol. 67 (15), pp. 12632-12659. Date of Electronic Publication: 2024 Jul 18.

CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1.

Autor: Hluchý M; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Gajdušková P; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Ruiz de Los Mozos I; The Francis Crick Institute, London, UK.; Department of Personalized Medicine, NASERTIC, Government of Navarra, Pamplona, Spain.; Center for Applied Medical Research, University of Navarra, Pamplona, Spain., Rájecký M; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Kluge M; Institut für Informatik, Ludwig-Maximilians-Universität München, München, Germany., Berger BT; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences (BMLS), Goethe University Frankfurt am Main, Frankfurt am Main, Germany.; Institut für Pharmazeutische Chemie, Goethe University Frankfurt am Main, Frankfurt am Main, Germany., Slabá Z; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Potěšil D; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Weiß E; Institut für Informatik, Ludwig-Maximilians-Universität München, München, Germany., Ule J; The Francis Crick Institute, London, UK.; UK Dementia Research Institute, King's College London, London, UK., Zdráhal Z; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic., Knapp S; Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences (BMLS), Goethe University Frankfurt am Main, Frankfurt am Main, Germany.; Institut für Pharmazeutische Chemie, Goethe University Frankfurt am Main, Frankfurt am Main, Germany., Paruch K; Department of Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.; International Clinical Research Center, St Anne's University Hospital in Brno, Brno, Czech Republic., Friedel CC; Institut für Informatik, Ludwig-Maximilians-Universität München, München, Germany., Blazek D; Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic. dalibor.blazek@ceitec.muni.cz.

Publikováno v: Nature [Nature] 2022 Sep; Vol. 609 (7928), pp. 829-834. Date of Electronic Publication: 2022 Sep 14.

Author Correction: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.

Autor: Kameda-Smith MM; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Zhu H; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; University Health Network, Toronto, ON, Canada.; Vector Institute Toronto, Toronto, ON, Canada., Luo EC; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Suk Y; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada., Xella A; Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Yee B; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Chokshi C; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Xing S; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Tan F; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Fox RG; Departments of Pharmacology and Medicine, University of California San Diego School of Medicine, Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Adile AA; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Bakhshinyan D; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Brown K; Donnelly Centre, Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Gwynne WD; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Subapanditha M; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Miletic P; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Picard D; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany., Burns I; Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada., Moffat J; Donnelly Centre, Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Paruch K; Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital in Brno, 602 00, Brno, Czech Republic., Fleming A; Departments of Pediatrics, Hematology and Oncology Division, McMaster University, Hamilton, ON, Canada., Hope K; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Provias JP; Department of Neuropathology, McMaster University, Hamilton, ON, Canada., Remke M; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany., Lu Y; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Reya T; Departments of Pharmacology and Medicine, University of California San Diego School of Medicine, Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.; Herbert Irving Comprehensive Cancer Center, Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY, USA., Venugopal C; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Reimand J; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. rjw2169@cumc.columbia.edu.; Herbert Irving Comprehensive Cancer Center, Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY, USA. rjw2169@cumc.columbia.edu., Yeo GW; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA. geneyeo@ucsd.edu.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA. geneyeo@ucsd.edu.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA. geneyeo@ucsd.edu., Singh SK; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada. ssingh@mcmaster.ca.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada. ssingh@mcmaster.ca.; Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. ssingh@mcmaster.ca.; Department of Pediatrics, McMaster University, Hamilton, ON, Canada. ssingh@mcmaster.ca.

Publikováno v: Nature communications [Nat Commun] 2023 Jan 10; Vol. 14 (1), pp. 136. Date of Electronic Publication: 2023 Jan 10.

Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma.

Autor: Kameda-Smith MM; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Zhu H; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Canada.; University Health Network, Toronto, ON, Canada.; Vector Institute Toronto, Toronto, ON, Canada., Luo EC; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Suk Y; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Michael G DeGroote School of Medicine, McMaster University, Hamilton, Canada., Xella A; Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Yee B; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Chokshi C; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Xing S; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Tan F; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Fox RG; Departments of Pharmacology and Medicine, University of California San Diego School of Medicine, Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA., Adile AA; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Bakhshinyan D; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Brown K; Donnelly Centre, Department of Molecular Genetics, University of Toronto, Toronto, Canada., Gwynne WD; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Subapanditha M; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada., Miletic P; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Picard D; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany., Burns I; Michael G DeGroote School of Medicine, McMaster University, Hamilton, Canada., Moffat J; Donnelly Centre, Department of Molecular Genetics, University of Toronto, Toronto, Canada., Paruch K; Department of Chemistry, CZ Openscreen, Faculty of Science, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital in Brno, 602 00, Brno, Czech Republic., Fleming A; McMaster University, Departments of Pediatrics, Hematology and Oncology Division, Hamilton, Canada., Hope K; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Provias JP; McMaster University, Departments of Neuropathology, Hamilton, Canada., Remke M; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany., Lu Y; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Reya T; Departments of Pharmacology and Medicine, University of California San Diego School of Medicine, Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.; Herbert Irving Comprehensive Cancer Center, Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY, USA., Venugopal C; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada.; Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Reimand J; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, National Cancer Institute-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. rjw2169@cumc.columbia.edu.; Herbert Irving Comprehensive Cancer Center, Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY, USA. rjw2169@cumc.columbia.edu., Yeo GW; Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA, USA. geneyeo@ucsd.edu.; Stem Cell Program, University of California San Diego, La Jolla, CA, USA. geneyeo@ucsd.edu.; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA. geneyeo@ucsd.edu., Singh SK; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, ON, Canada. ssingh@mcmaster.ca.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada. ssingh@mcmaster.ca.; Surgery, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada. ssingh@mcmaster.ca.; McMaster University, Department of Pediatrics, Hamilton, Canada. ssingh@mcmaster.ca.

Publikováno v: Nature communications [Nat Commun] 2022 Dec 06; Vol. 13 (1), pp. 7506. Date of Electronic Publication: 2022 Dec 06.