Výsledky vyhledávání - "Partners in Prevention Hsv"

Akademický článek

Whole genome sequencing of extreme phenotypes identifies variants in CD101 and UBE2V1 associated with increased risk of sexually acquired HIV-1.

Autor: Romel D Mackelprang, Michael J Bamshad, Jessica X Chong, Xuanlin Hou, Kati J Buckingham, Kathryn Shively, Guy deBruyn, Nelly R Mugo, James I Mullins, M Juliana McElrath, Jared M Baeten, Connie Celum, Mary J Emond, Jairam R Lingappa, Partners in Prevention HSV/HIV Transmission Study and the Partners PrEP Study Teams

Publikováno v: PLoS Pathogens, Vol 13, Iss 11, p e1006703 (2017)

Host genetic variation modifying HIV-1 acquisition risk can inform development of HIV-1 prevention strategies. However, associations between rare or intermediate-frequency variants and HIV-1 acquisition are not well studied. We tested for the associa

Externí odkaz: https://doaj.org/article/9cf3ce40b8ed44d4a49ffeaf7035ff55

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Akademický článek

Using plasma viral load to guide antiretroviral therapy initiation to prevent HIV-1 transmission.

Autor: Pamela M Murnane, James P Hughes, Connie Celum, Jairam R Lingappa, Nelly Mugo, Carey Farquhar, James Kiarie, Anna Wald, Jared M Baeten, Partners in Prevention HSV/HIV Transmission Study Team

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e51192 (2012)

Current WHO guidelines recommend antiretroviral therapy (ART) initiation at CD4 counts ≤350 cells/µL. Increasing this threshold has been proposed, with a primary goal of reducing HIV-1 infectiousness. Because the quantity of HIV-1 in plasma is the

Externí odkaz: https://doaj.org/article/e9fa8a3afca0490aad19d40083ca8bec

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Akademický článek

Viral linkage in HIV-1 seroconverters and their partners in an HIV-1 prevention clinical trial.

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e16986 (2011)

BACKGROUND:Characterization of viruses in HIV-1 transmission pairs will help identify biological determinants of infectiousness and evaluate candidate interventions to reduce transmission. Although HIV-1 sequencing is frequently used to substantiate

Externí odkaz: https://doaj.org/article/1e270772cdb84391b463534e8bb0333b

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Akademický článek

Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.

Publikováno v: PLoS ONE, Vol 6, Iss 12, p e28632 (2011)

Host genetic factors may be important determinants of HIV-1 sexual acquisition. We performed a genome-wide association study (GWAS) for host genetic variants modifying HIV-1 acquisition and viral control in the context of a cohort of African HIV-1 se

Externí odkaz: https://doaj.org/article/b3aa5aba42484a37b1e05a560b85064c

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Akademický článek

Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk.

Autor: Jairam R Lingappa, James P Hughes, Richard S Wang, Jared M Baeten, Connie Celum, Glenda E Gray, Wendy S Stevens, Deborah Donnell, Mary S Campbell, Carey Farquhar, M Essex, James I Mullins, Robert W Coombs, Helen Rees, Lawrence Corey, Anna Wald, Partners in Prevention HSV/HIV Transmission Study Team

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12598 (2010)

The risk of sexual transmission of HIV-1 is strongly associated with the level of HIV-1 RNA in plasma making reduction in HIV-1 plasma levels an important target for HIV-1 prevention interventions. A quantitative understanding of the relationship of

Externí odkaz: https://doaj.org/article/573404ca39bc4dafb8269454b860aadf

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